Frequency of extrasystoles in healthy male employees.

Orth‐Gomér, Kristina; Hogstedt, Christer; Bodin, L.; Söderholm, B

doi:10.1136/hrt.55.3.259

Cited by 32 publications

(8 citation statements)

References 16 publications

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“…Our data for the prevalence of ventricular dysrhythmias in healthy subjects is in agreement with other studies [14-18; see Table 2]. We detected less ectopic actvity than some other studies of healthy subjects undergoing ACM-but the subjects in these populations were somewhat older than ours and there is a well documented relationship of increasing ectopic frequency with increasing age [14][15][16].…”

Section: Discussionsupporting

confidence: 92%

Use of 24 h ambulatory ECG recordings in the assessment of new chemical entities in healthy volunteers.

Stinson

Pears

Williams

et al. 1995

Brit J Clinical Pharma

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1. Ambulatory (24 h) cardiac monitoring (ACM) is frequently used to screen healthy volunteers before inclusion in trials of new chemical entities in man. We analysed 156 consecutive ACM recordings in 'healthy' volunteers (on no medication). 2. Only 20 (13%) of the recordings showed normal sinus rhythm throughout. 3. Supraventricular ectopics were the commonest abnormality (83%). Ventricular ectopics occurred in 11%; ventricular tachycardia (unsustained) in 2% and sinus pauses in 6.5%. One volunteer was found to be in atrial fibrillation throughout. 4. The data indicate that when ACM recordings are performed in the assessment of the effects of experimental drugs, guidelines are needed to assess 'normality' to suggest when cardiological investigation is needed and to assign causality of the arrhythmia to the new chemical entity. 5. Proposed guidelines are presented.

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Section: Discussionsupporting

confidence: 92%

Use of 24 h ambulatory ECG recordings in the assessment of new chemical entities in healthy volunteers.

Stinson

Pears

Williams

et al. 1995

Brit J Clinical Pharma

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“…However, this is not conclusive because VT and VPBs including couplet beats have occasionally been found in several normal volunteers [23][24][25].…”

Section: Discussionmentioning

confidence: 86%

Holter Electrocardiogram Monitoring in Nephrotic Patients during Methylprednisolone Pulse Therapy

Fujimoto

Kondoh²,

Yamamoto³

et al. 1990

Am J Nephrol

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We assessed the effect of intravenous methylprednisolone pulse therapy (IMPT) on cardiac rhythm and electrolyte metabolism in patients with nephrotic syndrome. A total of 25 patients had valid evaluations with continuous ambulatory electrocardiograms, and 20 of these had simultaneous sodium and potassium clearances. No significant difference of frequency in complex ventricular arrhythmias (Lown’s grades 3–5) between the control and the therapy period was observed; however, 4 patients showed complex ventricular arrhythmias including ventricular tachycardia (2 patients) during the course of therapy. Fractional excretion of potassium and serum potassium significantly increased from baseline after IMPT. Complex ventricular arrhythmias, sometimes leading to sudden death, might ensue from IMPT. These dysrhythmias may be related to an abrupt change in potassium reflux from the cell.

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“…On the other hand, higher concentrations could induce tachycardia,6 and our findings of a possible effect among the medium exposed are not totally inconsistent with animal and human data. Nevertheless, the absence of a dose effect pattern and the lack of a relation between peak exposures (over 10 have any adverse effects on heart activity. One finding from a questionnaire survey we conducted among 248 refrigerator repairmen was that the reported frequency of palpitations was 120% which was not higher than in non-exposed reference groups.…”

Section: Discussionmentioning

confidence: 99%

Cardiac arrhythmia in refrigerator repairmen exposed to fluorocarbons.

Edling

Ohlson

Ljungkvist

et al. 1990

Occupational and Environmental Medicine

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A field study of 89 refrigerator repairmen was carried out to ascertain whether occupational exposure to fluorocarbons induces cardiac arrhythmia. The concentrations of fluorocarbons in the breathing zones and the heart activity were recorded simultaneously. Most cooling systems contained FC 12 or FC 22. The highest level recorded in one minute was 14 000 ppm and the highest time weighted level during eight hours was 280 ppm. Two types of arrhythmia were recorded, ectopic beats and sudden bradycardia. A within subject comparison design was applied and the main parameter was the difference in arrhythmia frequencies between exposed and unexposed periods. No appreciable differences between exposed and unexposed periods and no consistent dose effect relations were observed, although subjects in the medium exposure category showed a difference of borderline significance (Wilcoxon's test: p = 0-05, one tailed). The frequencies of arrhythmia when unexposed were somewhat higher than previously reported. Misclassification of the exposure and the possible confounding effect of physical workload and psychological strain may have obscured a causal relation and therefore a minor effect cannot be ruled out. The results do not support the notion that fluorocarbons induce cardiac arrhythmia in occupationally exposed refrigerator repairmen.Flurocarbons have been used industrially since the 1930s, and are generally known under their commercial names such as Freon, Arcton or Frigen. In

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Frequency of extrasystoles in healthy male employees.

Cited by 32 publications

References 16 publications

Use of 24 h ambulatory ECG recordings in the assessment of new chemical entities in healthy volunteers.

Use of 24 h ambulatory ECG recordings in the assessment of new chemical entities in healthy volunteers.

Holter Electrocardiogram Monitoring in Nephrotic Patients during Methylprednisolone Pulse Therapy

Cardiac arrhythmia in refrigerator repairmen exposed to fluorocarbons.

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