Frequency of Autoimmune Diseases in Myasthenia Gravis: A Systematic Review

Mao, Zhifeng; Yang, Long-Xiu; Mo, Xiaoting; Qin, Chao; Lai, Yongrong; He, Ning-Yu; Li, Tong; Hackett, Maree L.

doi:10.3109/00207454.2010.539307

Cited by 98 publications

(105 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The male predominance in GBS differs from that of most other autoimmune diseases such as multiple sclerosis and systemic lupus erythematosus, which frequently demonstrate higher rates in females [37,38] . The reason for the higher risk of GBS in males is unknown.…”

Section: Discussionmentioning

confidence: 93%

Population Incidence of Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis

Sejvar

Baughman²,

Wise³

et al. 2011

Neuroepidemiology

776

601

View full text Add to dashboard Cite

Population incidence of Guillain-Barré syndrome (GBS) is required to assess changes in GBS epidemiology, but published estimates of GBS incidence vary greatly depending on case ascertainment, definitions, and sample size. We performed a meta-analysis of articles on GBS incidence by searching Medline (1966–2009), Embase (1988–2009), Cinahl (1981–2009) and CABI (1973–2009) as well as article bibliographies. We included studies from North America and Europe with at least 20 cases, and used population-based data, subject matter experts to confirm GBS diagnosis, and an accepted GBS case definition. With these data, we fitted a random-effects negative binomial regression model to estimate age-specific GBS incidence. Of 1,683 nonduplicate citations, 16 met the inclusion criteria, which produced 1,643 cases and 152.7 million person-years of follow-up. GBS incidence increased by 20% for every 10-year increase in age; the risk of GBS was higher for males than females. The regression equation for calculating the average GBS rate per 100,000 person-years as a function of age in years was exp[–12.0771 + 0.01813(age in years)] × 100,000. Our findings provide a robust estimate of background GBS incidence in Western countries. Our regression model may be used in comparable populations to estimate the background age-specific rate of GBS incidence for future studies.

show abstract

Section: Discussionmentioning

confidence: 93%

Population Incidence of Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis

Sejvar

Baughman²,

Wise³

et al. 2011

Neuroepidemiology

776

601

View full text Add to dashboard Cite

show abstract

“…Comorbidities with some of these diseases exist for alopecia areata [428], [429], vitiligo [430], [430,431], juvenile idiopathic arthritis [432], myasthenia gravis [433], [434], and Addison's disease [435], five additional PTPN22 -associated diseases, as well as celiac disease [436], [437] and pernicious anemia [438], [439]. A link between GD and CAD is potentially confounded by the anti-atherogenic properties of thyroid hormones [440].…”

Section: Resultsmentioning

confidence: 99%

Coherent Somatic Mutation in Autoimmune Disease

Ross

2014

PLoS ONE

View full text Add to dashboard Cite

BackgroundMany aspects of autoimmune disease are not well understood, including the specificities of autoimmune targets, and patterns of co-morbidity and cross-heritability across diseases. Prior work has provided evidence that somatic mutation caused by gene conversion and deletion at segmentally duplicated loci is relevant to several diseases. Simple tandem repeat (STR) sequence is highly mutable, both somatically and in the germ-line, and somatic STR mutations are observed under inflammation.ResultsProtein-coding genes spanning STRs having markers of mutability, including germ-line variability, high total length, repeat count and/or repeat similarity, are evaluated in the context of autoimmunity. For the initiation of autoimmune disease, antigens whose autoantibodies are the first observed in a disease, termed primary autoantigens, are informative. Three primary autoantigens, thyroid peroxidase (TPO), phogrin (PTPRN2) and filaggrin (FLG), include STRs that are among the eleven longest STRs spanned by protein-coding genes. This association of primary autoantigens with long STR sequence is highly significant (). Long STRs occur within twenty genes that are associated with sixteen common autoimmune diseases and atherosclerosis. The repeat within the TTC34 gene is an outlier in terms of length and a link with systemic lupus erythematosus is proposed.ConclusionsThe results support the hypothesis that many autoimmune diseases are triggered by immune responses to proteins whose DNA sequence mutates somatically in a coherent, consistent fashion. Other autoimmune diseases may be caused by coherent somatic mutations in immune cells. The coherent somatic mutation hypothesis has the potential to be a comprehensive explanation for the initiation of many autoimmune diseases.

show abstract

“…Concurrent autoimmune diseases are relatively distinct in MG, with variation in different subgroups (46). Nonmotor symptoms such as pure red cell aplasia, alopecia areata and immunodeficiency in MG are often overlooked, some of which might be mediated by cellular immunity, different from typical symptoms mediated by pathogenic autoantibodies (47).…”

Section: Relative Precision In the Main Domains Of Myasthenia Gravis mentioning

confidence: 99%

Precision medicine in myasthenia graves: begin from the data precision

Hong

Xie

et al. 2016

Ann. Transl. Med.

View full text Add to dashboard Cite

Myasthenia gravis (MG) is a prototypic autoimmune disease with overt clinical and immunological heterogeneity. The data of MG is far from individually precise now, partially due to the rarity and heterogeneity of this disease. In this review, we provide the basic insights of MG data precision, including onset age, presenting symptoms, generalization, thymus status, pathogenic autoantibodies, muscle involvement, severity and response to treatment based on references and our previous studies. Subgroups and quantitative traits of MG are discussed in the sense of data precision. The role of disease registries and scientific bases of precise analysis are also discussed to ensure better collection and analysis of MG data.

show abstract

Frequency of Autoimmune Diseases in Myasthenia Gravis: A Systematic Review

Cited by 98 publications

References 44 publications

Population Incidence of Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis

Population Incidence of Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis

Coherent Somatic Mutation in Autoimmune Disease

Precision medicine in myasthenia graves: begin from the data precision

Contact Info

Product

Resources

About