Frequency of Family History of Acute Myocardial Infarction in Patients With Acute Myocardial Infarction

Can family history be used as a tool for public health and preventive medicine?

“…Henderson and Scheuner report on a study of managed care members where 53 charts from 15 primary care physicians selected randomly were reviewed for family history. 12 This included data Table 1 Prevalence and relative risk estimates due to family history for selected diseases Disease U.S. prevalence of the disease Risk due to family history Cardiovascular disease 58 million OR ϭ 2.0 (one 1st-degree relative) 38 OR ϭ 5.4 (two or more 1st-degree relatives with onset Ͻ55 yr) 39 Breast cancer 3 million women RR ϭ 2.1 (one 1st-degree relative) 40 RR ϭ 3.9 (three or more 1st-degree relatives) 41 Colorectal cancer Yearly incidence ϭ 130,000 OR ϭ 1.7 (one 1st-degree relative) 26 OR ϭ 4.9 (two 1st-degree relatives) 27 Prostate cancer Yearly incidence ϭ 200,000 RR ϭ 3.2 (one 1st-degree relative) 42 RR ϭ 11.0 (three 1st-degree relatives) 43 Melanoma 200,000 OR ϭ 2.7 (one or more 1st-degree relative) 44 OR ϭ 4.3 (one 1st-degree relative) 45 Type II diabetes 13 million RR ϭ 2.4 (mother) 46 RR ϭ 4.0 (maternal and paternal relatives) 47 Osteoporosis 8 million women OR ϭ 2.0 for osteoporotic fracture (female 1st-degree relative) 48 2 million men RR ϭ 2.4 for wrist fracture (father) 49 Asthma 17 million OR ϭ 3.0 (mother) 50 RR ϭ 7.0 (mother and father) 51 Family history tool for public health…”

Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations

“…CAD is based on the coronary atherosclerosis and often manifests with sudden chest pain due to reversible (angina pectoris, AP) or irreversible (myocardial infarction, MI) ischemia in the heart caused by decreased blood flow in coronary arteries. Although environmental factors, such as smoking, hypertension, hypercholesterolemia and diabetes mellitus (DM) significantly contribute to the development of CAD, 1 considerable evidence indicates the involvement of genetic factors in the pathogenesis of CAD 2 and several genome-wide association studies have recently identified susceptibility genes and loci for CAD. [3][4][5] However, not all of the reported associations could be replicated in other studies even if middle to large size samples were investigated in the original report, 6 indicating that the contribution of reported genetic factors was not large enough to be replicated in the other studies.…”

Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease

“…Although environmental or life-style factors, such as smoking, hypertension, hypercholesterolemia and diabetes mellitus, contribute to the development of CAD, 2 genetic factors are also involved in the pathogenesis of CAD. 3 Several large-scale association studies using a large number of genetic variations, including single nucleotide polymorphisms (SNPs), have recently identified the susceptibility genes and loci for CAD. [4][5][6][7][8][9][10][11][12] However, not all of the reported associations could be replicated in other studies even if middle-to large-sized samples were investigated in the original reports, suggesting that the contribution of genetic factors was not large enough to be replicated in some cases.…”