Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism

Kimbrell, Tim A.; Little, John T.; Dunn, Robert T.; Frye, Mark A.; Greenberg, Benjamin D.; Wassermann, Eric M.; Repella, Jennifer D.; Danielson, Aimee; Willis, Mark W.; Benson, Brenda E.; Speer, Andrew B.; Osuch, Elizabeth A.; George, Mark S.; Post, Robert M.

doi:10.1016/s0006-3223(99)00195-x

Cited by 294 publications

(140 citation statements)

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“…Initial studies used fluorodeoxyglucose (George et al, 1995;Kimbrell et al, 1999) or oxygen (O15) (Paus et al, 1997;Paus and Wolforth, 1998) positron emission tomography (PET). Our group at the Medical University of South Carolina (MUSC) pioneered and developed a technique for interleaving TMS with blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) Shastri et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Interleaved Transcranial Magnetic Stimulation/Functional MRI Confirms that Lamotrigine Inhibits Cortical Excitability in Healthy Young Men

Tenebäck

Nahas

et al. 2004

Neuropsychopharmacol

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Little is known about how lamotrigine (LTG) works within brain circuits to achieve its clinical effects. We wished to determine whether the new technique of interleaved transcranial magnetic stimulation (TMS)/functional magnetic resonance imaging (fMRI) could be used to assess the effects of LTG on activated motor or prefrontal/limbic circuits. We carried out a randomized, double-blind, crossover trial involving two visits 1 week apart with TMS measures of cortical excitability and blood oxygen level-dependent TMS/fMRI. Subjects received either a single oral dose of 325 mg of LTG or placebo on each visit. In all, 10 subjects provided a complete data set that included interleaved TMS/fMRI measures and resting motor threshold (rMT) determinations under both placebo and LTG conditions. A further two subjects provided only rMT data under the two drug conditions. LTG caused a 14.979.6% (mean7SD) increase in rMT 3 h after the drug, compared with a 0.6710.9% increase 3 h after placebo (t ¼ 3.41, df ¼ 11, po0.01). fMRI scans showed that LTG diffusely inhibited cortical activation induced by TMS applied over the motor cortex. In contrast, when TMS was applied over the prefrontal cortex, LTG increased the TMS-induced activation of limbic regions, notably the orbitofrontal cortex and hippocampus. These results suggest that LTG, at clinically relevant serum concentrations, has a general inhibitory effect on cortical neuronal excitability, but may have a more complex effect on limbic circuits. Furthermore, the interleaved TMS/fMRI technique may be a useful tool for investigating regional brain effects of psychoactive compounds.

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Section: Introductionmentioning

confidence: 99%

Interleaved Transcranial Magnetic Stimulation/Functional MRI Confirms that Lamotrigine Inhibits Cortical Excitability in Healthy Young Men

Tenebäck

Nahas

et al. 2004

Neuropsychopharmacol

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“…In a typical protocol, depressed patients are scanned with single photon emission computed tomography (SPECT) or positron emission tomography (PET) before and after rTMS applied over the left MDLFC (1-20 Hz frequency, 1-10 sessions, MDLFC defined as 5 cm anterior to the hand area of the primary motor cortex, eg Kimbrell et al, 1999;Teneback et al, 1999;Speer et al, 2000;Catafau et al, 2001;Nahas et al, 2001;Conca et al, 2002;Mottaghy et al, 2002;Nadeau et al, 2002;Shajahan et al, 2002). Following a single session of high-frequency rTMS, Shajahan et al (2002) reported that the connectivity between a number of brain circuits implicated in affect was significantly stronger.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Action Underlying the Effect of Repetitive Transcranial Magnetic Stimulation on Mood: Behavioral and Brain Imaging Studies

Barrett

Della‐Maggiore

Chouinard

et al. 2004

Neuropsychopharmacol

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In a set of experiments, we applied 10-Hz repetitive transcranial magnetic stimulation (rTMS) over the left mid-dorsolateral frontal cortex (MDLFC) to investigate rTMS-induced changes in affective state and neural activity in healthy volunteers. In Experiment 1, we combined 10-Hz rTMS with a speech task to examine rTMS-induced changes in paralinguistic aspects of speech production, an affect-relevant behavior strongly linked to the ACC. In Experiment 2, we combined 10-Hz rTMS with positron emission tomography (PET) and used partial least squares (PLS) to identify a pattern of brain regions whose connectivity with the site of stimulation varied as a function of rTMS. The results of Experiment 1 revealed that following stimulation of the left MDLFC, subjects reported having less positive affect and vitality and displayed more monotonous speech. In Experiment 2, results revealed that 10-Hz rTMS influenced the covariation between blood flow at the site of stimulation (ie the left MDLFC) and blood flow in a number of affect-relevant brain regions including the perigenual anterior cingulate gyrus, insula, thalamus, parahippocampal gyrus, and caudate nucleus. Taken together, our results suggest that changes in affect and affect-relevant behaviour following 10-Hz rTMS applied over the left MDLFC may be related to changes in neural activity in brain regions widely implicated in affective states, including a frontocingulate circuit.

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“…In total, we retained 19 RCTs in our meta-analysis [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] , totaling 181 patients with bipolar disorder (type I, N540; type II, N520; unspecified, N5121). The RCTs employed different stimulation targets: the left dorsolateral prefrontal cortex (DLPFC) [1][2][3][4][5][6][9][10][11]13,16,17 , the right DLPFC 8,14,15,18 , or bilateral DLPFC 7,12,17,19 .…”

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confidence: 99%

“…The RCTs employed different stimulation targets: the left dorsolateral prefrontal cortex (DLPFC) [1][2][3][4][5][6][9][10][11]13,16,17 , the right DLPFC 8,14,15,18 , or bilateral DLPFC 7,12,17,19 . The majority of studies delivered high-frequency stimulation (HFS) 1,3-6,9-13,16,18 , while some delivered low-frequency stimulation (LFS) 3 The issue of treatment-emergent affective switches in managing bipolar depression is important and controversial, and extends to neuromodulatory treatments. We observed a very low rate of treatment-emergent affective switches, and we did not observe an increased risk associated with active rTMS (1/ 106, 0.9% vs. 1/75, 1.3%, p50.97).…”

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confidence: 99%

Clinical efficacy and safety of repetitive transcranial magnetic stimulation in acute bipolar depression

et al. 2016

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Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism

Cited by 294 publications

References 50 publications

Interleaved Transcranial Magnetic Stimulation/Functional MRI Confirms that Lamotrigine Inhibits Cortical Excitability in Healthy Young Men

Interleaved Transcranial Magnetic Stimulation/Functional MRI Confirms that Lamotrigine Inhibits Cortical Excitability in Healthy Young Men

Mechanisms of Action Underlying the Effect of Repetitive Transcranial Magnetic Stimulation on Mood: Behavioral and Brain Imaging Studies

Clinical efficacy and safety of repetitive transcranial magnetic stimulation in acute bipolar depression

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