In wireless communications, bandwidth is a valuable resource that can be smartly shared by multiple users simultaneously utilizing multiplexers. This chapter ofers a short review and brief impression of the working principle and the design methodology of the multiplexers in RF and microwave systems. Predominantly used diferent multiplexer design paterns are discussed here, however the compact manifold multiplexer is discussed in details with an example. It is designed by using advanced design system (ADS) software and implemented utilizing Microstrip technology for its low cost and simplicity.