Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005

Chez, Michael G.; Chang, Mina; Krasne, Valerie; Coughlan, Carolyn A.; Kominsky, Matthew; Schwartz, Aaron J.

doi:10.1016/j.yebeh.2005.11.001

Cited by 232 publications

(188 citation statements)

References 24 publications

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“…Consistent with this, treating IEDs can improve behaviour (Pressler, Robinson, Wilson, & Binnie, 2005). A prevalence of IEDs ranging from 6-60.7% has been found in ASD (Chez et al, 2006). Epileptiform EEG abnormalities seem to be more common than non-epileptiform abnormalities (Spence & Schneider, 2009).…”

Section: Eeg Abnormalitiesmentioning

confidence: 77%

Autistic characteristics in adults with epilepsy

Wakeford

Hinvest

Ring

et al. 2014

Epilepsy & Behavior

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Section: Eeg Abnormalitiesmentioning

confidence: 77%

Autistic characteristics in adults with epilepsy

Wakeford

Hinvest

Ring

et al. 2014

Epilepsy & Behavior

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“…Conversely, autistic behaviors can occur in children with severe early onset epilepsy. 7,8 Genetic conditions may also be associated with autism, but autism may be one feature of the condition that has other problems as well (e.g., tuberous sclerosis or fragile X syndrome). 9,10 Some genes, such as the tyrosine kinase receptor 7q31 metastasis receptor site (MET) gene, an immune related gene affecting tyrosine kinase that can be involved in CNS immune dysfunction, can double the risk of autism.…”

Section: Part 1: Immune System and Autism: Defining The Relationshipmentioning

confidence: 99%

“…As many as 50% to 60% of pre-school aged children with autism may develop epileptic spikes on their EEG, es-pecially in their sleep. 7 Researchers in epilepsy, such as Vezzani 60 and Vezzani and Granata 61 have shown that cytokine changes may be responsible for development of epileptic activity in animal and human tissue. Certain anti-inflammatory treatments or anti-epileptic drugs may alter some immune mechanisms.…”

Section: Human Evidence Of Ongoing Atypical Inflammatory Responsementioning

confidence: 99%

“…There are cases in which the EEG abnormalities and autistic traits have improved in children treated with drugs such as valproic acid. 7,[62][63][64] Although speculative at this time, further studies are warranted to determine whether ongoing immune dysfunction can be identified by (or correlates with) the eventual onset of epileptic activity on EEG in young children with autism, even in the absence of clinical seizures. The CSF cytokines and neurotransmitters and/or imaging studies would be needed to show correlation to phenotypic features and EEG findings.…”

Section: Human Evidence Of Ongoing Atypical Inflammatory Responsementioning

confidence: 99%

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Immune Therapy in Autism: Historical Experience and Future Directions with Immunomodulatory Therapy

Chez

Guido-Estrada

2010

Neurotherapeutics

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Summary: Autism affects 1 in 110 new births, and it has no single etiology with uniform agreement. This has a significant impact on the quality of life for individuals who have been diagnosed with autism. Although autism has a spectrum quality with a shared diagnosis, it presents a uniquely different clinical appearance in each individual. Recent research of suspected immunological factors have provided more support for a probable immunological process or for processes that may play a role in the acquisition of an autistic condition. These factors include prenatal, genetic, and postnatal findings, as well as the discovery of a dysfunctional chronic pro-inflammatory state in brain tissue and cerebrospinal fluid in subsets of autistic patients. These findings offer new theories that may lead to the development of disease modification or preventative therapeutic options in the near future. This article reviews prenatal, genetic, and observed immune aspects of the autism condition that may be risk factors in the presentation of the autistic clinical phenotype. Historical immune interventions in autism are reviewed and potential new therapies and interventions are discussed.

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“…However, epilepsy and autism are different in the respect in that epilepsy is episodic, while autistic features are not. But it should be noted that one study of 899 individuals with autism found that 61% of them had epileptiform activity during sleep, even though they did not have clinical seizures [2]. Generally the cognitive level is lower is those individuals who have autism/epilepsy.…”

mentioning

confidence: 99%