Abstract:Consanguineous marriages possibly contributed to the increase in macular dystrophy and CHED in South India. The degenerative changes seen could possibly be related to late presentation or unknown environmental factors and do not have an effect on the ultimate graft outcome.
“…32,35,36 The prevalence of VKC in approximately one-fifth of cases did not reduce graft survival among eyes with keratoconus. The predominance of trachomatous corneal scarring as an etiology for stromal scarring did not reduce graft survival below rates from series that were predominated by traumatic scars or other types of microbial keratitis, a finding that is attributed to very careful selection of patients without significant eyelid or ocular surface contraindications for surgical intervention.…”
In the Saudi Arabian population, the prognosis for graft survival and improved visual acuity is excellent for eyes with keratoconus and stromal dystrophy, good for stromal scarring, and poor for eyes with corneal edema.
“…32,35,36 The prevalence of VKC in approximately one-fifth of cases did not reduce graft survival among eyes with keratoconus. The predominance of trachomatous corneal scarring as an etiology for stromal scarring did not reduce graft survival below rates from series that were predominated by traumatic scars or other types of microbial keratitis, a finding that is attributed to very careful selection of patients without significant eyelid or ocular surface contraindications for surgical intervention.…”
In the Saudi Arabian population, the prognosis for graft survival and improved visual acuity is excellent for eyes with keratoconus and stromal dystrophy, good for stromal scarring, and poor for eyes with corneal edema.
“…No recurrence was reported in DALK series with a short-term follow-up period. 7,9 In a large study performed by Pandrowala et al, 22 the recurrence rate of corneal dystrophies was 2.8% in 181 eyes after PK over a period of 6 years. In the study of Marcon et al, 23 the recurrence rate was highest in eyes with lattice dystrophy (60%) after PK and there was a clinically significant recurrence after 5 years of follow-up.…”
DALK using the big bubble technique is an effective procedure in the treatment of patients with corneal stromal dystrophies. Recurrence of lattice dystrophy was relatively high.
“…LCD and GCD account for approximately 15% to 25% of all patients with corneal dystrophy requiring corneal grafts in our institution, a tertiary-care referral center in southern India. 17 No genetic studies have been reported so far on lattice and granular dystrophies in Indians. We report the results of our study on 37 unrelated patients (18 with LCD, 19 with GCD).…”
Arg124Cys and Arg555Trp appear to be the predominant mutations causing LCD and GCD, respectively, in the population studied. The novel mutations identified in this study are associated with distinct phenotypes.
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