Frequency and risk factors of severe hypoglycaemia in insulin‐treated Type 2 diabetes: a cross‐sectional survey

Akram, Kamran; Pedersen‐Bjergaard, Ulrik; Carstensen, Bendix; Borch‐Johnsen, Knut; Thorsteinsson, Birger

doi:10.1111/j.1464-5491.2006.01880.x

Cited by 118 publications

(102 citation statements)

References 24 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A number of studies describing the frequency of SH have been published [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] . However, most of these studies have been performed with a selected cohort 7,8,[11][12][13][14][15][16][17][18][19][20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Severe hypoglycaemia requiring the assistance of emergency medical services - frequency, causes and symptoms

Krnacova¹,

Kubêna²,

Macek³

et al. 2012

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

Aims.To evaluate the incidence of severe hypoglycaemia (SH) requiring the assistance of Emergency Medical Services (EMS) in the general population of the Hradec Králové region, in a 1 year period; to describe the distribution of these events throughout the day, and to analyse the symptoms and causes. Methods. The outcome data were obtained from special forms which were filled in by EMS medical staff. Incidence of SH was calculated and the distribution of events throughout the day was analysed using contingency tables. The relationship between blood glucose levels and the presence or absence of causes and symptoms of hypoglycaemia was evaluated using a general linear model and the regression tree technique. Results. In all, a total of 338 events of SH were recorded in 262 patients. 150 episodes appeared in type 2 diabetic patients, 83 episodes in type 1 diabetic patients. 258 events were documented in insulin-treated patients. The incidence of SH was 2.4 and 0.4 episodes/100 patients/year for type 1 and type 2 diabetic patients, respectively. A significantly greater number of hypoglycaemic episodes was documented between 2 pm and 6 pm (P<0.001). Insulin therapy and alcohol consumption were the most dangerous causes of SH. Conclusions. Hypoglycaemia requiring the assistance of EMS represents an essential problem, especially in type 1 diabetic patients. The percentage of SH is comparable to other frequent diagnoses requiring the assistance of EMS in the region. This study reflects the behaviour of diabetic patients and highlights information which is important in the prevention of SH.

show abstract

Section: Introductionmentioning

confidence: 99%

“…However, most of these studies have been performed with a selected cohort 7,8,[11][12][13][14][15][16][17][18][19][20][21][22] . The incidence of SH varied from 0.038 to 3.2 episodes of SH per patient per year in patients with DM type 1 (ref.…”

Section: Introductionmentioning

confidence: 99%

Severe hypoglycaemia requiring the assistance of emergency medical services - frequency, causes and symptoms

Krnacova¹,

Kubêna²,

Macek³

et al. 2012

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

show abstract

“…19,20,[25][26][27][28][29][30][31] However, some other studies found that ZIP model was better than ZINB model because of less severity of over-dispersion in those study data. [32][33] In addition, some studies considered ZIP model as a good model for count outcome data, but these studies did not explore the ZINB model and couldn't compare the goodness of fit between ZIP model and ZINB model.…”

Section: Results Of Zinb Modelmentioning

confidence: 70%

Study of Zero-Inflated Regression Models in a Large-Scale Population Survey of Sub-Health Status and Its Influencing Factors

Zhu

Han

2017

Chinese Medical Sciences Journal

View full text Add to dashboard Cite

Objective Sub-health status has progressively gained more attention from both medical professionals and the publics. Treating the number of sub-health symptoms as count data rather than dichotomous data helps to completely and accurately analyze findings in sub-healthy population. This study aims to compare the goodness of fit for count outcome models to identify the optimum model for sub-health study.Methods The sample of the study derived from a large-scale population survey on physiological and psychological constants from 2007 to 2011 in 4 provinces and 2 autonomous regions in China. We constructed four count outcome models using SAS: Poisson model, negative binomial (NB) model, zero-inflated Poisson (ZIP) model and zero-inflated negative binomial (ZINB) model. The number of sub-health symptoms was used as the main outcome measure. The alpha dispersion parameter and O test were used to identify over-dispersed data, and Vuong test was used to evaluate the excessive zero count. The goodness of fit of regression models were determined by predictive probability curves and statistics of likelihood ratio test.Results Of all 78 307 respondents, 38.53% reported no sub-health symptoms. The mean number of sub-health symptoms was 2.98, and the standard deviation was 3.72. The statistic O in over-dispersion test was 720.995 (P<0.001); the estimated alpha was 0.618 (95% CI: 0.600-0.636) comparing ZINB model and ZIP model; Vuong test statistic Z was 45.487. These results indicated over-dispersion of the data and excessive zero counts in this sub-health study. ZINB model had the largest log likelihood (-167 519), the smallest Akaike's Information Criterion coefficient (335 112) and the smallest Bayesian information criterion coefficient (335455), indicating its best goodness of fit. The predictive probabilities for most counts in ZINB model fitted the observed counts best. The logit section of ZINB model analysis showed that age, sex, occupation, smoking, alcohol drinking, ethnicity and obesity were determinants for presence of sub-health symptoms; the binomial negative

show abstract

“…Ча-стота гипогликемий неизбежно увеличивается при боль-шой длительности диабета [38], длительном применении инсулина, а также у пациентов, получающих базис-бо-люсную инсулинотерапию [39].…”

Section: безопасность и переносимостьunclassified

Insulin degludec is a new ultra-long-acting insulin analogue

et al. 2014

View full text Add to dashboard Cite

Сахарный диабетДиагностика, контроль и лечение есмотря на большое количество лекарственных препаратов, одобренных для лечения сахарного диабета (СД), инсулинотерапия по-прежнему остается наиболее эффективным вариантом терапии СД 2 типа (СД2) и единственным патогенетически обосно-ванным и жизненно необходимым методом лечения СД 1 типа (СД1) [1]. Более того, в последние годы показания к инсулинотерапии при СД2 значительно расширились. По данным Британского проспективного исследования UKPDS (United Kingdom Prospective Diabetes Study), еже-годно в назначении инсулина нуждаются 5-10% пациен-тов с впервые диагностированным СД2, а спустя 10 лет большинству пациентов для достижения и поддержания целевых параметров гликемического контроля требуется постоянная инсулинотерапия [2]. Раннее и обоснованное назначение инсулинотерапии является основным факто-ром, способствующим длительному поддержанию целе-вых параметров гликемического контроля, способствует снижению частоты микро-и макрососудистых осложне-ний диабета [3][4][5]

show abstract

Frequency and risk factors of severe hypoglycaemia in insulin‐treated Type 2 diabetes: a cross‐sectional survey

Cited by 118 publications

References 24 publications

Severe hypoglycaemia requiring the assistance of emergency medical services - frequency, causes and symptoms

Severe hypoglycaemia requiring the assistance of emergency medical services - frequency, causes and symptoms

Study of Zero-Inflated Regression Models in a Large-Scale Population Survey of Sub-Health Status and Its Influencing Factors

Insulin degludec is a new ultra-long-acting insulin analogue

Contact Info

Product

Resources

About