Frequency of Cytogenetic Findings and its Effect on the Outcome of Pediatric Acute Lymphoblastic Leukemia

Bahoush, Gholamreza; Nojoomi, Marzieh

doi:10.5455/medarh.2019.73.311-315

Cited by 9 publications

(14 citation statements)

References 15 publications

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“…In the present study, 57.9% (2182 patients) of the disease were observed in boys and the sex ratio of males to females was 1.37. These results are consistent with other studies; other studies showed higher incidence of disease in boys than in girls [4,9,[24][25][26]. According to the American Cancer Society's 2019 report, 55 percent of new cases and 56 percent of ALL deaths were boys [27].…”

Section: Discussionsupporting

confidence: 91%

Temporal trend and spatial distribution of acute lymphoblastic leukemia in Iranian children during 2006 -2014: A Mixed Ecological Study

et al. 2020

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The most common type of childhood cancers is acute lymphoblastic leukemia (ALL). The present study was conducted to determine the spatial-temporal epidemiological status of ALL in Iran. METHODS: Using an exploratory mixed design, this ecological study examined 3769 under-15 children with ALL who were reported in the National Cancer Registry of Iran during 2006 to 2014. Data were analyzed using the Mann-Whitney U, Getis-Ord General G (GOGG), Optimized hot spot analysis (OHSA), and the Pearson correlation coefficient (PCC) at α2 range and the significance level of 0.05. RESULTS: The average annual incidence rate of the disease was 2.25 and the cumulative incidence rate was 21.31 per 100,000 under-15 children. The mean and standard deviation (SD) of patients' age were 5.90 ±3.68 and the peak incidence was observed among 2-5-year olds. No significant difference in the mean age between boys and girls (P = 0.261). The incidence of ALL was seasonal and more common during spring and summer. The Getis-Ord General G index was 0.358 and significant (P-value <0.001). Hot spots were identified in south, central and eastern Iran and cold spots in north and west of Iran. PCC between CIR and latitude was negative (r=-0.5086 P=0.0035) but between CIR and longitude was positive (r= 0.3474 P =0.0555). CONCLUSIONS: Compared to developed countries, the incidence of ALL in Iranian children is lower but increasing. Can be argued that the incidence of ALL is due to the synergism interaction between environmental, infectious, geographical and genetic risk factors.

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Section: Discussionsupporting

confidence: 91%

Temporal trend and spatial distribution of acute lymphoblastic leukemia in Iranian children during 2006 -2014: A Mixed Ecological Study

et al. 2020

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“…26 Other studies have estimated the incidence rate of ALL to be between 3 and 7 per 100 000 children. 20,[27][28][29] In the present study, the mean and standard deviation of age were 5.90 ± 3.68 with a median age of 5 years. There was no statistically significant difference in age distribution between male and female children.…”

Section: Discussionmentioning

confidence: 82%

“…15,39 The highest incidence was observed between 2 and 5 years of age. In the studies by Hjalgrim et al, 40 Dohner et al, 41 Bahoush et al, 27 and Alrudainy et al, 42 the peak incidence of the disease was reported to be at the age of 2-5 years.…”

Section: Discussionmentioning

confidence: 95%

“…These results are consistent with those reported in other studies according to which the incidence rate of ALL was higher in males than females. 9,20,27,29 According to American Cancer Society, 55% of new cases and 56% of ALL deaths are related to male children. 30 In summary, as expected, the demographic data obtained from Iranian children with ALL resemble those of children with ALL in the rest of the world.…”

Section: Discussionmentioning

confidence: 99%

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Geographical Pathology of Acute Lymphoblastic Leukemia in Iran with Evaluation of Incidence Trends of This Disease Using Joinpoint Regression Analysis

et al. 2021

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Background:The aim of present study is to determine the spatial-temporal epidemiology of acute lymphoblastic leukemia (ALL) in Iranian children. Methods: This ecological study was performed using an exploratory mixed design. The study population consists of 3769 children with ALL who were reported in the National Cancer Registry Program of Iran from 2006 to 2014. Data analysis was conducted using Mann-Whitney U, joinpoint regression analysis, Global Moran's I and Anselin Local Moran's I. Results: The average annual incidence rate of ALL was 2.25 per 100 000 children under 15 years of age during the study period, which was 1.37 times higher in males. The average annual percentage change (AAPC) of the disease was 7.1%, which is higher than that of developed countries. The incidence of ALL was higher in spring and summer and its peak incidence was at the age of 2-5. Spatial autocorrelation of the ALL was 0.358 and significant (P value <0.001). The high-risk cluster of ALL was identified in Fars and Kohgiluyeh and Boyer-Ahmad provinces and the low-risk cluster in Kermanshah, Zanjan and Kurdistan provinces. Conclusion:The incidence of ALL is on rise in Iranian children and appropriate healthcare services are required to prevent new cases of this disease in high-risk areas.

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“…Leukemia ranks rst in incidence among pediatric malignancies, and is a major disease that seriously threatens the lives and health of children [1]. From 2016 to 2018, the average annual incidence of leukemia among children aged 0-14 in China was 42.9 per million and the number of leukemia cases every year was about 8,000 [2].…”

Section: Introductionmentioning

confidence: 99%

The Manifestations of Social Maladjustment in Children With leukemia at Different Ages: A Descriptive Qualitative Study based on Phenomenology

Tang

Liu

et al. 2021

Preprint

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Background Leukemia is a pediatric malignancy with the highest incidence rate and large onset age span. Children with leukemia at different ages show various social maladjustments after illness, which are mainly reflected in psychological and behavioral changes. It is of great significance to improve children's social adaptation level and purposefully prevent children from having social adaptation problems. Objective To describe the social adaptation problems faced by Chinese children with leukemia at different ages, and to provide the basis for formulating targeted preventive intervention strategies. Method The purpose sampling method was adopted to conduct semi-structured interviews on 20 Chinese children with leukemia and their main caregivers, and the Colaizzi phenomenological research method in the qualitative research was used to organize and analyze the data. Results The existing social adaptation problems of children with leukemia at different ages were summarized. In terms of psychological maladjustment, children with leukemia aged 2~7 years showed "fear and excessive attachment"; Children with leukemia aged 8-18 years are characterized by "Impatience, irritability and anxiety". In terms of behavioral maladjustment, children with leukemia aged 2~7 years have the problem of "less independent behavior" and "dependence on electronic products"; Children with leukemia aged 8-18 years showed "learning obstruction" and "indulging in mobile games". Conclusions Develop targeted intervention strategies based on the physical and mental characteristics of children with leukemia at different ages to improve their existing social adaptation problems. Pay attention to early intervention in the social adaptation of children with leukemia. Predictably improve the social adaptation level of children to prevent more adaptation problems, so that children can smoothly return to their families and society and improve their quality of life in the long term.

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Frequency of Cytogenetic Findings and its Effect on the Outcome of Pediatric Acute Lymphoblastic Leukemia

Cited by 9 publications

References 15 publications

Temporal trend and spatial distribution of acute lymphoblastic leukemia in Iranian children during 2006 -2014: A Mixed Ecological Study

Temporal trend and spatial distribution of acute lymphoblastic leukemia in Iranian children during 2006 -2014: A Mixed Ecological Study

Geographical Pathology of Acute Lymphoblastic Leukemia in Iran with Evaluation of Incidence Trends of This Disease Using Joinpoint Regression Analysis

The Manifestations of Social Maladjustment in Children With leukemia at Different Ages: A Descriptive Qualitative Study based on Phenomenology

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