Frequency of Agenesis of the Corpus Callosum in the Developmentally Disabled Population as Determined by Computerized Tomography

Jeret, Joseph S.; Serur, David; Wisniewski, Krystyna E.; Fisch, Clifford

doi:10.1159/000120229

Cited by 172 publications

(122 citation statements)

References 3 publications

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“…Although total absence of this brain structure is rare, occurring at a rate of 0.1% in the typical population and 2% in the developmentally disabled (Jeret et al, 1986), a higher rate of ACC has been reported in individuals with FAS (Riley, et al, 1995;Swayze et al 1997). Also, ACC is commonly accompanied by ventricular abnormalities, as midline structures typically adjoining the corpus callosum are displaced (Johnson et al, 1996).…”

Section: Corpus Callosummentioning

confidence: 99%

Neuroimaging and fetal alcohol spectrum disorders

Spadoni

McGee

Fryer

et al. 2007

Neuroscience & Biobehavioral Reviews

127

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Heavy prenatal alcohol exposure causes permanent structural alterations to the brain and can lead to numerous cognitive and behavioral outcomes. Consistent with many of the neuropsychological and behavioral deficits that have been reported, neuroimaging studies reveal a pattern of structural abnormalities associated with prenatal alcohol exposure. This chapter systematically reviews structural anomalies by brain region, identifying cognitive and behavioral correlates when relevant. The consensus shows that in addition to the overall reduction of brain size, prominent brain shape abnormalities have been observed, with narrowing in the parietal region and reduced brain growth in portions of the frontal lobe. Commensurate with these anomalies, volumetric and tissue density findings cite disproportionate reductions in the parietal lobe, cerebellar vermis, corpus callosum, and the caudate nucleus, suggesting that certain areas of the brain may be especially vulnerable to prenatal alcohol exposure. In sum, neuroimaging techniques have greatly advanced our understanding of brain-behavior relationships in fetal alcohol spectrum disorders (FASD), and hopefully will lead to improved diagnosis and treatment options for those affected by prenatal exposure to alcohol.

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Section: Corpus Callosummentioning

confidence: 99%

Neuroimaging and fetal alcohol spectrum disorders

Spadoni

McGee

Fryer

et al. 2007

Neuroscience & Biobehavioral Reviews

127

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“…The latter occurs in Walker-Warburg syndrome and other types of lissencephaly, in which Probst bundles are generally not seen.The two types of secondary of callosal abnormalities include (1) absence of the corpus callosum associated with major malformations of the embryonic forebrain prior to formation of the anlage of the corpus callosum; and (2) degeneration or atrophy of the corpus callosum, which results in striking thinning that may again be mistaken for true agenesis of the corpus callosum (Dobyns, 1996). Its incidence in the general population is 3-7 per 1000 birth; in children with developmental disabilities is 2-3 per 100 (Grogono, 1968;Jeret et al, 1985;Glass et al, 2008), among patients undergoing cranial magnetic resonance imaging at a tertiary care referral institution was determined to be 0.25% (Hetts et al .,2006). Also, a population-based survey indicates that the combined prevalence of agenesis and hypoplasia of the corpus callosum before age 1 year is only 1.8 per 10,000 live births (Glass et al, 2008).…”

Section: Malformations Of the Corpus Callosummentioning

confidence: 99%

Brain Commissural Anomalies

Yousefi¹

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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“…2 It may be present alone or in combination with other malformations. Since the corpus callosum develops from front to back, the partial dysgenesis usually occurs at middle to posterior part of the corpus callosum.…”

Section: Dysgenesis Of Lhe Corpus Callosummentioning

confidence: 99%

Magnetic Resonance Imaging of Congenital Brain Malformations

Sarwar¹

1987

J Islam Med Assoc

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A bstractBrain malformations constitute an important cause of morbidity and mortality in the pediatric age group. Magnetic resonance imaging (MRI) Central nervous system (CNS) malformations constitute an important part of genetic disorders that now number more than 2,000. They occur in almost one percent of all births and represent at least lOOlo of all systemic malformations. Approximately 7511/o of fetal deaths, 40% of infant deaths and .0511/o of deaths in children under one year of age are caused by CNS malformations. The most severe forms of malformations are incompatible with life and are usually aborted . The ones that are clinically encountered are relatively mild in severity.Magnetic resonance imaging (MRI) has revolutionized the evaluation of neurological diseases and provides exquisite neuroanatomical detail. Magnetic resonance imaging basicaJly comprises placement of the patient in a magnet that results in alignment of the protons in the North to South axis of the magnet. By employing a radiofrequency that varies with str,ength of the magnet the protons are disturbed from their axis for a short moment. As soon as the radiofrequency application is terminated, the protons move back to regain their original position. In the process they emit a radiofrequency thac is picked up by an antenna. This information is then used by

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Frequency of Agenesis of the Corpus Callosum in the Developmentally Disabled Population as Determined by Computerized Tomography

Cited by 172 publications

References 3 publications

Neuroimaging and fetal alcohol spectrum disorders

Neuroimaging and fetal alcohol spectrum disorders

Brain Commissural Anomalies

Magnetic Resonance Imaging of Congenital Brain Malformations

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