Frequency of Antibodies to Various Antigenic Determinants in Polytransfused Patients with Homozygous Thalassaemia in Greece

Economidou, J.; Constantoulakis, M.; Augoustaki, Olga; Adinolfí, Matteo

doi:10.1111/j.1423-0410.1971.tb00436.x

Cited by 50 publications

(16 citation statements)

References 14 publications

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“…Possibly liver damage and infections play an important role. Also the continuous antigenic stimulus of blood transfusions, with the production of a variety of antibodies, should be considered (Economidou et al, 1971). Neither is it known why after splenectomy IgA and IgG levels rise and IgM levels fall compared with presplenectomy levels and with non-splenectomised patients nor whether this is related to the increased incidence of infections (Constantoulakis et al, 1973b).…”

Section: Discussionmentioning

confidence: 99%

Serum immunoglobulin concentrations before and after splenectomy in patients with homozygous beta-thalassaemia.

Constantoulakis¹,

Trichopoulos²,

Avgoustaki³

et al. 1978

J Clin Pathol

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SUMMARY Serum IgM, IgA, and IgG concentrations were measured in 19 patients suffering from blood-dependent homozygous 3-thalassaemia. The study was prospective and the same patients served as presplenectomy controls. IgG levels rose rapidly and continuously after splenectomy. IgA levels also rose but not so sharply. IgM fell to low levels within one month after the operation and remained low for about 18 months. A similar pattern was found in the cross-sectional part of the study comprising 39 splenectomised and 51 non-splenectomised patients who were tested once.

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Section: Discussionmentioning

confidence: 99%

Serum immunoglobulin concentrations before and after splenectomy in patients with homozygous beta-thalassaemia.

Constantoulakis¹,

Trichopoulos²,

Avgoustaki³

et al. 1978

J Clin Pathol

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“…, 2000). The incidence of antibody formation was less when transfusion was started in the first year of life (Economidou et al. , 1971).…”

Section: Introductionmentioning

confidence: 99%

RBC alloimmunization in blood transfusion‐dependent β‐thalassemia patients in southern Iran

Karimi

Nikrooz

Kashef

et al. 2006

Int J Lab Hematology

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beta-thalassemia is considered a severe, progressive anemia, which needs regular transfusions for life expectancy. One of the most important complications of regular blood transfusions may be alloimmunization, which increases the need for transfusion. This study was performed to investigate the production of red cell alloantibodies in beta-thalassemia patients in Shiraz, southern Iran. Blood sampling was performed among 711 beta-thalassemia patients in Dastgheib hospital in 2002-2004. Direct and indirect coombs tests were performed to check the auto and alloantibodies and a panel test was conducted to detect the type of alloantibodies. Auto and alloantibodies were observed among 1.7% and 5.3% of patients, respectively. The most common alloantibodies were Anti-kell (50%) > Anti-Rh (D) (15.8%) > Anti-Rh (E) (10.5%). All the patients who had developed alloantibody were in the age group of 6 years or more. So for decreasing the rate of alloantibody synthesis, we should crossmatched the packed cells for minor blood groups especially for kell and Rh(E) in addition to major blood groups from the start of transfusion.

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“…Anti‐HLA class I antibodies causing PTR is a common and serious complication of alloimmunised patients receiving long‐term platelet transfusions (Cid et al ., ). In this study, the rate of alloimmunisation was 114 of 204 (55.88%), which was close to that of many earlier publications (Table ) (Economidou et al ., ; Friedman et al ., ; Kurz et al ., ; Ferreira et al ., ; Al‐Ouda et al, ), including 112 of 114 (98.25%) caused by anti‐HLA class I antibodies. As most of platelet transfusion refractory patients had haematological diseases, we showed that the antibody‐positive rate was significantly different between the haematological disease group and the other disease group.…”

Section: Discussionmentioning

confidence: 99%

Analysis of platelet‐reactive alloantibodies and evaluation of cross‐match‐compatible platelets for the management of patients with transfusion refractoriness

Wang

Xia

Deng

et al. 2017

Transfusion Medicine

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Frequency of Antibodies to Various Antigenic Determinants in Polytransfused Patients with Homozygous Thalassaemia in Greece

Cited by 50 publications

References 14 publications

Serum immunoglobulin concentrations before and after splenectomy in patients with homozygous beta-thalassaemia.

Serum immunoglobulin concentrations before and after splenectomy in patients with homozygous beta-thalassaemia.

RBC alloimmunization in blood transfusion‐dependent β‐thalassemia patients in southern Iran

Analysis of platelet‐reactive alloantibodies and evaluation of cross‐match‐compatible platelets for the management of patients with transfusion refractoriness

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