Frequency of ABCB1 C3435T and CYP3A5*3 Genetic Polymorphisms in the Lebanese Population

Milane, Aline; Khazen, Georges; Olaywan, Layal; Zarzour, Fatima; Mohty, Razan; Sarkis, Aline; Zalloua, Pierre; Barbari, A

doi:10.6002/ect.2021.0101

Cited by 3 publications

(1 citation statement)

References 27 publications

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“… 17 - 19 Furthermore, in spite of the well-established genetic impact on the pharmacokinetic and pharmacodynamics effects of immunosuppressive drugs, knowledge of genetic variants affecting CyA bioavailability and bioactivity are also very limited as we have recently shown in the Lebanese population. 20 In spite of the limited resources in such a developing country, the availability of TDM is critical and certainly cost effective given its important role as a tool to monitor immunosuppressive therapy in order to ensure optimal therapeutic efficacy while minimizing serious adverse events such as bacterial and viral infections.…”

Section: Discussionmentioning

confidence: 99%

Association Between Blood and Lymphocyte Levels of Cyclosporin A and Infectious Complications in Renal Transplant Patients

et al. 2021

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Objectives This study aims to investigate a potential association between whole blood and lymphocyte Cyclosporin A (CyA) levels and the occurrence and frequency of infectious complications in kidney transplant patients. Methods The study involves 130 kidney transplant recipients who received CyA in addition to Mycophenolate Mofetil and steroids. CyA whole blood trough and maximum level (CyA BL0 and CyA BLm) as well as the corresponding levels in the lymphocytes (CyA L0 and CyA Lm) were measured for 6 months post-transplantation. Results Cytomegalovirus (CMV) as well as urinary tract infections (UTIs) were the most commonly diagnosed with an incidence of 24.6% and 26.2%, respectively. Only CyA L0 showed a significant association with CMV infection occurrence (adjusted OR = 1.051, 95% CI .997–1.025, P-value 0.046). A positive linear correlation was found between CyA BL0, CyA BLm and CyA Lm and the number of CMV episodes per patient. Conclusion We showed an association between the CMV infections occurrence and the trough lymphocyte level of CyA (CyA L0). Both lymphocyte CyA levels also correlated with the frequency of CMV infections. Further studies are needed to establish the optimal range of both CyA blood and lymphocyte levels and decrease the risk of opportunistic infections in high risk patients.

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Section: Discussionmentioning

confidence: 99%