Frequency of antiparvovírus B19 antibodies in rheumatoid arthritis and systemic lupus erythematosus

Silva, Clemar Pereira da; Rêgo, Jozélia; Barbosa, Vitalina de Souza; Cruz, Vítor Alves; Silva, Nílzio Antônio da

doi:10.1016/j.rbre.2014.02.002

Cited by 2 publications

(6 citation statements)

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“…ELsedig et al 18 reported a significant incidence of anti B19 in Sudanese patients suffering from RA as IgM and IgG were detected in 34.4% and 54.4% of RA patients respectively. Similar results were obtained in Brazil, Silva et al 19 reported positive anti-B19 IgG in 86. 0% of RA patients.…”

Section: Discussionsupporting

confidence: 83%

“…By nested PCR, B19-DNA was detected in 34% and 6.7 % of our RA patients' sera and controls respectively with a statistically significant difference (P =0.05). The same result was published in Latvia in two different studies that were conducted by Kozireva et al 21 and Naciute et al 22 Also, Chen et al 20 mentioned that viral DNA was positive in 30.6% and 9.1% in plasma samples from patients and controls respectively (p = 0.005) and Silva et al 19 detected B19-DNA in 30.6% of plasma samples obtained from RA patients. These findings suggested that B19 may be involved in the development of RA.…”

Section: Discussionsupporting

confidence: 66%

“…In Taiwan, Chen et al 20 found that plasma anti-B19 (IgG and/or IgM) was positive in 93.6% of patients with highly significant differences when compared with controls (p <0.001). Silva et al 19 explained the higher prevalence anti-B19 among RA patients for the existence of a higher susceptibility of RA patients to acquire viral infections due to immunosuppression or by other immunological characteristics in these patients. Also, the probability of B19 acting as a trigger for development of RA cannot be rolled out.…”

Section: Discussionmentioning

confidence: 99%

“…However, some authors used the mechanism of molecular mimicry to demonstrate the role of B19 in RA pathogenesis. Cross reaction may occur between Anti-VP1 IgG and type II collagen, which represents a target antigen for autoantibodies in the RA 19 . Others suggested another scenario in which non-structure protein (NS1) play a serious role as it is a transcriptional activator on the promoters of IL-6 gene leading to up regulation of IL-6 together with persistence of B19 in B cells, T cells, dendritic cells and macrophages, this may alter host cellular immunity.…”

Section: Discussionmentioning

confidence: 99%

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Molecular and Serological Study of Parvovirus B19 Infection among Rheumatoid Arthritis Patients at Menoufia University Hospital

Elkhyat

Saied

Galbat

et al. 2022

Egyptian Journal of Medical Microbiology

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Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. Conflicting reports are available about the association between human parvovirus B19 (B19) infection and RA. Most studies were done in European and Asian countries, but only few studies were performed in Africa. Objectives: This study aimed to investigate the seroprevalence of parvovirus B19 infection in RA patients compared with healthy controls and to search for possible association of B19 viremia with disease activity and severity. Methodology: This case-control study was conducted on 50 RA patients who fulfilled the 2010 American College of Rheumatology/European League against Rheumatism classification criteria for rheumatoid arthritis and 30 matched healthy controls. All participants were examined for parvovirus B19 infection by serological detection of anti-B19 IgM and IgG by ELISA and B19 DNA by nested PCR. Results: Parvovirus B19 DNA was detected in 17 (34%) of patients While controls were (6.7%) with a significant difference (0.005). There was significant difference between patients and controls (P=0.007) regarding IgG anti-B19 antibody but not anti-B19 IgM (P =0.59). There was a significant association between B19 viremia and all activity parameters. B19 positive patients had higher levels of ESR and CRP, higher DAS28 scores and more affected joints than B19 negative patients with statistically significant differences. B19 positive patients had significantly higher levels of RF and anti-CCP. Furthermore, B19 positive patients were more likely to have joint erosion. Conclusion: This study revealed that parvovirus B19 infection may play a role in the aetiopathogenesis of RA.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Molecular and Serological Study of Parvovirus B19 Infection among Rheumatoid Arthritis Patients at Menoufia University Hospital

Elkhyat

Saied

Galbat

et al. 2022

Egyptian Journal of Medical Microbiology

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“…A semelhança entre as características da infecção pelo B19 e o LES tem sugerido um possível papel para esse vírus na patogênese do lúpus, desencadeando a doença ou exarcebando seus sintomas 9,61,62,63,64 66,70 . Entretanto, a variável idade mostrou-se fortemente associada à positividade para IgG anti-B19.…”

Section: Discussionunclassified

Avaliação diagnóstica das infecções por vírus Epstein-Barr, parvovírus B19 e vírus linfotrópico de células T humanas em pacientes portadores de lúpus eritematoso sistêmico em hospital de referência do Estado do Pará, Brasil

Costa¹,

Silva²,

Oliveira³

et al. 2016

Revista Pan-Amazônica de Saúde

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RESUMOO lúpus eritematoso sistêmico (LES) é uma doença autoimune crônica, cujo desenvolvimento pode estar associado à infecção por vírus, como o vírus Epstein-Barr (EBV), parvovírus B19 e vírus linfotrópico de células T humanas (HTLV). Durante o período de junho a setembro de 2014, foi realizado um estudo transversal, incluindo 85 pacientes oriundos do Hospital Jean Bitar, na Cidade de Belém, Estado do Pará, Brasil. Foi realizada a pesquisa de anticorpos específicos contra os agentes virais estudados, assim como pesquisa da presença do genoma para EBV e HTLV. Foram avaliadas também variáveis clínicas e epidemiológicas. A maioria dos pacientes eram mulheres, tinham média de idade de 30 anos e se declararam brancos. Para EBV, detectou-se positividade de 37,6% para IgM, 98,8% para IgG e 2,4% por qPCR, com quantificações de 85.028 e 298 cópias do genoma/mL de plasma. Para B19, a positividade para IgM foi 0% e para IgG 67,1%. Não houve detecção sorológica ou por qPCR de HTLV. Foi verificada relação estatisticamente significante entre a positividade para IgM anti-EBV e pacientes mais jovens. Esse achado pode estar relacionado com a maior eficiência na produção dessa imunoglobulina nas infecções primárias agudas, que ocorrem geralmente em indivíduos infantes ou adultos jovens. Adicionalmente, o resultado de IgG anti-B19 foi associado à idade avançada dos pacientes, provavelmente por um maior tempo de exposição ao vírus aliado à persistência desse marcador após o contato. A presença dos marcadores não esteve associada às variáveis clínicas e epidemiológicas. Entretanto, o percentual de positividade para o marcador de infecção aguda por EBV pode sugerir um envolvimento do vírus com o LES. Palavras-chave: Lúpus Eritematoso Sistêmico; Vírus Epstein-Barr; Parvovírus B19; HTLV. ARTIGO ORIGINAL | ORIGINAL ARTICLE ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease whose development may be associated with viral infections, such as Epstein-Barr virus (EBV), parvovirus B19, and human T-cell lymphotropic virus (HTLV).A cross-sectional study was performed between June and September 2014 involving 85 patients from the Hospital Jean Bitar, located in Belém, Pará State, Brazil. A survey of specific antibodies against the studied viral agents was conducted, in addition to a survey of the EBV and HTLV genomes. Clinical and epidemiologic variables were also evaluated. Most patients were female, approximately 30 years old, and declared themselves as Caucasians. The following positive results were detected for EBV: IgM = 37.6%, IgG = 98.8%, and qPCR = 2.4%, with 85,028 and 298 copies of the genome per milliliter of plasma. Positive results for B19 were: IgM = 0%, IgG = 67.1%. Serological or qPCR detection did not reveal HTLV. A significant statistical correlation was observed between anti-EBV IgM antibodies and younger patients. These findings may be related to the highly efficient production of this immunoglobulin during acute primary infections, which frequently occurs in children and young adults. Furthermore, t...

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Frequency of antiparvovírus B19 antibodies in rheumatoid arthritis and systemic lupus erythematosus

Cited by 2 publications

References 37 publications

Molecular and Serological Study of Parvovirus B19 Infection among Rheumatoid Arthritis Patients at Menoufia University Hospital

Molecular and Serological Study of Parvovirus B19 Infection among Rheumatoid Arthritis Patients at Menoufia University Hospital

Avaliação diagnóstica das infecções por vírus Epstein-Barr, parvovírus B19 e vírus linfotrópico de células T humanas em pacientes portadores de lúpus eritematoso sistêmico em hospital de referência do Estado do Pará, Brasil

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