Frequency and Predictors of Extra-articular Manifestations in Patients with Rheumatoid Arthritis

Elsherbiny, Dalia A.

doi:10.21608/ejhm.2019.42300

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Rheumatoid arthritis (RA) is one the most common inflammatory disorders of the joints 1–4 . It is a systemic illness that afflicts not only the synovial joints but may also result in extra‐articular manifestations (EAMs) involving the skin, nervous, cardiovascular, pulmonary, gastrointestinal, and renal systems 5,7,8 . About 40% of patients with RA usually have EAMs either at the onset or during the progression of the disease 9,10 .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4] It is a systemic illness that afflicts not only the synovial joints but may also result in extra-articular manifestations (EAMs) involving the skin, nervous, cardiovascular, pulmonary, gastrointestinal, and renal systems. 5,7,8 About 40% of patients with RA usually have EAMs either at the onset or during the progression of the disease. 9,10 The most common EAM of RA is skin (20%), usually presenting as nodules found in extensor surfaces of the upper/ lower extremities, within ears, buttocks, also rarely within the internal organs like heart, lungs, and meninges.…”

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A case report of extra‐articular manifestation of rheumatoid arthritis: Rheumatoid nodules in lungs

Bektyrganova,

Kozhakhmet,

Kim

et al. 2023

Int J of Rheum Dis

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Rheumatoid arthritis is a systemic inflammatory disorder primarily affecting joints but not limited to the joints alone. Extra‐articular manifestations involve skin, ocular, gastrointestinal, pulmonary, cardiac, renal, neurological, and hematological systems. Among them, skin manifestations (20%) are most common, presenting as nodules on the extensor surfaces of the upper and lower extremities. In rare cases these nodules can also be detected within the heart and lungs. Interestingly, rheumatoid nodules are often seen in patients on leflunomide, methotrexate, or tumor necrosis factor‐alpha antagonists. Nevertheless, definitive diagnosis requires a histopathological analysis. In this case report, we presented a 49‐year‐old male patient with a relatively short period of disease activity leading to rheumatoid nodules in the lungs. Considering the ongoing COVID‐19 pandemic and that tuberculosis was still endemic in Kazakhstan, achieving the definite diagnosis was challenging. Initial imaging study revealed bilateral polysegmental pneumonia. The tests for COVID‐19 and pulmonary tuberculosis were negative. A follow‐up chest computed tomography scan had signs of disseminated lung lesions of unknown origin. Lung biopsy showed a morphological picture of productive granulomas characteristic for tuberculosis. However, at the second look, typical scarring granulomas typically seen in rheumatoid nodules were observed.

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A case report of extra‐articular manifestation of rheumatoid arthritis: Rheumatoid nodules in lungs

Bektyrganova,

Kozhakhmet,

Kim

et al. 2023

Int J of Rheum Dis

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Design and Evaluation of Continentalic Acid Encapsulated Transfersomal Gel and Profiling of its Anti-arthritis Activity

Akram,

Mazhar,

Afzal

et al. 2023

AAPS PharmSciTech

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Computer-Aided Diagnosis of Pulmonary Nodules in Rheumatoid Arthritis

Mușetescu

Gherghina

Florescu

et al. 2022

Life

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(1) Background: Rheumatoid arthritis (RA) is considered a systemic inflammatory pathology characterized by symmetric polyarthritis associated with extra-articular manifestations, such as lung disease. The purpose of the present study is to use CAD in the detection of rheumatoid pulmonary nodules. In addition, we aim to identify the characteristics and associations between clinical, laboratory and imaging data in patients with rheumatoid arthritis and lung nodules. (2) Methods: The study included a number of 42 patients diagnosed with rheumatoid arthritis according to the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria, examined from January 2017 to November 2022 in the Departments of Rheumatology and Radiology and Medical Imaging of the University of Medicine and Pharmacy of Craiova. Medical records were reviewed. A retrospective blinded review of CT for biopsy-proven pulmonary nodules in RA using Veolity LungCAD software was performed (MeVis Medical Solutions AG, Bremen, Germany). Imaging was also reviewed by a senior radiologist. (3) Results: The interobserver agreement proved to be moderate (κ = 0.478) for the overall examined cases. CAD interpretation resulted in false positive results in the case of 12 lung nodules, whereas false negative results were reported in the case of 8 lung nodules. The mean time it took for the detection of lung nodules using CAD was 4.2 min per patient, whereas the detection of lung nodules by the radiologist was 8.1 min per patient. This resulted in a faster interpretation of lung CT scans, almost reducing the detection time by half (p < 0.001). (4) Conclusions: The CAD software is useful in identifying lung nodules, in shortening the interpretation time of the CT examination and also in aiding the radiologist in better assessing all the pulmonary lung nodules. However, the CAD software cannot replace the human eye yet due to the relative high rate of false positive and false negative results.

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Frequency and Predictors of Extra-articular Manifestations in Patients with Rheumatoid Arthritis

Cited by 3 publications

References 20 publications

A case report of extra‐articular manifestation of rheumatoid arthritis: Rheumatoid nodules in lungs

A case report of extra‐articular manifestation of rheumatoid arthritis: Rheumatoid nodules in lungs

Design and Evaluation of Continentalic Acid Encapsulated Transfersomal Gel and Profiling of its Anti-arthritis Activity

Computer-Aided Diagnosis of Pulmonary Nodules in Rheumatoid Arthritis

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