Frequency of Efficacy of Metformin in Pregnant Female With Pcos With Regards to Development of Gestational Diabetes Mellitus

Abstract

Background
 Polycystic ovary syndrome (PCOS) is a significant gynecological problem manifested by raised androgen level, menstrual irregularities, and/or one or both ovaries having small cysts. Metformin has shown to have promising effects on PCOS and its several metabolic aspects. The metformin used as therapy in these patients during pregnancy have beneficial effects regarding development of GDM.
 Objective
 To determine the frequency of efficacy of metformin in pregnant female with PCOS with regards to development of Gestational Diabetes Mellitus
 Material and methods
 Setting: The study was conducted in Jinnah Hospital, Lahore
 Study design: Descriptive cross sectional study
 Study duration: Six months from: 04-06-2018 to 04-12-2018
 Data collection procedure: A total of 220 cases fulfilled the inclusion/exclusion criteria were enrolled. All cases were followed up till delivery for presence/absence of GDM. The frequency of efficacy in patients with PCOS was noted; all this information was recorded on a pre-designed proforma. Data was entered and analyzed in SPSS version for 16.0.
 Results
 The mean age of patients was 30.50±6.08years. About 36 (16.4%) females had parity 0, 51 (23.2%) had parity 1, 59 (26.8%) had parity 2, 42 (19.1%) had parity 3 and 32 (14.6%) had parity 4. The mean BMI of patients was 26.81±4.55kg/m2. Efficacy of metformin was achieved in 190 (86.4%) cases while in 30 (13.6%) cases efficacy could not be achieved.
 Conclusion
 It has been inferenced that metformin is effective in 86.4% cases in controlling blood sugar level among pregnant females.