2002
DOI: 10.1001/archderm.138.11.1494
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Frequency of Facial Basal Cell Carcinoma Does Not Correlate With Site-Specific UV Exposure

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Cited by 83 publications
(69 citation statements)
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“…Thus, BCC incidence is increasing with an estimated one if three lifetime risk for Caucasian Americans born in the 1990s. While exposure to UVR is recognised as the key causative factor, the relationship is complex; for example, the frequency of lesions on the face does not correlate with site-specific exposure (Heckmann et al, 2002). Prostate cancer appears to result equally from genetic and environmental factors (Lichtenstein et al, 2000).…”
Section: Discussionmentioning
confidence: 99%
“…Thus, BCC incidence is increasing with an estimated one if three lifetime risk for Caucasian Americans born in the 1990s. While exposure to UVR is recognised as the key causative factor, the relationship is complex; for example, the frequency of lesions on the face does not correlate with site-specific exposure (Heckmann et al, 2002). Prostate cancer appears to result equally from genetic and environmental factors (Lichtenstein et al, 2000).…”
Section: Discussionmentioning
confidence: 99%
“…Current evidence points toward an association of these yeasts with basal cell carcinoma (115), the malignant tumor with the highest incidence in Caucasians worldwide. Presently, solar UV light is regarded as the most significant carcinogen for this tumor; however, not all basal cell carcinomas are caused by UV light, as these tumors are rare in certain anatomical areas subjected to intense UV radiation exposure throughout life (i.e., dorsal aspects of the hands) and commonly appear on relatively sun-protected skin localizations (i.e., eyelid, inner canthus, and retroauricular area) (145). In the pathogenesis of basal cell carcinomas, activating mutations of the hedgehog pathway at the cellular level are implicated (94,154), while at the tissue level, they act together with the induction of immune tolerance by the establishing tumor (immunosubversion) (172,178,352).…”
Section: Malassezia-produced Ahr Ligands and Significance Of Ahr Actimentioning
confidence: 99%
“…16 While their degree of importance as an SCC precursor is debated, actinic keratoses (AKs) occur at an earlier age and are the lesion underlying at least some SCCs; the time between developing baldness and developing scalp AKs in the UK averages 35 years. 17 However, for BCC, the position of BCC on the face does not correlate with the site-specific UVR exposure, 18 and migration studies and sun exposure questionnaire studies suggest that childhood sunburn and recreational UVR exposure in the 0-19 years age group appear to be critical for later BCC risk. 19,20 Thus prevention needs to be employed for several decades to have a significant impact.…”
Section: Biological Issuesmentioning
confidence: 99%