Frequency-dependent retinal responsiveness to sinusoidal electrical stimulation in achromatopsia

Jung, Ronja; Kempf, Melanie; Pohl, Lisa; Kortüm, Friederike; Reith, Milda; Kelbsch, Carina; Kohl, Susanne; Wilhelm, Helmut; Wilhelm, Barbara; Štingl, Katarína; Stingl, Krunoslav

doi:10.1016/j.exer.2022.109349

Experimental Eye Research

2023

DOI: 10.1016/j.exer.2022.109349

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Frequency-dependent retinal responsiveness to sinusoidal electrical stimulation in achromatopsia

Ronja Jung

Melanie Kempf

Lisa Pohl

et al.

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2024

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Cited by 1 publication

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“… 13 CPC can be complemented by cell-specific transcorneal electrostimulation to investigate the residual neuronal function in retinal degenerations. 14 – 16 …”

mentioning

confidence: 99%

“…13 CPC can be complemented by cell-specific transcorneal electrostimulation to investigate the residual neuronal function in retinal degenerations. [14][15][16] Due to retinotopic and photoreceptor specific stimulation in CPC, the loss of central vision in Stargardt disease can be correlated with reduced cone function in the macu-lar region with preserved yet altered rod function in terms of signal processing. 17 In exudative age-related macular degeneration (AMD), previous findings have shown altered PLR 18 and improvements in response dynamics in multifocal pupillography after the application of Ranibizumab.…”

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confidence: 99%

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Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

Jendritza,

Stingl,

Strasser

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.Investigating influencing factors on the pupillary light response (PLR) as a biomarker for local retinal function by providing epidemiological data of a large normative collective and to establish a normative database for the evaluation of chromatic pupil campimetry (CPC). METHODS.Demographic and ophthalmologic characteristics were captured and PLR parameters of 150 healthy participants (94 women) aged 18 to 79 years (median = 46 years) were measured with L-cone-and rod-favoring CPC protocols. Linear-mixed effects models were performed to determine factors influencing the PLR and optical coherence tomography (OCT) data were correlated with the pupillary function volume. RESULTS.Relative maximal constriction amplitude (relMCA) and latency under L-cone-and rod-favoring stimulation were statistically significantly affected by the stimulus eccentricity (P < 0.0001, respectively). Iris color and gender did not affect relMCA or latency significantly; visual hemifield, season, and daytime showed only minor influence under few stimulus conditions. Age had a statistically significant effect on latency under rodspecific stimulation with a latency prolongation ≥60 years. Under photopic and scotopic conditions, baseline pupil diameter declined significantly with increasing age (P < 0.0001, respectively). Pupillary function volume and OCT data were not correlated relevantly. CONCLUSIONS.Stimulus eccentricity had the most relevant impact on relMCA and latency of the PLR during L-cone-and rod-favoring stimulation. Latency is prolonged ≥60 years under scotopic conditions. Considering the large study collective, a representative normative database for relMCA and latency as valid readout parameters for L-cone-and rodfavoring stimulation could be established. This further validates the usability of the PLR in CPC as a biomarker for local retinal function.

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“… 13 CPC can be complemented by cell-specific transcorneal electrostimulation to investigate the residual neuronal function in retinal degenerations. 14 – 16 …”

mentioning

confidence: 99%

mentioning

confidence: 99%

Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

Jendritza,

Stingl,

Strasser

et al. 2024

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

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Frequency-dependent retinal responsiveness to sinusoidal electrical stimulation in achromatopsia

Cited by 1 publication

References 17 publications

Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

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