Frequency, clinical and laboratory features of thyroiditis in girls with Turner's syndrome

Radetti, Giorgio; Mazzanti, Laura; Paganini, Chiara; Bernasconi, Sergio; Russo, Giuseppina; Rigon, F.; Cacciari, E

doi:10.1111/j.1651-2227.1995.tb13791.x

Cited by 71 publications

(58 citation statements)

References 28 publications

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“…By comparison, the prevalence of positive thyroid autoantibodies was high in Japanese women with Turner syndrome in this study. In previous reports from european countries, the incidence of thyroiditis in girls with Turner syndrome was between 10% and 24% [4][5][6]. The frequency of thyroid abnormalities increases with age in Turner syndrome as well as in the general population.…”

Section: Resultsmentioning

confidence: 99%

Autoimmune Thyroid Diseases in 65 Japanese Women with Turner Syndrome

et al. 2009

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Abstract. Turner syndrome (TS) is associated with a number of complications including thyroid disease. In this study, the prevalence of thyroid disease was evaluated in Japanese women with TS. The medical charts of 65 TS women (age 30±9 years old, range: 15-61), treated with estrogen replacement therapy or with antiosteoporotic pharmaceuticals at our outpatient clinic, were reviewed. History of thyroid disease, titer of thyroid autoantibodies and thyroid function were recorded. Thyroid autoantibodies were undetectable in 28 of 65 women (43%), and thyroid function was normal in all these women. of the 37 women with thyroid autoantibodies (57%), 3 had Graves' disease and 20 women were hypothyroidism and diagnosed as Hashimoto's thyroiditis. The remaining 14 women with euthyroidism were also considered to be so-called probable cases of Hashimoto's thyroiditis. In 20 women with hypothyroidism, 14 (70%) received replacement therapy with levothyroxine. The replacement with levothyroxine started between age 17 and 60 (median: 31 years old). These data showed that more than half of Japanese women with TS in adulthood had thyroid autoantibodies. In women with TS, monitoring of thyroid hormone is important to detect hypothyroidism earlier and start adequate replacement therapy.

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Section: Resultsmentioning

confidence: 99%

Autoimmune Thyroid Diseases in 65 Japanese Women with Turner Syndrome

et al. 2009

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“…11,12 Short stature is almost universal. 13 Additional features are common [14][15][16][17][18][19][20] and are listed in Table 1. Interestingly, the individual's phenotype appears to be dependent on the exact genotype and even the parental origin of the remaining X chromosome.…”

Section: Systemic Featuresmentioning

confidence: 99%

“…33 It should also be noted that the increased prevalence of type II diabetes mellitus (with attendant ophthalmic complications) in Turner's population requires care in regard to exogenous growth hormone and monitoring of glycaemic tolerance. 18,39 …”

Section: Eyementioning

confidence: 99%

Ophthalmic features of Turner's syndrome

Denniston

Butler

2004

Eye

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Turner's syndrome is one of the most common of all chromosomal abnormalities and is associated with significant ophthalmic morbidity. Turner's 1938 account included two patients with strabismus, and hitherto the condition has generated more interest among orthoptists than ophthalmologists. This systematic review of the literature seeks to redress the balance. Based on the pooled data of 274 patients with Turner's syndrome, it is the most complete evaluation so far of the prevalence and severity of ophthalmic problems in this population. This includes both a systematic review of the ophthalmic literature (via Medline) and the much larger body of work available in the orthoptic literature. Finally, we consider recent progress that enables the ophthalmologist to progress from the simple recognition of a phenotype to the correlation of genotypic variations with embryogenesis and consequent features of that phenotype.

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“…A freqüência de anticorpos antitireóideos é alta, de 22,2% a 30% (4,28,37,38), e a época de detecção é, em média, de 12 a 15,3 anos (37,39).…”

Section: Introductionunclassified

“…Dois estudos incluíram como critério diagnóstico os achados de USG (hipoecogenicidade e/ou heterogeneidade). No primeiro, foi realizada USG apenas nas pacientes com anticorpos positivos, e em 10,2% dos casos os achados foram considerados compatíveis com TH (38). No outro, que considerou somente a hipoecogenicidade como sinal de TH, os resultados diferiram acentuadamente do trabalho anterior, uma vez que esse sinal foi encontrado em praticamente todas as pacientes, independentemente da presença de anticorpos ou de disfunção tireóidea (29).…”

Section: Introductionunclassified

Evidências de doença tireóidea auto-imune crônica subclínica em portadoras da Síndrome de Turner

Medeiros

Lemos-Marini

Filho

et al. 2007

Arq Bras Endocrinol Metab

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RESUMOO seguimento de pacientes com síndrome de Turner (ST) freqüentemente revela alterações transitórias, recorrentes e assintomáticas de TSH e/ou hormônios tireóideos (HT). Neste trabalho foram avaliadas estrutura e função da tireóide em portadoras da ST com história de alterações prévias desses hormônios. A casuísti-ca incluiu 24 pacientes, 17 com menos de 20 anos, avaliadas laboratorialmente pelas concentrações séricas de TSH, T 4 livre, T 3 e anticorpos anti-TPO e anti-Tg, e morfologicamente por ultra-sonografia (USG) e cintilografia com pertecnetato99m Tc. Havia alterações de TSH e/ou HT em 13 casos, e em 23 havia alterações USG compatíveis com doença crônica da tireóide, particularmente tireomegalia (estabelecida de acordo com o volume esperado para a estatura) e heterogeneidade do parênquima. A captação foi normal em 21 casos e a distribuição do radiofármaco, homogênea em 22. As alterações hormonais foram independentes da idade, do tempo de evolução, da presença de anticorpos, do número de anomalias USG e de alterações cintilográficas. Pacientes maiores de 20 anos apresentaram maior freqüência de anticorpos e de hipoecogenicidade do parênquima, e houve correlação positiva entre o volume tireóideo e o tempo de evolução, indicando comprometimento progressivo da glândula. Esses resultados sugerem que as alterações encontradas decorram de doença tireóidea auto-imune crônica. Patients with Turner syndrome (TS) frequently exhibit transient, recurrent and asymptomatic variations of TSH and/or thyroid hormones (TH). This work was carried out to evaluate thyroid function and structure in patients with TS who had had such variations in hormone concentrations. Our sample comprised 24 patients, 17 less than 20-years old. Evaluation included serum levels of TSH, free T 4 , total T 3 , TPO and Tg autoantibodies, thyroid ultrasound (US) and scintigraphy with 99m Tcpertechnetate. Thirteen patients had abnormal TSH and/or TH levels; 23 exhibited US features compatible with chronic thyroid disorder, particularly thyromegaly (established according to volume expected for stature) and heterogeneous echogenicity. Uptake was normal in 21 cases and tracer distribution was homogeneous in 22. The finding of abnormal hormone concentrations was independent of age, length of time since the first similar finding, thyroid autoantibodies, number of abnormalities at US and abnormal scintigraphic findings. Patients aged more than 20 years had higher frequency of thyroid antibodies and heterogeneous echogenicity, and thyroid volume was significantly correlated to length of time since detection of the first hormone variation, indicating progressive thyroid disease. These results suggest that subclinical thyroid dysfunction in TS is due to chronic autoimmune thyroid disease. (Arq Bras Endocrinol Metab 2007;51/3:401-409)

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Frequency, clinical and laboratory features of thyroiditis in girls with Turner's syndrome

Cited by 71 publications

References 28 publications

Autoimmune Thyroid Diseases in 65 Japanese Women with Turner Syndrome

Autoimmune Thyroid Diseases in 65 Japanese Women with Turner Syndrome

Ophthalmic features of Turner's syndrome

Evidências de doença tireóidea auto-imune crônica subclínica em portadoras da Síndrome de Turner

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