Frequency Doubling Technology Perimetry and Changes in Quality of Life of Glaucoma Patients: A Longitudinal Study

Abe, Ricardo Y.; Gracitelli, Carolina P. B.; Diniz-Filho, Alberto; Zangwill, Linda M.; Weinreb, Robert N.; Medeiros, Felipe A.

doi:10.1016/j.ajo.2015.04.007

Cited by 19 publications

(11 citation statements)

References 39 publications

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“…Therefore, it is not surprising that it will carry a significant risk of disability even for a patient who started out with a normal field in the better eye, but it will be devastating and carry a much higher risk of disability for a subject who already had a significant loss at baseline in the better eye. These results are in agreement with previous studies demonstrating an association between visual field change over time and change in NEI-VFQ 25 scores, 14, 19–21, 27 however, they provide a quantification of risk that can be more easily incorporated in clinical practice.…”

Section: Discussionsupporting

confidence: 92%

Predicting Vision-Related Disability in Glaucoma

et al. 2018

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Section: Discussionsupporting

confidence: 92%

Predicting Vision-Related Disability in Glaucoma

et al. 2018

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“…This is especially valuable because an increasing body of evidence has revealed the importance of the velocity of visual field loss, in addition to the level of loss itself, on functional disability. 24 – 31 …”

Section: Discussionmentioning

confidence: 99%

Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression

Medeiros

2018

Trans. Vis. Sci. Tech.

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PurposeTo compare global trend-based and point-wise event-based analysis for detecting visual field progression in eyes with glaucoma.MethodsThe study included a cohort of 367 glaucoma eyes from 265 participants seen over a mean follow-up period of 10 years to develop a computer simulation model of “real-world” visual field results. Progression was evaluated with point-wise event-based analysis using the Guided Progression Analysis (GPA) and global trend-based analysis using the mean deviation (MD) and visual field index (VFI) measures. The specificities of the methods were matched based on a simulated dataset of stable glaucoma eyes, to allow an adequate comparison of their sensitivities for detecting progression.ResultsThe 5-year cumulative false-positive rate for the GPA alert of “possible progression” and “likely progression” (significant change from baseline at two and three consecutive visits, respectively) were 34.0% and 7.0%, respectively. At matched specificities, 27.7% eyes were detected as having progressed after 5 years using the GPA “likely progression” criterion, while 24.6% and 23.8% were detected as having progressed using the global trend–based analysis with MD and VFI, respectively. There was a moderate level of agreement between the GPA and global trend-based analyses.ConclusionsPointwise event-based and global trend–based methods had similar performances to detect glaucoma progression when rigorously matched for specificity.Translational RelevanceAlthough both point-wise event- and global trend–based analyses perform similarly, they could provide complementary information that could be exploited to improve the overall detection of progression in clinical practice and clinical trials.

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“…23 In fact, in previous studies we demonstrated that faster rates of visual field loss were associated with longitudinal decline in self-reported quality of life. 18–21 Patients with relatively slower visual field progression may have more time to adapt to their limited functional status by developing compensatory strategies that might decrease the impact of the disease and, therefore, would have lower chance of developing or reporting depressive symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, we have shown that the rate of visual field loss was associated with decline in self-reported quality of life as measured by the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). 18–21 The NEI VFQ-25 measures several aspects of quality of life, including the ability to perform everyday tasks such as reading and driving. 22 It is likely that a patient with a fast rate of visual field loss experiences greater difficulty with activities of daily living, potentially leading to depressive symptoms, as compared to a subject whose disease has been progressing slowly.…”

Section: Introductionmentioning

confidence: 99%

Fast Visual Field Progression Is Associated with Depressive Symptoms in Patients with Glaucoma

et al. 2016

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Purpose To evaluate the association between rates of progressive visual field loss and the occurrence of depressive symptoms in patients with glaucoma followed over time. Design Prospective observational cohort study. Participants The study included 204 eyes of 102 patients with glaucomatous visual field defects on standard automated perimetry (SAP). Methods All patients had Geriatric Depression Scale (GDS) questionnaires and visual field tests obtained over a mean follow-up time of 2.2 ± 0.6 years. Change in depressive symptoms was assessed by calculating the difference between GDS scores at the last follow-up visit from those at baseline. Rates of visual field loss were assessed by SAP. An integrated binocular visual field was estimated from the monocular SAP tests and rates of change in mean sensitivity (MS) over time were obtained from linear mixed models. Regression models were used to investigate the association between progressive visual field loss and changes in depressive symptoms, adjusting for potentially confounding clinical and socioeconomic variables. Main Outcome Measures The association between rates of change in binocular SAP MS and change in GDS questionnaire scores. Results There was a significant correlation between change in the GDS scores during follow-up and change in binocular SAP sensitivity. Each 1 dB/year change in binocular SAP MS was associated with a change of 2.0 units in the GDS scores during the follow-up period (P = 0.025). In a multivariable model adjusting for baseline disease severity, change in visual acuity, age, gender, race, Montreal Cognitive Assessment score, education, income, and comorbidity index, each 1 dB/year change in binocular SAP MS was associated with a change of 3.0 units in the GDS score (P = 0.019). Conclusions Faster visual field progression was associated with the occurrence of depressive symptoms in patients with glaucoma.

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Frequency Doubling Technology Perimetry and Changes in Quality of Life of Glaucoma Patients: A Longitudinal Study

Cited by 19 publications

References 39 publications

Predicting Vision-Related Disability in Glaucoma

Predicting Vision-Related Disability in Glaucoma

Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression

Fast Visual Field Progression Is Associated with Depressive Symptoms in Patients with Glaucoma

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