Frequency of Factor V (1691 G → A) Mutation in Turkish Population

Abstract

Frequency of Foclor V (1691 G-A) Mutotion in Turkish Populotion Dear Sir, A mutation in the Factor V gene (1691G-+ A in exon 10) was identified that formed the molecular explanation for the phenotype of APC-resistance in the large majority of affected individuals (1). This mutation, which is associated with a significant increase in tluombotic risk, has been found in 30-5070 of selected families with thrombophilia and in 20Vo of consecutive patients with venous tluombosis (2,3).The prevalence of the FV: Q506 allele is between2To and l07o in Western societies but it varies widely depending on the geographic location and the ethnic background of the population. However, the mutated allele is not found in certain populations, such as the Japanese, Chinese, Africans and native Americans (a-6).

Factor V Leiden and PT G20210A mutations in cancer patients with and without venous thrombosis

“…This difference might be explained by the high prevalence of FVL in the Turkish population is higher than in the Western population (9.8% in Turkish Anatolian) [8].The high frequency of FVL in our cancer patients with TE was associated with its high prevalence among the normal Turkish population. Based upon our results, screening for FVL should be considered in cancer patients with an increased prevalence of TE.…”

A Case of Deep Vein Thrombosis in the Postpartum Period

“…Autosomal dominant factor V Leiden mutation is observed in 7% of the European population, whereas in 4.5-7.1% of the Turkish population (10,11). However, in another study, the prevalence of factor V Leiden mutation in Turkey was reported as 10% (12). Factor V Leiden was detected in 11-29% of patients with VTE.…”

Factor V Leiden mutation as a predisposing factor for veno-occlusive disease following BMT

“…Protein C, protein S, ATIII, and factor VIII levels were in the normal range. Our previous population study 3 had revealed that factor V Leiden heterozygosity was 9.8% with an allelic frequency of 4.9 which is one of the highest in the Western population. Prothrombin gene 20210 G-A heterozygosity was also found to be 2.7% in the Turkish population.…”

“…Genetic analyses were performed as previously described. 3,4 In this ongoing prospective study, 10 consecutive children who received allogeneic BMT were included. The underlying diseases were as follows: AML (n = 5), juvenile myelomonocytic leukemia (n = 1), ␤-thalassemia major (n = 2), SAA (n = 1), Fanconi's anemia (FA; n = 1).…”

“…2 Most cases have been reported in allogeneic HSCT recipients, with only anecdotal reports after autologous transplantation. 1 The seroprevalence for Toxoplasma gondii varies greatly between countries, ranging from less than 15% in some North American studies 3 and in pediatric wards, to 50-80% of adult HSCT recipients in countries with high endemicity such as France. 4 Probably one of the main reasons for the great variability in the frequency of diagnosed cases of toxoplasmosis after HSCT is this varying seroprevalence; the frequency has been estimated to average 0.8%, 5 with Ͻ0.4% in areas of low endemicity to 2-3% in those with high antibody prevalence.…”