Frequency of depression among oncology outpatients and association with other symptoms

Rhondali, Wadih; Perceau, Élise; Berthiller, Julien; Saltel, P.; Trillet‐Lenoir, Véronique; Trédan, Olivier; Coulon, Jean Pierre; Bruera, Éduardo; Filbet, Marilène

doi:10.1007/s00520-012-1401-3

Cited by 42 publications

(43 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies also reported these associations. [6][7][8][9][10][11][12] Both fatigue and sleep disturbance are frequent findings among patients with anxiety and depression. It is likely that patients with mood disturbance have a higher awareness of sleep disturbance in a similar way as they have a higher awareness and reporting of fatigue and other symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…It is likely that patients with mood disturbance have a higher awareness of sleep disturbance in a similar way as they have a higher awareness and reporting of fatigue and other symptoms. [9][10][11][12] It is therefore possible that patients reporting sleep disturbance may have had enough objective sleep but wake up perceiving poor rest and fatigue in the morning because of their depression and anxiety. Our group had also found consistently more severe fatigue in the morning in ACP.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between Daytime Activity, Fatigue, Sleep, Anxiety, Depression, and Symptom Burden in Advanced Cancer Patients: A Preliminary Report

Yennurajalingam

Tayjasanant

Balachandran

et al. 2016

Journal of Palliative Medicine

Self Cite

View full text Add to dashboard Cite

Background: There is limited research in advanced cancer patients (ACP) regarding association between objectively measured daytime activity and sleep (as measured by actigraphy), patient characteristics, and cancer symptoms (fatigue, sleep, anxiety, depression, cachexia, and symptom distress scores [SDSs]). Objectives: Our aim of the study was to determine the association between mean daytime activity (MDTA) and the following items: fatigue (FACIT-F), SDSs (Edmonton Symptom Assessment Scale [ESAS]), sleep quality (Pittsburg Sleep Quality Index [PSQI]), objective sleep variables (OSV) (sleep onset, sleep efficacy, wake after sleep onset, total sleep time), anxiety and depression (Hospital Anxiety and Depression Scale [HADS]), body composition scores, and overall survival (OS). We also examined the association between sleep [PSQI and OSV scores] and FACIT-F, HADS, and ESAS. Methods: Secondary analysis of a recent clinical trial of cancer-related fatigue in advanced cancer (NCT00424099). Association between MDTA and OSV (measured by actigraphy) during the first week of the study and patient characteristics, symptoms (FACIT-F, ESAS, HADS, and PSQI), and OS were analyzed. Results: Seventy-nine eligible patients were evaluable. The median age was 57 years. Median MDTA was 248.43 counts/minute. Multivariate analysis shows that low MDTA was significantly associated with age, gender, Functional Assessment of Cancer Therapy (FACT)-Functional Well-Being (FWB), ESAS dyspnea, HADS-anxiety, and total sleep time. MDTA was not associated with FACIT-F ( p = 0.997) and OS ( p = 0.18). Sleep quality (PSQI) was significantly associated with FACIT-F, HADS, ESAS anxiety, and depression, but none of these variables was associated with OSV. Conclusion: In ACP, lower MDTA was significantly associated with age, gender, FACT-FWB, ESAS dyspnea, HADS-anxiety, and total sleep time. Both sleep quality and cancer-related fatigue scores were strongly associated with depression and anxiety. More research is needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between Daytime Activity, Fatigue, Sleep, Anxiety, Depression, and Symptom Burden in Advanced Cancer Patients: A Preliminary Report

Yennurajalingam

Tayjasanant

Balachandran

et al. 2016

Journal of Palliative Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…The cross-sectional nature of our study does not allow for the determination of directionality, therefore, physical symptoms may be the reason patients become depressed, or depressed patients may focus more on their physical symptoms. Other studies confirm this directional uncertainty, particularly for sleep and gastrointestinal disorders [4,5,74]. However, physical symptoms are also intrinsic burdens normally treated to alleviate suffering in palliative patients, regardless of their potential impact on depression.…”

Section: Discussionmentioning

confidence: 85%

Prevalence and risk factors of depressive symptoms in a Canadian palliative home care population: a cross-sectional study

Fisher

Seow

Brazil³

et al. 2014

BMC Palliat Care

View full text Add to dashboard Cite

BackgroundDepression in palliative care patients is important because of its intrinsic burden and association with elevated physical symptoms, reduced immunity and increased mortality risk. Identifying risk factors associated with depression can enable clinicians to more readily diagnose it, which is important since depression is treatable. The purpose of this cross-sectional study was to determine the prevalence of depressive symptoms and risk factors associated with them in a large sample of palliative home care patients.MethodsThe data come from interRAI Palliative Care assessments completed between 2006 and 2012. The sample (n = 5144) consists of adults residing in Ontario (Canada), receiving home care services, classified as palliative, and not experiencing significant cognitive impairment. Logistic regression identified the risk factors associated with depressive symptoms. The dependent variable was the Depression Rating Scale (DRS) and the independent variables were functional indicators from the interRAI assessment and other variables identified in the literature. We examined the results of the complete case and multiple imputation analyses, and found them to be similar.ResultsThe prevalence of depressive symptoms was 9.8%. The risk factors associated with depressive symptoms were (pooled estimates, multiple imputation): low life satisfaction (OR = 3.01 [CI = 2.37-3.82]), severe and moderate sleep disorders (2.56 [2.05-3.19] and 1.56 [1.18-2.06]), health instability (2.12 [1.42-3.18]), caregiver distress 2.01 [1.62-2.51]), daily pain (1.73 [1.35-2.22]), cognitive impairment (1.45 [1.13-1.87]), being female (1.37 [1.11-1.68]), and gastrointestinal symptoms (1.27 [1.03-1.55]). Life satisfaction mediated the effect of prognostic awareness on depressive symptoms.ConclusionsThe prevalence of depressive symptoms in our study was close to the median of 10-20% reported in the palliative care literature, suggesting they are present but by no means inevitable in palliative patients. Most of the factors associated with depressive symptoms in our study are amenable to clinical intervention and often targeted in palliative care programs. Designing interventions to address them can be challenging, however, requiring careful attention to patient preferences, the spectrum of comorbid conditions they face, and their social supports. Life satisfaction was one of the strongest factors associated with depressive symptoms in our study, and is likely to be among the most challenging to address.

show abstract

“…Depression was also more common among cancer patients who reported high levels of fatigue compared to those with less fatigue (Rhondali et al, 2012), but such associations raise questions about circularity (i.e., is the fatigue due to depression or vice versa). In short, although several studies have indicated a significant association between somatic symptoms and depression for patients with cancer, it is often unclear whether observed somatic symptoms are due to depression or cancer (or if depression exacerbates the perceived severity of somatic symptoms that may have originated in the cancer treatment experience).…”

Section: Resultsmentioning

confidence: 99%

Towards a new conceptualization of depression in older adult cancer patients: a review of the literature

Saracino

Rosenfeld

Nelson

2015

Aging & Mental Health

View full text Add to dashboard Cite

Objectives Identifying depression in older adults with cancer presents a set of unique challenges, as it combines the confounding influences of cancer and its treatment with the developmental changes associated with aging. This paper reviews the phenomenology of depression in older adults, and individuals diagnosed with cancer. Method PsychInfo, PubMed, Web of Science, and Google Scholar databases were searched for English-language studies addressing the phenomenology, symptoms, or assessment of depression in older adults and those with cancer. Results The Diagnostic and Statistical Manual for Mental Disorders (DSM) criteria that appear to be relevant to both older adults and cancer patients are anhedonia, concentration difficulties, sleep disturbances, psychomotor retardation/agitation, and loss of energy. Possible alternative criteria that may be important considerations included constructs such as loss of purpose, loneliness, and irritability in older adults. Among cancer patients, tearfulness, social withdrawal, and not participating in treatment despite ability to do so were identified as potentially important symptoms. Conclusions Current DSM criteria may not adequately assess depression in older cancer patients and alternative criteria may be important to inform the understanding and identification of depression in this population. Enhancing diagnostic accuracy of depression is important as both the over-diagnosis and under-diagnosis is accompanied with significant costs. Thus, continued research exploring the phenomenology and identifying effective indicators of depression in older cancer patients is needed.

show abstract

Frequency of depression among oncology outpatients and association with other symptoms

Cited by 42 publications

References 54 publications

Association between Daytime Activity, Fatigue, Sleep, Anxiety, Depression, and Symptom Burden in Advanced Cancer Patients: A Preliminary Report

Association between Daytime Activity, Fatigue, Sleep, Anxiety, Depression, and Symptom Burden in Advanced Cancer Patients: A Preliminary Report

Prevalence and risk factors of depressive symptoms in a Canadian palliative home care population: a cross-sectional study

Towards a new conceptualization of depression in older adult cancer patients: a review of the literature

Contact Info

Product

Resources

About