Frequency-domain techniques enhance optical mammography: Initial clinical results

Franceschini, Maria Angela; Moesta, K. T.; Fantini, Sergio; Gaida, G.; Gratton, Enrico; Jess, Helge; Mantulin, William W.; Seeber, M; Schlag, Peter M.; Kaschke, Michael

doi:10.1073/pnas.94.12.6468

Cited by 318 publications

(166 citation statements)

References 17 publications

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“…Intra-and interobserver agreement were good to excellent, indicating a reproducible method. Our results are in agreement with previously published studies using different techniques [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Detection rates ranging from 0.04 to 1.00 were reported, irrespective of lesion classification (benign/malignant).…”

Section: Discussionsupporting

confidence: 83%

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

et al. 2009

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This paper presents an evaluation of a prototype diffuse optical tomography (DOT) system. Seventeen women with 18 breast lesions (10 invasive carcinomas, 2 fibroadenomas, and 6 benign cysts; diameters 13-54 mm) were evaluated with DOT and magnetic resonance imaging (MRI). A substantial fraction of the original 36 recruited patients could not be examined using this prototype due to technical problems. A region of interest (ROI) was drawn at the lesion position as derived from MRI and at the mirror image site in the contralateral healthy breast. ROIs were assessed quantitatively and qualitatively by two observers independently in two separate readings. Intra-and interobserver agreements were calculated using kappa statistics (k) and intraclass correlation coefficients (ICCs). Discriminatory values for presence of malignancy were determined by receiver operating characteristic (ROC) analyses. Intraobserver agreements were excellent (k 0.88 and 0.88; ICC 0.978 and 0.987), interobserver agreements were good to excellent (k 0.77-0.95; ICC 0.96-0.98). Discriminatory values for presence of malignancy were 0.92-0.93 and 0.97-0.99 for quantitative and qualitative ROC analysis, respectively. This DOT system has the potential to discriminate malignant from benign breast tissue in a reproducible qualitative and quantitative manner. Important technical improvements are required before this technique is ready for clinical application.

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Section: Discussionsupporting

confidence: 83%

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

et al. 2009

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“…"Optical mammography" is entering the translational stage of research, with several ongoing clinical trials to assess efficacy. 2 The point measurements reviewed in this paper are aimed at providing more detailed information about the tissue, but for one spot at a time. (The actual volume or depth interrogated depends on the details of the optical geometry and other factors specific to the measurement and tissue type.)…”

Section: Introductionmentioning

confidence: 99%

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Bigio

Bown²

2004

Cancer Biology & Therapy

142

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Various types of optical spectroscopy have been investigated as methods to effect a non-invasive, real-time in-situ assessment of tissue pathology. All of these methods have one basic principle in common: the optical spectrum of a tissue contains information about the biochemical composition and/or the structure of the tissue, and that information conveys diagnostic information. The biochemical information can be obtained by measuring absorption, fluorescence, or Raman scattering signals. Structural and morphological information may be obtained by techniques that assess the elastic-scattering properties of tissue. These basic approaches are useful for the detection of cancer as well as for other diagnostic applications such as hemoglobin saturation, intra-luminal detection of atherosclerosis, and simply the identification of different tissue types during procedures. Optical spectroscopic measurements can also be employed in the management of disease treatment. The site-specific pharmacokinetics of chemotherapy and photodynamic therapy agents can be used to customize dosage to the patient, and diagnostic spectroscopy can be used to monitor response to treatment. In recent years clinical studies have provided indications of potential efficacy, and some of these modalities are now entering a translational research stage, with an eye to approval and commercialization. A benefit of these methods is their inherent low cost and ease of implementation, generally mediated with small portable instruments, not requiring any specialized facilities, and eventually not requiring expert interpretation. This paper reviews briefly the most common methods of diagnostic optical spectroscopy, and reviews in greater depth recent clinical translational research invoking scattering spectroscopy as the enabling technology, which has been the experience of the authors.

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“…As optical diagnostic methods become more clinically applicable, there is a growing need to identify and quantify sources of endogenous contrast in breast (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). This article presents the results of quantitative NIR spectroscopic studies in 28 subjects ranging in age from 18 to 64 years.…”

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confidence: 99%

Sources of Absorption and Scattering Contrast for Near-Infrared Optical Mammography

et al. 2001

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Rationale and Objectives. Near-infrared (NIR) diffuse optical spectroscopy and imaging may enhance existing technologies for breast cancer screening, diagnosis, and treatment. NIR techniques are based on sensitive, quantitative measurements of functional contrast between healthy and diseased tissue. In this study, the authors quantified the origins of this contrast in healthy breasts. Materials and Methods.A seven-wavelength frequency-domain photon migration probe was used to perform noninvasive NIR measurements in the breasts of 28 healthy women, both pre-and postmenopausal, aged 18 -64 years. A diffusive model of light transport quantified oxygenated and deoxygenated hemoglobin, water, and lipid by their absorption signatures. Changes in the measured light-scattering spectra were quantified by means of a "scatter power" parameter.Results. Substantial quantitative differences were observed in both absorption and scattering spectra of breast as a function of subject age. These physiologic changes were consistent with long-term hormone-dependent transformations that occur in breast. Instrument response was not adversely affected by subject age or menopausal status. Conclusion.These measurements provide new insight into endogenous optical absorption and scattering contrast mechanisms and have important implications for the development of optical mammography. NIR spectroscopy yields quantitative functional information that cannot be obtained with other noninvasive radiologic techniques.

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Frequency-domain techniques enhance optical mammography: Initial clinical results

Cited by 318 publications

References 17 publications

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging

Spectrroscopic Sensing of Cancer and Cancer Therapy: Current Status of Translational Research

Sources of Absorption and Scattering Contrast for Near-Infrared Optical Mammography

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