Frequency of Development of Aortic Valve Disease in Unrepaired Perimembranous Ventricular Septal Defects

Prenatally diagnosed isolated perimembranous ventricular septal defect: Genetic and clinical implications

“…The pVSD was characterized as small solely by qualitative estimation and as medium or large by both qualitative and quantitative estimation. A pVSD was defined as small if only color was detected passing through the septum with no visible gap/defect in greyscale 8 . Medium was defined as a pVSD that was visible both on greyscale and color and the pVSD measurement on the greyscale was up to 3 mm.…”

“…A pVSD was defined as small if only color was detected passing through the septum with no visible gap/defect in greyscale. 8 Medium was defined as a pVSD that was visible both on greyscale and color and the pVSD measurement on the greyscale was up to 3 mm. Large pVSD was defined as a pVSD measured in greyscale >3 mm.…”

Outcomes of aortic valve repair with ventricular septal defect closure: An elusive task

“…They found that only 1.5% of the patients needed surgery for aortic valve prolapse or AR, concluding that aortic valve involvement in patients with a perimembranous VSD is rare and that frequent follow-up may be unnecessary for the majority although their follow-up was not long. 3 There is another recent study from India involving patients with outflow VSDs and AR; interestingly, 48% of the patients had a perimembranous VSD. 4 In this report, it was shown that in patients with moderate or severe AR preoperatively a perimembranous VSD was found to be associated with worsening of AR during a mean follow-up period of 6.3 years, whereas a juxtaarterial VSD was not.…”

“…First, despite this study being from India, where supposedly the prevalence of a juxtaarterial VSD is higher than in western countries, 67% of the patients had a perimembranous VSD. Previous reports have described that the frequency of aortic valve prolapse or AR is less with a perimembranous VSD compared with a juxtaarterial VSD 2,3 . Padiyath et al 3 followed up 657 patients in the United States with an unrepaired perimembranous VSD for a median follow‐up period of 1.7 years.…”

“…Previous reports have described that the frequency of aortic valve prolapse or AR is less with a perimembranous VSD compared with a juxtaarterial VSD 2,3 . Padiyath et al 3 followed up 657 patients in the United States with an unrepaired perimembranous VSD for a median follow‐up period of 1.7 years. They found that only 1.5% of the patients needed surgery for aortic valve prolapse or AR, concluding that aortic valve involvement in patients with a perimembranous VSD is rare and that frequent follow‐up may be unnecessary for the majority although their follow‐up was not long 3 .…”