Gas
species and concentrations of human-exhaled breath correlate
with health, wherein disease markers contain volatile organic compounds
(VOCs) of concentrations in parts per billion. It is expected that
a gas-sensing strategy possesses a gas specificity and detection limit
in the parts per trillion (ppt) range; however, it is still a challenge.
This investigation has exploited the Schottky junction of gas sensors
for detecting the reactance signal of ppt VOC, aiming for a specific
and rapid detection toward disease marker acetone. In this new sensing
paradigm, formed by the engineered energy band between metal–semiconductor
contact, the Schottky junction is accessed to specific modulation
of different adsorbate dopings and the corresponding reactance signal
is measured. Regarding the detection toward ppt concentration of acetone,
this sensing paradigm possesses rapid (∼100 s) and room-temperature
response, molecular specificity, and 34 ppt of detection limit. The
proposed detection paradigm is demonstrated to show a high feasibility
toward detection of disease marker acetone.