Frequency of anti-neutrophil cytoplasmic antibodies in patients with systemic lupus erythematosus

Santacruz-Sandoval, Evelyn; Aragón, Cristian C.; Nieto-Aristizábal, Ivana; Ruiz-Ordóñez, Ingrid; Quijano, Jhoan S.; Ramírez-Castillo, Daniela; M, Karen Mondragón; Posso-Osorio, Iván; Barrera, María Claudia; Ríos-Serna, Lady J.; Tobón, Gabriel J.

doi:10.1016/j.rcreu.2021.01.002

Cited by 1 publication

(6 citation statements)

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“…Twenty-two studies were selected for review, including 8651 SLE patients. Eight studies were from China, 2,11–17 two from South Korea, 18,19 and one from Germany 20 Netherlands, 21 Japan, 22 Hungary, 23 Malaysia, 24 USA, 25 UK, 26 Canada, 27 Italy, 28 Bulgaria, 29 and Colombia 3 each and one including individuals from several European countries. 30 The main findings are summarized in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…In studies that examined antilactoferrin, positivity was found and it ranged from 8.3% 11 to 32.2%. 22 Concerning clinical associations, ANCA was associated with disease activity in four studies, 3,15,22,29 while in two studies, it was not. 20,29 Serositis was more prevalent in ANCA-positive individuals in three studies.…”

Section: Literature Reviewmentioning

confidence: 95%

“…In six studies, 2,13,15,16,19,28 the sample was limited to patients with lupus nephritis and one study included only patients with renal biopsies. 26 Among total patients with SLE, the ANCA prevalence by IIF ranged from 13% 21 to 81.1% 3 ; by ELISA it ranged from 0% to 22.2% for MPO; 20,23 ; from 0 to 12.2% for PR-3 20,21,29 and from 10.1 to 32.2 % for lactoferrin. 20,21 ANCA prevalence in studies limited to patients with lupus nephritis ranged from 3.5 % (ELISA) 2 to 42% (ELISA plus IIF).…”

Section: Literature Reviewmentioning

confidence: 98%

“…23,27 The anti-dsDNA was associated with ANCA in four studies, 12,16,23,26 but no association was found in six studies. 3,[20][21][22][23]25…”

Section: Literature Reviewmentioning

confidence: 99%

“…The prevalence of ANCA in SLE varies considerably. It ranges from 3.5% 2 to 81% 3 with a variety of possible associations with clinical and prognostic characteristics. The clinical expression of SLE is strongly influenced by genetic background and varies according to the geographical location of the studied sample.…”

Section: Introductionmentioning

confidence: 99%

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ANCA in patients with systemic lupus erythematosus. A cross sectional study in Brazilian patients and review of literature

Nisihara,

Vithoft,

Alencar

et al. 2024

Lupus

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Background Antineutrophil cytoplasmatic antibodies (ANCA) have been detected in patients with systemic lupus erythematosus (SLE). In this study, we investigated the presence of ANCA in a sample of Brazilian SLE patients and its possible associations with clinical and serological outcomes. Additionally, we reviewed the literature of on ANCA in SLE. Results The presence of ANCA was detected in 130 patients using indirect immunofluorescence (IIF). The test was positive in 29.9% of the cases (17.6% pANCA and 11.5% cANCA). Male sex and peripheral vasculitis were more prevalent in the ANCA-positive sample. cANCA was associated with lupus anticoagulant and pANCA had a positive association with peripheral vasculitis and a negative association with anti- SSB/La antibodies. In the 22 studies included in the literature review, a wide range of ANCA positivity was found (13% to 81.1% by IIF and 0 to 22.2% by ELISA). ANCA was associated with renal damage in the Asian population. Although other associations have been found in isolated studies, they were not consistently reported. Conclusions The ANCA prevalence found in this Brazilian sample was within the range reported in the literature and these autoantibodies were more frequent in males and in patients with vasculitis. The literature showed controversial results on the association between ANCA and SLE disease activity or clinical characteristics.

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