Frequency of chromosomes carrying endogenous retroviruses in the populations of domestic pig and wild boar

Nikitin, S. V.; Yudin, N. A.; Knyazev, S. P.; Aytnazarov, R. B.; Кобзев, В. Ф.; Bekenev, V. A.; Savina, Maria A.; Yermolaev, V. I.

doi:10.1134/s1022795408060082

Cited by 8 publications

(15 citation statements)

References 9 publications

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“…There are the differences between wild boars and domestic pigs, as well as between the wild boars of West Europe and Central Asia, in terms of the frequency of occurrence of individuals with chromosome carriers of PERV and their combinations (Jin et al, 2000;Nikitin et al, 2008;Aitnazarov et al, 2010).…”

Section: Molecular Genetic Characteristics Of Pervmentioning

confidence: 95%

“…Analysis of PERV in domestic porcine breeds has shown that though the A and B types of PERV pre vail in the genomes of all the studied breeds, there are still often seen animals with no PERV of the C type (Bosh et al, 2000;Nikitin et al, 2008;Yudin et al, 2009;Aitnazarov et al, 2010;Nikitin et al, 2010). There are the differences between wild boars and domestic pigs, as well as between the wild boars of West Europe and Central Asia, in terms of the frequency of occurrence of individuals with chromosome carriers of PERV and their combinations (Jin et al, 2000;Nikitin et al, 2008;Aitnazarov et al, 2010).…”

Section: Molecular Genetic Characteristics Of Pervmentioning

confidence: 98%

“…In addition, these associations can be either present or absent dependent on the specific por cine breed considered. Statistical analysis of the fre quency of occurrence of such chromosome carriers as PERV A, PERV B, and PERV C has shown that PERV chromosome carriers and haplotypes consisting of two or three PERV types are more frequent in domestic pigs than in wild boars (Nikitin et al, 2008).…”

Section: Molecular Genetic Characteristics Of Pervmentioning

confidence: 99%

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Porcine endogenous retroviruses: What are the risks of infection transmission in xenotransplantation?

Yudin

Aitnazarov

Ermolaev

2011

Russ J Genet Appl Res

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Modern studies on porcine endogenous retroviruses are considered in the review. Data on the nucleotide sequences of retroviruses, their expression, and the isolation of mature virions is discussed. The tropism of endogenous retroviruses to human cells and retrospective studies of patients are considered in detail. A critical overview of works on in vitro and in vivo interspecific transmission of porcine endogenous retroviruses is presented. Tactics for preventing possible infection and treating humans for it are discussed. Based on the overviewed data, it is concluded that the risk of infection transmission from xenograft recipients to the rest of the population is very low. This low risk can be further reduced by careful observation and, prob ably, vaccination of contacting persons, as well as by preventive use of antiviral drugs. The minor risk of infec tion transmission can also be reduced by application of modern biotechnological methods to raise pigs that have no endogenous viruses tropic to humans.

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Section: Molecular Genetic Characteristics Of Pervmentioning

confidence: 95%

Section: Molecular Genetic Characteristics Of Pervmentioning

confidence: 98%

Section: Molecular Genetic Characteristics Of Pervmentioning

confidence: 99%

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Porcine endogenous retroviruses: What are the risks of infection transmission in xenotransplantation?

Yudin

Aitnazarov

Ermolaev

2011

Russ J Genet Appl Res

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“…We have previously shown that PERV retroviruses of all the three types are widespread in Siberian mini pigs (Nikitin et al, 2008). The enrichment of the genomes of miniature pigs with retroviruses is proba bly because they were introduced from speciesfounders.…”

Section: Introductionmentioning

confidence: 99%

Identification of whole genomes of endogenous retroviruses in Siberian miniature pigs

Aitnazarov

Yudin

Nikitin

et al. 2014

Russ J Genet Appl Res

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“…However, the qualitative traits are mostly estimated as more simple because of a strong concordance of each specific genotype to a single phenotype according to the «one genotype-one phenotype» principle. For long time of our studying variations of qualitative traits the results of both practical and theoretical interest have been obtained (13)(14)(15)(16)(17). Importantly, once the quantitative trait changes were first statistically analyzed, a number of genetic determinations peculiar specifically to domestic animals were found out (18).…”

Section: Introductionmentioning

confidence: 99%

Changes of Vectors of Selection for Piglet's Newborn Weight During Population Formation in New Environment Conditions

Knyazev¹,

Nikitin²

2014

S-h. biol.

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A b s t r a c tStudying changes of gene pools of populations of the domestic animals caused by selection and reflecting micro evolutionary processes, represents both practical and theoretical interest. As a rule, in such works the qualitative traits controlled by the principle «one genotype -one phenotype» are used that significantly simplifies the analysis. We investigated dynamic processes in Landrace population of domestic pigs (Sus scrofa domesticus), having estimated a variation of one of continuous quantitative traits, the newborn piglet weight, for which similar relationship is not unambiguous. Statistical analysis of the zootechnical register data was carried out on more than 26 thousand pigs that were born within 23 years at an experimental farm (Novosibirsk Province), being the regional authorized Landrace breed nucleus. Ancestors of the formed population were delivered from Latvia in the early 1960s. They were the elite young animals estimated on a standard complex of selection traits. The entire period of existence of population the formation of its breeding nuclear was carried out on a complex of traits according to existing Instruction for estimation of breeding value of pigs. As the Instruction didn't contain standards on a large newborn weight, the selection on the specified trait wasn't made. The changes of statistical parameters of the newborn weight in piglets were estimated for each year of the observation, because the analyzed livestock was not a model laboratory population, but a typical breeding commercial herd in which continuous variability of a trait is interfaced to continuous «sliding» alternations of generations and the variability of age structure. During long-time analysis of the dynamics of this unselected trait, the directional (moving) selection on genotypes for the loci controlling growth rate of pigs in ontogenesis (in pre-and post-natal periods) is revealed. In the populations where such selection works, the newborn weight of piglets can be used for forecasting pig weight during the postnatal period. Application of «parent-descendant» regression on the newborn weight allowed to estimate the duration of a population gene pool adaptation to new environment. It appeared that process of adaptation lasted nearly two decades that made five full changes of the generations. In the same population at the same time the stabilizing selection optimized an individual animal weight at birth, cutting both minimum and maximum values. The described mechanism includes cyclic vector changes towards driving selection against the stabilizing selection vectors and thus maintains the population polymorphism on loci which control prenatal growth and large weight in the newborns. An observed unevenness of wavy change of these cycles should be also noted.

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Frequency of chromosomes carrying endogenous retroviruses in the populations of domestic pig and wild boar

Cited by 8 publications

References 9 publications

Porcine endogenous retroviruses: What are the risks of infection transmission in xenotransplantation?

Porcine endogenous retroviruses: What are the risks of infection transmission in xenotransplantation?

Identification of whole genomes of endogenous retroviruses in Siberian miniature pigs

Changes of Vectors of Selection for Piglet's Newborn Weight During Population Formation in New Environment Conditions

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