Frequency of Facial Basal Cell Carcinoma Does Not Correlate With Site-Specific UV Exposure

Heckmann, Marc; Zogelmeier, Frank; Konz, Birger

doi:10.1001/archderm.138.11.1494

Cited by 83 publications

(69 citation statements)

References 25 publications

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“…Thus, BCC incidence is increasing with an estimated one if three lifetime risk for Caucasian Americans born in the 1990s. While exposure to UVR is recognised as the key causative factor, the relationship is complex; for example, the frequency of lesions on the face does not correlate with site-specific exposure (Heckmann et al, 2002). Prostate cancer appears to result equally from genetic and environmental factors (Lichtenstein et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

A comparison of sunlight exposure in men with prostate cancer and basal cell carcinoma

et al. 2007

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Ultraviolet radiation exposure increases basal cell carcinoma (BCC) risk, but may be protective against prostate cancer. We attempted to identify exposure patterns that confer reduced prostate cancer risk without increasing that of BCC. We used a questionnaire to assess exposure in 528 prostate cancer patients and 442 men with basal cell carcinoma, using 365 benign prostatic hypertrophy patients as controls.

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Section: Discussionmentioning

confidence: 99%

A comparison of sunlight exposure in men with prostate cancer and basal cell carcinoma

et al. 2007

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“…Current evidence points toward an association of these yeasts with basal cell carcinoma (115), the malignant tumor with the highest incidence in Caucasians worldwide. Presently, solar UV light is regarded as the most significant carcinogen for this tumor; however, not all basal cell carcinomas are caused by UV light, as these tumors are rare in certain anatomical areas subjected to intense UV radiation exposure throughout life (i.e., dorsal aspects of the hands) and commonly appear on relatively sun-protected skin localizations (i.e., eyelid, inner canthus, and retroauricular area) (145). In the pathogenesis of basal cell carcinomas, activating mutations of the hedgehog pathway at the cellular level are implicated (94,154), while at the tissue level, they act together with the induction of immune tolerance by the establishing tumor (immunosubversion) (172,178,352).…”

Section: Malassezia-produced Ahr Ligands and Significance Of Ahr Actimentioning

confidence: 99%

The Malassezia Genus in Skin and Systemic Diseases

et al. 2012

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SUMMARY In the last 15 years, the genus Malassezia has been a topic of intense basic research on taxonomy, physiology, biochemistry, ecology, immunology, and metabolomics. Currently, the genus encompasses 14 species. The 1996 revision of the genus resulted in seven accepted taxa: M. furfur , M. pachydermatis , M. sympodialis , M. globosa , M. obtusa , M. restricta , and M. slooffiae. In the last decade, seven new taxa isolated from healthy and lesional human and animal skin have been accepted: M. dermatis , M. japonica , M. yamatoensis , M. nana , M. caprae , M. equina , and M. cuniculi. However, forthcoming multidisciplinary research is expected to show the etiopathological relationships between these new species and skin diseases. Hitherto, basic and clinical research has established etiological links between Malassezia yeasts, pityriasis versicolor, and sepsis of neonates and immunocompromised individuals. Their role in aggravating seborrheic dermatitis, dandruff, folliculitis, and onychomycosis, though often supported by histopathological evidence and favorable antifungal therapeutic outcomes, remains under investigation. A close association between skin and Malassezia IgE binding allergens in atopic eczema has been shown, while laboratory data support a role in psoriasis exacerbations. Finally, metabolomic research resulted in the proposal of a hypothesis on the contribution of Malassezia -synthesized aryl hydrocarbon receptor (AhR) ligands to basal cell carcinoma through UV radiation-induced carcinogenesis.

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“…16 While their degree of importance as an SCC precursor is debated, actinic keratoses (AKs) occur at an earlier age and are the lesion underlying at least some SCCs; the time between developing baldness and developing scalp AKs in the UK averages 35 years. 17 However, for BCC, the position of BCC on the face does not correlate with the site-specific UVR exposure, 18 and migration studies and sun exposure questionnaire studies suggest that childhood sunburn and recreational UVR exposure in the 0-19 years age group appear to be critical for later BCC risk. 19,20 Thus prevention needs to be employed for several decades to have a significant impact.…”

Section: Biological Issuesmentioning

confidence: 99%

‘The Health of the Nation’ – an unattainable skin cancer target predictably remains beyond reach

Cox

2009

J R Soc Med

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Frequency of Facial Basal Cell Carcinoma Does Not Correlate With Site-Specific UV Exposure

Cited by 83 publications

References 25 publications

A comparison of sunlight exposure in men with prostate cancer and basal cell carcinoma

A comparison of sunlight exposure in men with prostate cancer and basal cell carcinoma

The Malassezia Genus in Skin and Systemic Diseases

‘The Health of the Nation’ – an unattainable skin cancer target predictably remains beyond reach

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