Frequency of coincident iron deficiency and beta-thalassaemia trait.

Madan, N; Sikka, Meera; Sharma, Satendra; Rusia, Usha

doi:10.1136/jcp.49.12.1021-b

Cited by 5 publications

(5 citation statements)

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“…The estimated prevalence of BTT in different regions of India is reported to vary between 2.7% and 14.9% (mean: 4.5%) [1,2]. Most individuals with BTT are asymptomatic and are identified incidentally when their complete blood count (CBC) shows microcytosis [3].…”

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confidence: 99%

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A Search for Beta Thalassemia Trait in India

Parthasarathy

2012

Turk J Hematol

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confidence: 99%

“…Detailed clinical history, CBC, blood smear, quantitative assessment of hemoglobin A2 (HbA2), and serum ferritin were evaluated in all cases. An HbA2 concentration >3.5% was considered diagnostic of BTT [1,6]. Iron deficiency was diagnosed based on a ferritin level <15 ng/mL [7].…”

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confidence: 99%

A Search for Beta Thalassemia Trait in India

Parthasarathy

2012

Turk J Hematol

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“…High Performance Liquid Chromatography was used for quantization of HbA2 because of the simplicity of sample preparation, superior resolution, and accuracy, combined with complete automation of the method. 8 Diagnosis of BTT was based on levels of HbA2 greater than 3.7%. Reduction of HbA2 because of coincident iron deficiency did not preclude detection of BTT.…”

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confidence: 99%

Prevalence of thalassemia and hemoglobinopathy in antenatal mothers with relation to complete hemogram and high performance liquid chromatography-a hospital based study of Eastern India

Chowdhury

Talukdar

2018

Int J Res Med Sci

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Background: Iron deficiency anemia (IDA) and Beta thalassemia (BT) are two most common causes of microcytic hypochromic anemia in our country affecting the reproductive age group. It is important to discriminate between these two entities to prevent treatment with iron of individuals with thalassemia trait as well as prevent homozygous transmission of B thalassemia trait (BTT). Aim of the study was to investigate causes of microcytic anemia in antenatal mothers and to find out the role of Cell Counter and High Performance Liquid Chromatography (HPLC) so as to screen BTT and other hemoglobinopathies.Methods: This study was done over a period of six months (May 2017 to October 2017) in the Department of Pathology in R. G. Kar Medical College. We analyzed the blood samples of all antenatal mothers attending Department of Pathology for blood tests and a complete hemogram and hemoglobin A2 (Hb A2) quantitation was done.Results: Total cases evaluated were 2200 of which 442 patients were found to have microcytic hypochromic anemia (MCV<80%, MCH<27). Rest that is 1758 was normal. Of 442 cases of microcytic hypochromic anemia, 205 were found to have IDA, 115 BTT, 112 E trait, 1 case each of Hemoglobin E disease, E-Beta thalassemia and hereditary persistence of fetal hemoglobin (HPFH). Hemoglobinopathies like S trait and Hemoglobin J (Hb J) was found in 4 and 3 cases respectively.Conclusions: In India, Microcytic hypochromic anemia is common and may be due to IDA, BTT or other hemoglobinopathies Cell counter-based parameters and formulas, along with HPLC can be an effective method of thalassemia screening in a society.

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“…[ 23 ] Reduction of HbA2 because of coincident iron deficiency did not preclude detection of BTT. [ 24 ]…”

Section: Discussionmentioning

confidence: 99%

Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening

Tiwari¹,

Chandola²

2009

Asian J Transfus Sci

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Background:The prevalence of microcytosis in donors and Iron Deficiency Anemia (IDA) and Beta-Thalassemia trait (BTT) in microcytic and non-microcytic donors has not been studied in India. The present study aims at finding the same.Materials and Methods:Initially 925 donor samples were evaluated on cell-counter. Of these, 50 were found to be microcytic. These were subjected to Ferritin and HbA2 determination. Subsequently, an additional 51, age-and-sex matched non-microcytic donor samples were selected to serve as controls. These were subjected to the same tests.Results:The prevalence of microcytosis was 5.4% (50/925). Among the microcytic donors, 52% were IDA, 36% BTT, 8% both, and 4% none. In case of non-microcytic donors 29.4% were IDA, 3.9% BTT, and 66.7% none.Conclusions:The study revealed a high prevalence of IDA and BTT in blood donors and a higher probability of finding these in the microcytic samples. This prompted authors to suggest an algorithm for screening of blood donors for IDA and BTT. The algorithm recommends doing an hemogram on all donor samples, routinely. Ferritin could be done only in microcytic samples. At levels lower than15 ng/ml, it is diagnosed as IDA, and therefore, HPLC is performed only for non-IDA samples with Ferritin levels higher than 15 ng/ml. By employing this algorithm, a substantial number of IDA and BTT could be diagnosed while keeping the number of Ferritin tests small and the number of HPLC tests even smaller and thus making it cost efficient.

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Frequency of coincident iron deficiency and beta-thalassaemia trait.

Cited by 5 publications

References 5 publications

A Search for Beta Thalassemia Trait in India

A Search for Beta Thalassemia Trait in India

Prevalence of thalassemia and hemoglobinopathy in antenatal mothers with relation to complete hemogram and high performance liquid chromatography-a hospital based study of Eastern India

Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening

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