Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon

Hawa, M.; Picardi, Antonio; Costanza, Flavia; D’Avola, Delia; Anguissola, Giuseppina Beretta; Guglielmi, Chiara; Mottini, Giovanni; Fezeu, Léopold; Mbanya, Jean Claude; Leslie, R. David; Pozzilli, Paolo

doi:10.1016/j.clim.2005.09.016

Cited by 21 publications

(13 citation statements)

References 25 publications

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“…In this urban clinic population with well-developed health facilities, it is unlikely that the low incidence is due to early deaths or misdiagnosis [2,3]. Our study also confirms previous data from SSA [12–14] of a lower prevalence of Abs in diabetes patients compared to reports from western populations [6,9,23,26]. In sharp contrast to the observations in Caucasian populations, the ZnT8A marker could not differentiate diabetes patients from controls in Cameroon.…”

Section: Discussionsupporting

confidence: 90%

“…In sharp contrast to the observations in Caucasian populations, the ZnT8A marker could not differentiate diabetes patients from controls in Cameroon. This leaves us with GADA as the most significant autoantibody marker for this population, as has been observed in a previous study in Cameroon [14]. Our observation that GADA positivity is associated with the absence of a family history of diabetes, is in agreement with the known higher familial clustering in (Ab − ) type 2 diabetes patients [27], versus a higher prevalence of sporadic type 1 diabetes cases, characterized by lower transmission rates to offspring (5 – 10%) [28].…”

Section: Discussionsupporting

confidence: 54%

“…Comparison of study results from SSA is difficult due to the differences in the inclusion criteria of study participants, or the diagnostic methods used for antibody determinations. Moreover, most of the study populations in SSA are handicapped by their low numbers, while including subjects who have longstanding diabetes [14], or are older than the pediatric population in most Caucasian studies. The present study was undertaken to investigate the occurrence of GADA, IA-2A and ZnT8A in newly diagnosed diabetes patients under age 40 from Cameroon, in relation to clinical disease phenotype and other biological markers of immune-mediated type 1 diabetes (C-peptide, HLA-DQ , ketonuria) in order to assess their potential contribution to disease classification and choice of treatment.…”

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confidence: 99%

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Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients

Asanghanwa

Gorus

Weets

et al. 2014

Diabetes Research and Clinical Practice

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Aims We investigated the prevalence of diabetes autoantibodies (Abs) in Cameroonian patients and controls, assessed their contribution in disease classification and compared results with data from Belgium. Methods Abs against GAD (GADA), IA-2 (IA-2A) and zinc transporter 8 (ZnT8A) were assessed in 302 recently diagnosed Cameroonian patients with diabetes and 184 control subjects without diabetes aged below 40 years. Results Only 27 (9%) Cameroonian patients were younger than 15 years. Overall, 29% of patients presented at least one diabetes-associated antibody versus 9% in healthy controls (24% versus 7% for GADA (p < 0.001), 10% versus 3% for IA-2A (p < 0.006); 4% versus 2% for ZnT8A). Ab+ patients had lower C-peptide levels (p < 0.001), were more often insulin-treated (p < 0.002) and were as frequently diagnosed with type 1 diabetes as Ab− patients. Only 43% of Ab+ patients aged 15–39 years were clinically classified as having type 1 diabetes in Cameroon vs 96% in Belgium (p < 0.001). Not one Ab+ Cameroonian patient carried HLA-DQ2/DQ8 genotype versus 23% of Belgian Ab+ patients (p < 0.001). Younger age at diagnosis and antibody positivity were independent predictors of insulin therapy. Ab+ Cameroonian patients were older (p < 0.001), had higher BMI (p < 0.001) and lower Ab titers than Belgian Ab+ patients. In ketonuric patients, prevalence of autoantibodies was similar as in non-ketonuric patients. Conclusions In Cameroonian patients with diabetes aged under 40 years, antibody-positivity is not clearly related to disease phenotype, but may help predict the need for insulin treatment.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 54%

mentioning

confidence: 99%

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Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients

Asanghanwa

Gorus

Weets

et al. 2014

Diabetes Research and Clinical Practice

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“…In another study, 47 type 1 diabetes patients from Cameroon were screened for GAD and IA-2 autoantibodies. 38 The mean disease duration was 3.3 years. Sixteen patients and three patients were GAD-and IA2-autoantibody-positive, respectively.…”

Section: Introductionmentioning

confidence: 99%

The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa

Padoa

2011

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Type 1 diabetes is a serious, debilitating disease, with life-threatening complications, and the financial burden associated with the management of this disease is enormous. Early diagnosis and intervention can improve morbidity and mortality. Unfortunately, in Africa, type 1 diabetes is poorly characterised, and there is sparse information regarding the aetiology and epidemiology of this disease. However, there is some evidence of a later age of onset in African type 1 diabetic patients, compared to European diabetics, and it is thought that the prevalence of type 1 diabetes is lower in African populations than in the Western world.

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“…Among those, are the Anti-TPO autoantibodies (anti TPO Ab) which were found in over 90% of patients with autoimmune hypothyroidism and 70% of patient with Graves' disease (Hawa et al, 2006). Moreover, a dose-response relation between radiation exposure and the prevalence of positive antithyroxiperoxidase antibodies was found in some studies (Völzke et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Thyroiditis Among Ionizing Radiation Exposed Workers in Cardiac Catheterization Units.

Sa¹,

Mansour²,

Mm³

et al. 2017

Egypt. J. Occup. Med.

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Introduction: It is well known that ionizing radiation (IR) exposure increases the risk of thyroid cancer; however less is known about its role in development of autoimmune thyroiditis. Aim of work: to investigate the thyroid gland functions, level of anti TPO among interventional cardiology team members searching for an association between the level of their occupational exposure to ionizing radiation and the thyroid gland integrity. Materials and methods: This work was carried out in Cardiac Catheterization Unit in National Heart Institute Center. The study comprised two groups, an exposed group of 47 cardiac catheterization workers (19 physicians, 15 nurses and 13 technicians) and a control group of 47 workers matched with the exposed group as regards age and sex. The studied groups were subjected to a detailed questionnaire, full clinical examinations. laboratory investigations in the form of serum thyroid stimulating hormone (TSH), Triiodothyronine (T3), Thyroxine (T4) and antithyroxiperoxidase antibodies (anti-TPO). Radiation exposure was monitored by digital dosimeter. Results: Dosimeter readings were higher among physicians followed by nurses and technicians. Statistically significant higher level of serum TSH, anti-TPO along with statistically significant lower levels of T3, were found among the exposed compared to control groups (P<0.05). Significant positive correlation was detected between the level of anti-TPO and TSH (r= 0.876 P<0.001). Moreover, a significant negative correlation was found between anti-TPO and each of T3 (r= -0.814 P<0.001) and T4 (r= -0.324 P<0.05). ANOVA and Post Hoc tests showed significantly higher level of anti-TPO with significantly lower levels of T3 among the physicians compared to control group. Conclusion: Autoimmune thyroiditis may be considered as one of the adverse health hazards of occupational exposure to ionizing radiation in cardiac catheterization units. Recommendations: We recommend the regular measurement of thyroid hormone especially TSH and anti-TPO to detect early affection of thyroid gland among radiation exposed workers.

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Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon

Cited by 21 publications

References 25 publications

Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients

Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients

The epidemiology and pathogenesis of type 1 diabetes mellitus in Africa

Autoimmune Thyroiditis Among Ionizing Radiation Exposed Workers in Cardiac Catheterization Units.

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