Frequency of dengue infection in febrile patients attended Dhaka Medical College Hospital during January to December, 2018

Sultana, Nusrat; Fatema, Naheed; Hossain, Mohammad Zaid; Rahman, Anisur; Nehar, Naznin; Yeasmin, Mst Marufa; Sharmin, Rabeya; Sweety, Afroza Akbar; Pervin, Monira

doi:10.3329/jdmc.v28i1.45765

Cited by 3 publications

(5 citation statements)

References 17 publications

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“…A study from a non-endemic zone of Bangladesh during the 2019 outbreak also reveals similar findings [32]. Our comparison of studies conducted in DMCH in 2008 [20], 2016 [21], 2018 [22], and the current study also reveals a decreasing proportion of bleeding manifestations (e.g., melena). Melena was the most common form of bleeding followed by gum bleeding in the current study.…”

Section: Discussionsupporting

confidence: 85%

“…Finally, three original articles that fulfilled the criteria (i.e. Outbreak report of 2008 by Arif et al [13], 2016 by Pervin et al [20]; 2018 by Sultana et al [21]) were used for data extraction and comparison with the latest outbreak of 2019. The collective variables data from each of the above-mentioned reports were compared, specifically for differences in clinical manifestations.…”

Section: Methodsmentioning

confidence: 99%

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Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Hasan¹,

Tabassum²,

Sharif

et al. 2021

BMC Infect Dis

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Background The clinical presentation of dengue fever had been observed to change with time since its first outbreak in 2000 in Bangladesh. This report showed the clinical presentation of the 2019 outbreak in Bangladesh along with its comparison to previous outbreaks witnessed in this region. Methods This hospital-based cross-sectional study was conducted in one of the largest tertiary care hospitals in Dhaka city. A total of 553 laboratory-confirmed and 194 probable dengue cases were interviewed. The clinical manifestation of the confirmed cases of the current outbreak was compared with three of the outbreak reports retrieved from the databases. R version 3.6.3 was used for data analysis. Results Among the confirmed cases, two-thirds were male (63.2%) and the average age was 27(± 11) years. Positive tests for NS1 and IgM were present in 99.6% (n = 525/527) and 82.6% (n = 38/46) of the cases, respectively. Thrombocytopenia was present in 66.1% of cases. Fever (100%) was common for all. Gastrointestinal (GIT) features, including abdominal pain (86.5%), anorexia and/or vomiting (69.6%), and Diarrhea (> 3 motions/day) (26.2%) were more frequent than typical rash and other pain symptoms. Hypotension was present in approximately a quarter of patients (25%). GIT features (anorexia, nausea, and/or vomiting) and hypotension were more common among adult participants while bleeding manifestation (melena and vaginal bleeding, p = 0.009 & 0.032) was more frequent in pediatric patients. Compared to outbreaks of 2008, 2016, and 2018, increasing trends in GIT symptoms e.g. anorexia, abdominal pain, and diarrhea were observed. While a negative trend in hemorrhagic manifestations (skin rash, melena, and conjunctival hemorrhage/hemorrhagic sclera) and arthralgia/joint pain were found. Conclusion The present outbreak was noticeably characterized by GIT symptoms and hypotension in addition to the typical clinical features like rash and pain symptoms. An increasing trend in GIT features and decreasing trend in hemorrhagic manifestations was noted over the last decade of dengue outbreaks.

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Section: Discussionsupporting

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Hasan¹,

Tabassum²,

Sharif

et al. 2021

BMC Infect Dis

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show abstract

“…Weakness, loose motion, loss of appetite, abdominal pain was also found in 14.8%, 5.4%, 7.1%, 3.9% patients respectively. Fever, headache, body pain, skin rash, vomiting/nausea-these are the most common symptoms that are typically seen in dengue patients and align with those found in related previous studies conducted in Dhaka (10,(25)(26)(27) . But some symptoms and complications found in the current study such as eye lesion/red eyes, seizures etc.…”

Section: Resultssupporting

confidence: 86%

“…were less common in dengue patients previously in Bangladesh. Red eye was found among dengue patients of the year 2000 (28) , but not reported in the studies conducted in Dhaka in 2006,2007,2008,2016, 2018 (26)(27)29) . This symptom was again evident in patients of 2019 (30) and 2021.…”

Section: Resultsmentioning

confidence: 98%

Clinical manifestations and seasonal occurrence of patients with dengue hospitalized at Dhaka city of Bangladesh in 2021

Barua,

Mahjuba,

Khan

et al. 2024

Dhaka Univ. J. Biol. Sci

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For the past few years, the intensity of dengue in Bangladesh has been rising. The current study was done among 533 dengue patients hospitalized in 2021 in Dhaka to observe the different aspects of clinical manifestations and seasonal occurrence of dengue. Due to COVID-19 restriction, hospital entry and face-to-face interview of the patients was not possible. Hence, contact numbers of the hospitalized dengue patients were collected from Directorate General of Health Services (DGHS) and patients were interviewed over the phone. Out of 533 patients, majority were from Dhaka south city corporation (DSCC) (53.7%), had a monthly household income of 30001≥ BDT (67.4%), and lived in small sized families (76.9%). High fever (p=0.013), headache (p<0.001), body pain (p<0.001), vomiting/nausea (p=0.0085), skin rash (p=0.033), eye lesion/red eyes (p=0.0011), pleural effusion (p=0.0404), weakness (p=0.017) and gum bleeding (p=0.014)- were significantly associated with age groups whereas vomiting/nausea (p=0.048), skin rash (p=0.002) and eye lesion/red eyes (p=0.032) were significantly associated with gender. 86.7% suffered from thrombocytopenia (<150000 per microliter blood), while 27% were in serious condition with lowest platelet count ≤ 20000 per microliter blood. 3.6% patients were admitted to ICU and 1.7% died of dengue. Death due to dengue was significantly associated with age groups (p <0.05) and majority among them were children (≤ 10 years). Family members of 44.6% patients were also affected with dengue and majority of the patients belonged to small sized families. Dengue occurrence had significant association with season where majority of the patients were from monsoon season (65.29%) followed by post-monsoon (33.21%) season. Dengue manifests a wide spectrum of symptoms as shown by the study, so now it is necessary to identify the changes in pattern of the clinical manifestations, and effective disease management to lessen the severity of the outbreak. Dhaka Univ. J. Biol. Sci. 33(1): 33-46, 2024 (January)

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“…Likewise, the majority (62%) of the confirmed case belonged to the 16–30 age group, with a mean age of 29 years in the 2002 outbreak [ 21 ]. Older adolescents and young adults also comprised the majority of the cases in 2016 (21–40; 55%), 2018 (15–29; 65%), and 2019 (21–40; 50%) outbreaks [ 28 – 30 ]. A similar result was reported in Sri Lanka in 2018 [ 31 ] and Ethiopia in 2017 [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Twenty-two years of dengue outbreaks in Bangladesh: epidemiology, clinical spectrum, serotypes, and future disease risks

et al. 2023

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Dengue is the most rapidly spreading mosquito-borne disease and has become a major public health threat, particularly for tropical and subtropical countries including Bangladesh. This comprehensive review aims to summarize the overall scenario of dengue, including disease burden, clinical spectrum, seroprevalence, circulating serotypes/genotypes, and spatial distribution since the first recorded outbreak in Bangladesh. Since the first recorded outbreak in 2000, dengue epidemiology has shown the typical epidemic pattern with more frequent and bigger outbreaks and gradual geographic expansion to non-endemic regions in Bangladesh. For instance, highly confined Rohingya refugee camps that provide shelters to nearly 1.2 million forcibly displaced vulnerable Myanmar nationals in Cox’s Bazar district confronted a massive outbreak in 2022. Recent major outbreaks are found to be associated with the emergence of serotype DENV-3, which was undetected for a long time. Consequently, changes in serotypes might be attributed to increased severity in clinical manifestation in recent years. The existing weak surveillance and risk management systems are inadequate to deal with impending dengue risks. The healthcare system, particularly at the district level, is not prepared to manage impending large-scale dengue outbreaks in Bangladesh. Our findings would contribute to the development of strategies for dengue control and management in Bangladesh as well as other similar settings elsewhere in the world.

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Frequency of dengue infection in febrile patients attended Dhaka Medical College Hospital during January to December, 2018

Cited by 3 publications

References 17 publications

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Comparison of clinical manifestation of dengue fever in Bangladesh: an observation over a decade

Clinical manifestations and seasonal occurrence of patients with dengue hospitalized at Dhaka city of Bangladesh in 2021

Twenty-two years of dengue outbreaks in Bangladesh: epidemiology, clinical spectrum, serotypes, and future disease risks

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