Frequency of elevation of C-reactive protein in atrial fibrillation

Anderson, Jeffrey L.; Maycock, Chloe A. Allen; Lappé, Donald; Crandall, Brian G.; Horne, Benjamin D.; Bair, Tami L; Morris, Steven; Li, Qunyu; Muhlestein, Joseph B

doi:10.1016/j.amjcard.2004.07.108

Cited by 127 publications

(84 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4,14 In addition, several studies have found an association between the inflammatory markers (IL-6 and CRP) and AF. [15][16][17] Cardiac surgery is associated with an acute-phase response marked by an increase in inflammatory markers throughout the postoperative period. The peak incidence of postoperative AF occurs on the second and third postoperative day 2 which coincides with the peak elevation in CRP concentrations.…”

Section: Discussionmentioning

confidence: 99%

Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass

Pretorius

Donahue

et al. 2007

Circulation

View full text Add to dashboard Cite

Background-Postoperative atrial fibrillation (AF), leading to significant morbidity and prolongation of hospital stay, complicates 20% to 40% of surgical procedures requiring cardiopulmonary bypass (CPB). This study tests the hypothesis that biomarkers predict the development of postoperative AF. Methods and Results-We enrolled 253 adult patients undergoing elective cardiac surgery requiring CPB and who were in sinus rhythm at the time of surgery. Blood samples were obtained for measurement of 21 biomarkers immediately after separation from CPB and administration of protamine. Patients who developed postoperative AF (67 subjects, 26.5%) were significantly older (PϽ0.001), more likely to have a remote history of AF (PϽ0.001), and tended to be more likely to have had valve surgery (Pϭ0.082). Plasminogen activator inhibitor-1 (Pϭ0.014), interleukin (IL)-6 (Pϭ0.019), and N-terminal prohormone brain natriuretic peptide (Pϭ0.028) concentrations were significantly higher in the blood of patients who developed postoperative AF. Logistic regression identified age (PϽ0.001), remote history of AF (Pϭ0.001), and postoperative PAI-1 (Pϭ0.036) as independent predictors of postoperative AF. When preoperative PAI-1 antigen concentrations were included in the model age (PϽ0.001), remote history of AF (PϽ0.001) and preoperative PAI-1 (Pϭ0.015) were identified as independent predictors of postoperative AF. The Chi-squared Automatic Interaction Detection (CHAID) model indicated that age was the primary determinant for the development of postoperative AF (17% in age Յ67.3 years versus 49% in age Ͼ67.3 years). Within younger patients (age Յ67.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass

Pretorius

Donahue

et al. 2007

Circulation

View full text Add to dashboard Cite

show abstract

“…Despite the identification of risk factors for developing AF, such as hypertensive heart disease and valvular heart disease [1], not all pathophysiologic mechanisms have yet been fully elucidated. A correlation of an inflammatory state with the occurrence of AF was proposed in 1997 [2], and recently a growing number of studies has shown an association between elevated C-reactive protein (CRP) levels and paroxysmal as well as permanent AF [3,4,5,6]. In fact, CRP is not only associated with the existence of AF, but it may also predict future development of AF [7].…”

Section: Introductionmentioning

confidence: 99%

New-Onset Atrial Fibrillation in Bacteremia Is Not Associated with C-Reactive Protein, but Is an Indicator of Increased Mortality during Hospitalization

Kindem¹,

Reindal²,

Wester³

et al. 2008

Cardiology

View full text Add to dashboard Cite

Background: Several studies have associated elevated C-reactive protein (CRP) levels to the occurrence of atrial fibrillation (AF). We sought to estimate the frequency and prognostic impact of AF in patients with bacteremia, and to study the possible association between AF and CRP as well as between AF and mortality in this population. Methods: We retrospectively evaluated patient charts of patients with bacteremia with Escherichia coli or Streptococcus pneumoniae admitted to the Aker University Hospital in Oslo between 1994 and 2004. Known cardiac risk factors for AF, signs and mode of conversion of AF, and, if applicable, date of death were registered, as were characteristics of infection, such as systemic inflammatory response syndrome and white blood cell count. Initial CRP values were categorized into 4 strata. Odds ratios of the 3 highest CRP categories compared with the lowest were obtained from logistic models adjusting for known cardiac risk factors for AF as well as possible factors that may have had an impact on the odds ratios for the different CRP levels. Cox regression analysis was used to compare new-onset AF and death during the first 2 weeks after hospitalization. Results: A total of 672 patient charts were studied; 104 patients (15.4%) had new-onset AF. Peak incidence of new-onset AF occurred on the day of admission. Peak CRP values were reached during the following 2 days. High CRP level at admission did not predict the occurrence of AF. The observed mortality was higher among patients with new-onset AF (p = 0.001) during the first 2 weeks after hospitalization, but this effect disappears when adjusted for relevant factors. Conclusions: The frequency of new-onset AF in bacteremia is substantial. Initial CRP levels or white blood cell count do not seem to predict new-onset AF, as opposed to systemic inflammatory response syndrome. On the other hand, in patients with bacteremia, new-onset AF should be viewed as an indicator of increased mortality and morbidity.

show abstract

“…6 The Cardiovascular Health Study identified a history of congestive heart failure, valvular heart disease and stroke, echocardiographic evidence of enlarged left atrial dimension, abnormal mitral or aortic valve function, treated systemic hypertension, and advanced age as independently associated with AF. 7 These findings have since been replicated worldwide (Table 1) in China, 8 Spain, [9][10][11][12] US, [13][14][15] Italy, 16 and Sweden. 17 Evidence of the risk of AF in hyperthyroidism has been found in the Cardiovascular Health Study, 18 a UK population-based study, 19 a systematic review, 20 and earlier research using the General Practice Research Database (GPRD).…”

Section: Af and Medical Risk Factorsmentioning

confidence: 77%

Predictors of incident atrial fibrillation and influence of medications: a retrospective case–control study

2011

View full text Add to dashboard Cite

Frequency of elevation of C-reactive protein in atrial fibrillation

Cited by 127 publications

References 18 publications

Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass

Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass

New-Onset Atrial Fibrillation in Bacteremia Is Not Associated with C-Reactive Protein, but Is an Indicator of Increased Mortality during Hospitalization

Predictors of incident atrial fibrillation and influence of medications: a retrospective case–control study

Contact Info

Product

Resources

About