Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy

Jiang, Lin; Ma, Xuejin; Li, Shiguang; Luo, Hong-Jian; Zhang, Guoming; Wang, Yanan; Zhang, Tijiang

doi:10.3389/fneur.2020.00645

Cited by 3 publications

(4 citation statements)

References 50 publications

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“…All these validated that the homotopic connectivity might be one of the basic organizational principles of neural underpinning. Interestingly, in this study, we found remote functional connectivity of the contralateral orbitofrontal sulcus with psychological wellbeing, which was consistent with other studies that also demonstrated significant homotopic connectivity changes in the OFC ( Jiang et al, 2020 ). In summary, the strong connection between homotopic brain regions within the OFC in healthy participants might contribute to the integration of emotional and cognitive information to promote individual wellbeing.…”

Section: Discussionsupporting

confidence: 92%

Well-Being Is Associated With Local to Remote Cortical Connectivity

Jiang

2022

Front. Behav. Neurosci.

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Wellbeing refers to cognitive and emotional appraisal of an individual’s life and social functioning, which is of great significance to the quality of life of an individual and society. Previous studies have revealed the neural basis of wellbeing, which mostly focused on human brain morphology or network-level connectivity. However, local-to-remote cortical connectivity, which plays a crucial role in defining the human brain architecture, has not been investigated in wellbeing. To examine whether wellbeing was associated with local-to-remote cortical connectivity, we acquired resting-state images from 60 healthy participants and employed the Mental Health Continuum Short Form to measure wellbeing, including three dimensions, namely, emotional wellbeing, psychological wellbeing, and social wellbeing. Functional homogeneity (ReHo) and seed-based functional connectivity were used to evaluate local-to-remote cortical connectivity in these participants. For local connectivity, our results showed that ReHo in the right orbitofrontal sulcus was significantly positively correlated with psychological wellbeing but negatively correlated with social wellbeing. For remote connectivity, connectivity within the right orbitofrontal cortex and interhemispheric connectivity of the orbitofrontal sulcus were both positively associated with psychological wellbeing; functional connectivity between the right orbitofrontal sulcus and the left postcentral sulcus was positively associated with social wellbeing. Our results showed that wellbeing was indeed associated with local-to-remote cortical connectivity, and our findings supplied a new perspective of distance-related neural mechanisms of wellbeing.

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Section: Discussionsupporting

confidence: 92%

Well-Being Is Associated With Local to Remote Cortical Connectivity

Jiang

2022

Front. Behav. Neurosci.

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“…The study finally included 61 right‐handed subjects (26 children with IGE and 35 healthy controls [HCs]), some of whom were also included in our previous studies 11,35 . Among the children with IGE, 16 patients were regularly administered antiepileptic drugs in accordance with the ILAE treatment guidelines.…”

Section: Resultsmentioning

confidence: 99%

“…The study finally included 61 right-handed subjects (26 children with IGE and 35 healthy controls [HCs]), some of whom were also included in our previous studies. 11,35 Among the children with IGE, 16 patients were regularly administered antiepileptic drugs in accordance with the ILAE treatment guidelines. Eight participants were using valproate sodium, four a combination of valproate sodium and oxcarbazepine, two valproate sodium and clonazepam, one valproate sodium and levetiracetam, and one oxcarbazepine.…”

Section: Participantsmentioning

confidence: 99%

Altered neurovascular coupling in children with idiopathic generalized epilepsy

Ran

Chen

et al. 2022

CNS Neurosci Ther

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Aims Alterations in neuronal activity and cerebral hemodynamics have been reported in idiopathic generalized epilepsy (IGE) patients, possibly resulting in neurovascular decoupling; however, no neuroimaging evidence confirmed this disruption. This study aimed to investigate the possible presence of neurovascular decoupling and its clinical implications in childhood IGE using resting‐state fMRI and arterial spin labeling imaging. Methods IGE patients and healthy participants underwent resting‐state fMRI and arterial spin labeling imaging to calculate degree centrality (DC) and cerebral blood flow (CBF), respectively. Across‐voxel CBF‐DC correlations were analyzed to evaluate the neurovascular coupling within the whole gray matter, and the regional coupling of brain region was assessed with the CBF/DC ratio. Results The study included 26 children with IGE and 35 sex‐ and age‐matched healthy controls (HCs). Compared with the HCs, the IGE group presented lower across‐voxel CBF‐DC correlations, higher CBF/DC ratio in the right posterior cingulate cortex/precuneus, middle frontal gyrus, and medial frontal gyrus (MFG), and lower ratio in the left inferior frontal gyrus. The increased CBF/DC ratio in the right MFG was correlated with lower performance intelligence quotient scores in the IGE group. Conclusion Children with IGE present altered neurovascular coupling, associated with lower performance intelligence quotient scores. The study shed a new insight into the pathophysiology of epilepsy and provided potential imaging biomarkers of cognitive performances in children with IGE.

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“…Consequently, most brain function studies are conducted in the classical frequency range. However, an increasing number of studies have found that intrinsic activity varies across different frequency bands and exhibits frequency-dependent alterations in various brain disorders, such as major depression ( Wang et al, 2018 ), alcohol dependence ( Guo et al, 2019 ) childhood epilepsy ( Jiang et al, 2020 ), and trigeminal neuralgia ( Ge et al, 2024 ).…”

Section: Discussionmentioning

confidence: 99%

Frequency-dependent alterations in functional connectivity in patients with Alzheimer’s Disease spectrum disorders

Hu,

Wang,

Abdul

et al. 2024

Front. Aging Neurosci.

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BackgroundIn the spectrum of Alzheimer’s Disease (AD) and related disorders, the resting-state functional magnetic resonance imaging (rs-fMRI) signals within the cerebral cortex may exhibit distinct characteristics across various frequency ranges. Nevertheless, this hypothesis has not yet been substantiated within the broader context of whole-brain functional connectivity. This study aims to explore potential modifications in degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) among individuals with amnestic mild cognitive impairment (aMCI) and AD, while assessing whether these alterations differ across distinct frequency bands.MethodsThis investigation encompassed a total of 53 AD patients, 40 aMCI patients, and 40 healthy controls (HCs). DC and VMHC values were computed within three distinct frequency bands: classical (0.01–0.08 Hz), slow-4 (0.027–0.073 Hz), and slow-5 (0.01–0.027 Hz) for the three respective groups. To discern differences among these groups, ANOVA and subsequent post hoc two-sample t-tests were employed. Cognitive function assessment utilized the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA). Pearson correlation analysis was applied to investigate the associations between MMSE and MoCA scores with DC and VMHC.ResultsSignificant variations in degree centrality (DC) were observed among different groups across diverse frequency bands. The most notable differences were identified in the bilateral caudate nucleus (CN), bilateral medial superior frontal gyrus (mSFG), bilateral Lobule VIII of the cerebellar hemisphere (Lobule VIII), left precuneus (PCu), right Lobule VI of the cerebellar hemisphere (Lobule VI), and right Lobule IV and V of the cerebellar hemisphere (Lobule IV, V). Likewise, disparities in voxel-mirrored homotopic connectivity (VMHC) among groups were predominantly localized to the posterior cingulate gyrus (PCG) and Crus II of the cerebellar hemisphere (Crus II). Across the three frequency bands, the brain regions exhibiting significant differences in various parameters were most abundant in the slow-5 frequency band.ConclusionThis study enhances our understanding of the pathological and physiological mechanisms associated with AD continuum. Moreover, it underscores the importance of researchers considering various frequency bands in their investigations of brain function.

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Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy

Cited by 3 publications

References 50 publications

Well-Being Is Associated With Local to Remote Cortical Connectivity

Well-Being Is Associated With Local to Remote Cortical Connectivity

Altered neurovascular coupling in children with idiopathic generalized epilepsy

Frequency-dependent alterations in functional connectivity in patients with Alzheimer’s Disease spectrum disorders

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