Abstract:The purpose of this study was to characterize the effects of cyclic mechanical loading at different frequencies on the intervertebral disc and vertebral endplates. Static, 0.5 Hz or 5 Hz loading at 5 x BW was applied to the rabbit lumbar spine in vivo 2 hours/day, 5 days/week for up to 30 weeks. Following the loading period, MRI, μCT and histology analyses were performed. Results indicate an increase in subchondral bone density in cyclically loaded animals which was loading ratedependent. There was also a decr… Show more
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