Frequency and Specificity of Red Blood Cell Alloimmunization in Chilean Transfused Patients

Caamaño, J.; Musante, Evangelina; Contreras, Margarita L.; Ulloa, Hernán Van der Laat; Reyes, Carolina; Inaipil, Verónica; Saavedra, Nicolás; Guzmán, Neftalí

doi:10.1159/000370136

Cited by 15 publications

(10 citation statements)

References 23 publications

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“…They also found that most alloimmunised patients (53·5%) produced only one type of alloantibody, which corroborates with the results found in our study. Additionally, in a more recent study, the incidence of RBC alloimmunisation in transfused individuals was similar to those found in our study (Caamano et al, ). However, these results differ from those of other studies that identified a higher frequency of patients with more than one type of alloantibody (Blumberg et al, ; Fluit et al, ; Schonewille et al, ).…”

Section: Discussioncontrasting

confidence: 99%

HLA polymorphisms and risk of red blood cell alloimmunisation in polytransfused patients with sickle cell anaemia

Rodrigues

Sell

Guelsin

et al. 2017

Transfusion Medicine

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Section: Discussioncontrasting

confidence: 99%

HLA polymorphisms and risk of red blood cell alloimmunisation in polytransfused patients with sickle cell anaemia

Rodrigues

Sell

Guelsin

et al. 2017

Transfusion Medicine

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“…Some studies reported that alloimmunization is more likely in patients who receive more units of blood[ 9 18 ] while others found no significant association between alloantibodies formation and the number of transfused packed RBCs. [ 19 ] In our study, the association of development of alloimmunization and the number of units transfused were not statistically significant ( P = 0.117).…”

Section: Discussioncontrasting

confidence: 57%

Impact of antigenic exposures and role of molecular blood grouping in enhancing transfusion safety in chronically transfused thalassemics

Makroo

Agrawal

Bhatia

et al. 2016

Asian J Transfus Sci

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Background:Red cell alloimmunization is an acknowledged complication of blood transfusion. Current transfusion practices for thalassemia do not cater to this risk. Serological phenotyping is usually not reliable in these cases unless performed before the first transfusion. Under such circumstances, molecular blood grouping is an effective alternative.Aim:To perform molecular blood group genotyping in chronically transfused thalassemia patients and assess the risk of antigenic exposure and incidence of alloimmunization with current transfusion protocols.Materials and Methods:Molecular blood group genotyping was performed for 47 chronically transfused thalassemia patients. Their 1-year transfusion records were retrieved to assess the antigenic exposure and the frequency thereof.Results:Of 47 patients, 6 were already alloimmunized (3 with anti-E and 3 with anti-K) and were receiving the corresponding antigen negative units. We observed that random selection of ABO and Rh D matched units resulted in 57.7% ±8.26% chance of Rh and Kell phenotype matching also. Forty-four patients had received one or more antigenic exposures at least once. The 6 already alloimmunized patients were further exposed to antigens other than the ones they were immunized to. During the study period, only one patient developed an alloantibody, anti-E with exposure to antigens C (92%) and/or E (32%) at each transfusion.Conclusion:Several factors apart from mere antigen exposure may influence the development of alloimmunization as most of our patients received antigenic exposures but not alloimmunized. Our data provide an impetus for future large-scale studies to understand the development of alloimmunization in such patients.

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“… 20 The specificity of RBC alloantibodies varies according to the study population. In Japan, anti-Rh antigens (E, c) and anti-Lewis (Lea) are the most prevalent 4 ; in India and China, anti-Rh (E, D) and anti-MNS (M) 6 , 22 ; in Korea, anti-Lewis (Lea) 28 ; in Chile, anti-Rh (D, E) and anti-Kell (K) 29 ; and in Iran, anti-Kell (K). 30 …”

Section: Discussionmentioning

confidence: 99%

Red blood cell alloimmunization among hospitalized patients: transfusion reactions and low alloantibody identification rate

Pessoni

Ferreira

Silva

et al. 2018

Hematology, Transfusion and Cell Therapy

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BackgroundUnexpected red blood cell alloantibodies can cause hemolytic transfusion reactions. In this study, the prevalence of alloimmunization, the rate of identification of alloantibodies and the rate of blood transfusion reactions among transfused patients were identified in a clinical emergency hospital in Brazil.MethodsTransfusions and clinical records of patients who had a positive indirect antiglobulin test between January and December 2013 were analyzed.ResultsOf 1169 patients who received blood transfusions, 28 had positive indirect antiglobulin tests, with one patient having two positive tests at different times, resulting in 29 positive tests during the period of this study. Alloantibodies were identified in 58.6% (17/29) of the cases. In 27.5% (8/29), identification was inconclusive and it was not possible to confirm alloimmunization. The rate of red blood cell alloimmunization was 1.71% (21/1169). Of 21 cases of alloimmunization, four (19%) were unidentified due to an unusual agglutination profile. All identified alloantibodies were clinically significant (10/17 anti-Rh, 5/17 anti-Kell and 2/17 anti-MNS). In two patients who had positive indirect antiglobulin tests, one had an unidentified alloantibody, and the other had an inconclusive test and developed a hemolytic transfusion reaction.ConclusionThe prevalence of clinically important red blood cell alloantibodies and hemolytic transfusion reactions among patients with unidentified alloantibodies suggests that specific laboratory techniques should be performed to identify alloantibodies in cases of pan-reactivity or autoantibodies to improve transfusion safety.

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Frequency and Specificity of Red Blood Cell Alloimmunization in Chilean Transfused Patients

Cited by 15 publications

References 23 publications

HLA polymorphisms and risk of red blood cell alloimmunisation in polytransfused patients with sickle cell anaemia

HLA polymorphisms and risk of red blood cell alloimmunisation in polytransfused patients with sickle cell anaemia

Impact of antigenic exposures and role of molecular blood grouping in enhancing transfusion safety in chronically transfused thalassemics

Red blood cell alloimmunization among hospitalized patients: transfusion reactions and low alloantibody identification rate

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