Frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss

Boots, Christina E.; Bernardi, Lia A.; Stephenson, Mary D.

doi:10.1016/j.fertnstert.2014.05.005

Cited by 116 publications

(70 citation statements)

References 24 publications

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“…An observational cohort study of women with recurrent early pregnancy loss reported that obese women had a 58% risk of euploid miscarriage compared with 37% in non-obese women. 25 Obese women are at increased risk of pregnancy affected by congenital anomalies. A systematic review and meta-analysis reported an increase in the following congenital anomalies in the offspring of obese compared with non-obese women: spina bifida (2.…”

Section: Increased Risk Of Spontaneous Abortion and Congenital Anomaliesmentioning

confidence: 99%

Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child

Catalano

Shankar

2017

BMJ

852

749

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Obesity is the most common medical condition in women of reproductive age. Obesity during pregnancy has short term and long term adverse consequences for both mother and child. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies. Metabolically, obese women have increased insulin resistance in early pregnancy, which becomes manifest clinically in late gestation as glucose intolerance and fetal overgrowth. At term, the risk of cesarean delivery and wound complications is increased. Postpartum, obese women have an increased risk of venous thromboembolism, depression, and difficulty with breast feeding. Because 50-60% of overweight or obese women gain more than recommended by Institute of Medicine gestational weight guidelines, postpartum weight retention increases future cardiometabolic risks and prepregnancy obesity in subsequent pregnancies. Neonates of obese women have increased body fat at birth, which increases the risk of childhood obesity. Although there is no unifying mechanism responsible for the adverse perinatal outcomes associated with maternal obesity, on the basis of the available data, increased prepregnancy maternal insulin resistance and accompanying hyperinsulinemia, inflammation, and oxidative stress seem to contribute to early placental and fetal dysfunction. We will review the pathophysiology underlying these data and try to shed light on the specific underlying mechanisms.

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Section: Increased Risk Of Spontaneous Abortion and Congenital Anomaliesmentioning

confidence: 99%

Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child

Catalano

Shankar

2017

BMJ

852

749

View full text Add to dashboard Cite

show abstract

“…Additionally, in an analysis of 204 miscarriages [79], women with BMI 25 kg/m 2 had a significant increase in euploid miscarriages compared with women with lower BMI, despite a similar mean age. More recently [80], a study of REPL (in which 117 women had subsequent miscarriages with chromosomal results) showed a 58% frequency of euploid miscarriage compared with 37% in nonobese women. As other causes of euploid miscarriage were excluded in this study, these results suggest that the excess risk of miscarriages in the overweight and obese population is independent of embryonic aneuploidy.…”

Section: Pregnancy Outcomesmentioning

confidence: 99%

Medical and surgical interventions to improve outcomes in obese women planning for pregnancy

Sharma

Bahadursingh

Ramsewak

et al. 2015

Best Practice & Research Clinical Obstetrics & Gynaecol

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“…Wang et al found that a higher rate of spontaneous miscarriage in PCOS patients was due to higher prevalence of obesity [11]. In addition, Boots et al found that obese women are more prone to have euploid miscarriage compared to non-obese controls [12]. Obesity is a common finding in Saudi women due to dietary habits and personal lifestyle.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Pregnancy Loss in Patients with Polycystic Ovary Syndrome: A Case Control Study

Ashaq¹,

Mazer²,

Qahtani³

2017

OJOG

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Objectives: To identify different biophysical and hormonal factors that could contribute to recurrent pregnancy loss in Saudi women who have been diagnosed with polycystic ovary syndrome. Study Design: Case-control study. Settings: Infertility clinic in Dammam Maternity and Children Hospital. Cases: PCOS patients with recurrent pregnancy loss. Controls: PCOS patients without recurrent pregnancy loss. Results: The prevalence of recurrent abortion in PCOS patients was 31%. There was no significant difference between the cases and the controls in the age, 33.1 years versus 31.9 years, BMI, 31.4 kg/m 2 versus 31.6 kg/m 2 respectively. There was no significant difference in the successful pregnancies outcome in cases and controls, term deliveries 84% versus 90%, preterm deliveries 10% versus 5%, twin pregnancy 6% versus 5% respectively. There was no significant difference in the hormonal profile (prolactin, LH, FSH, LH/FSH ratio, TSH, progesterone, testosterone) between cases and controls. Serum estradiol level was significantly lower in the cases compared to the controls, 55.5 pg/mL versus 83.9 pg/mL respectively (p < 0.01). Conclusion: PCOS patients with recurrent abortions had no significant increase in the age, BMI, preterm pregnancy, multiple gestation and ectopic pregnancy. The hormonal profile (prolactin, LH, FSH, LH/FSH ratio, TSH, progesterone, testosterone) was comparable between the cases and the controls, except for serum estradiol level, which was significantly lower in PCOS patients with recurrent abortions.

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Frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss

Cited by 116 publications

References 24 publications

Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child

Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child

Medical and surgical interventions to improve outcomes in obese women planning for pregnancy

Recurrent Pregnancy Loss in Patients with Polycystic Ovary Syndrome: A Case Control Study

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