Frequency and predictors of acute ischaemic lesions on brain magnetic resonance imaging in young patients with a clinical diagnosis of transient ischaemic attack

Tanislav, Christian; Grittner, Ulrike; Fazekas, Franz; Thijs, Vincent; Tatlısumak, Turgut; Huber, Roman; Sarnowski, Bettina von; Putaala, Jukka; Schmidt, Reinhold; Kropp, Peter; Norrving, Bo; Martus, Peter; Gramsch, Carolin; Rolfs, Arndt; Enzinger, Christian

doi:10.1111/ene.13012

Cited by 13 publications

(10 citation statements)

References 26 publications

(43 reference statements)

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“…The frequency of positive DWI findings varied from 9 to 67% between studies [6]. In young patients (median age 46 (40,51) years) with a clinical TIA 15% demonstrated acute DWI lesions on brain MRI [11]. In our study, the frequency of an acute DWI lesion was 29.5% in TIA.…”

Section: Discussionmentioning

confidence: 48%

“…Previous research found that most of the lesions were located in the cortical or subcortical region [11].…”

Section: Discussionmentioning

confidence: 97%

“…Clinical characteristics associated with DWI lesions after TIA are of great significance for the early diagnosis and urgent intervention of TIA and cerebral infarction [9]. Various studies have reported that the presence of DWI lesions in acute TIA is associated with motor weakness, aphasia, dysarthria, left hemispheric presenting symptoms, National Institutes of Health Stroke Scale (NIHSS) score of ≥10 at admission, time from onset to DWI longer than 24 hours, intracranial large artery atherosclerosis and old brain infarctions on MRI [3,10,11]. In this study, we aimed to further identify characteristics associated with the presence of acute DWI lesions in Chinses TIA patients.…”

Section: Introductionmentioning

confidence: 99%

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Dysphasia and platelet count associated with diffusion-weighted images lesions in patients with a clinical diagnosis of transient ischemic attack

Jia

Song

Yuan

2019

Preprint

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Background Magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) is a mandatory tool in the diagnosis of a transient ischemic attack (TIA). Many patients cannot have an MRI in time. The clinical characteristics associated with DWI positivity after TIA are of great significance for the early diagnosis and urgent intervention of TIA and cerebral infarction. This study was conducted to investigate the clinical characteristics associated with DWI lesions in TIA patients. Methods We retrospectively identified patients who met the criteria of symptom duration <24 hours for a clinical diagnosis of TIA, and then screened out 302 patients underwent DWI within 7 days of admission. The patients were divided into DWI positive and DWI negative group. The clinical characteristics including risk factors, clinical manifestation, the laboratory blood tests, the auxiliary examination and the TIA scores were compared between the two groups. We aimed to identify the clinical characteristics associated with DWI lesions using logistic regression analysis. Receiver operating characteristic (ROC) curves and area under the curve (AUC) were calculated to compare the predictive value of various scores such as ABCD2, ABCD3, ABCD3I, Dawson score and the Diagnosis of TIA (DOT) score for DWI lesions in TIA patients. Results A total of 302 patients (mean age, 62(54,70) years; 67.2 % men) were enrolled in this study. There were 89(29.5%) patients with DWI positivity. Logistic regression analysis showed that the clinical characteristics associated with DWI lesions were dysphasia ([OR] 2.129; 95%[CI] 1.215-3.729) and platelet count ([OR] 0.993; 95%[CI] 0.988-0.999). The AUCs [95%CI] for Dawson score was 0.610[0.543-0.678] and the DOT score was 0.625[0.559-0.691]. Conclusion DWI lesions were detected in 29.5% of patients with classically defined TIA and were associated with dysphasia and platelet count. Dawson score and DOT score seem to have the predictability of DWI lesions in TIA patients.

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Section: Discussionmentioning

confidence: 48%

“…Previous research found that most of the lesions were located in the cortical or subcortical region [11].…”

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Dysphasia and platelet count associated with diffusion-weighted images lesions in patients with a clinical diagnosis of transient ischemic attack

Jia

Song

Yuan

2019

Preprint

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“…Klinický obraz je neobyčejně různorodý a potenciálně život ohrožující. Ischemické mozkové příhody představují nejčastější relevantní klinický projev předpokládané paradoxní embolie a vyskytuje se až u 45 % pacientů s kryptogenní ischemickou cévní mozkovou příhodou [22][23][24].…”

Section: Diskuseunclassified

Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients

et al. 2018

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Úvod: Cílem prospektivní studie bylo stanovení významu echokardiografi e a kardiomarkerů v predikci hospitalizační mortality a rizika mozkových infarktů během 12měsíčního sledování u pacientů s plicní embolií (PE) léčených antikoagulační terapií. Metody: Prospektivně bylo vyšetřeno 88 pacientů s akutní PE (39 mužů, průměrný věk 63 let), kteří byli sledováni po dobu 12 měsíců. Osmasedmdesát pacientů bylo v úvodu vyšetřeno magnetickou rezonancí (MR) mozku a transezofageální echokardiografi í (TEE). Po 12 měsících sledování 58 pacientů podstoupilo kontrolní MR mozku. Hospitalizační mortalita a výskyt ischemických cévních mozkových příhod (CMP)/ischemických lézí mozku (ILM) byly analyzovány na základě výsledku echokardiografi e (přítomnost patentního foramen ovale s průkazem pravolevého zkratového toku-PFO/RLS; poměr rozměru pravé a levé komory [right ventricular to left ventricular diameter ratio, RV/LD]; systolická exkurze trikuspidálního anulu [tricuspid annulus plane systolic excursion, TAPSE; vrcholová systolická rychlost trikuspidálního anulu-S T ; odhad systolického tlaku v plicnici [pulmonary artery systolic pressure, PASP]) a výsledných hodnot kardiomarkerů (N-terminální konec prohormonu natriuretického peptidu B [N-terminal pro-B type natriuretic peptide, NT-proBNP] a srdeční troponin T [cTnT]). Výsledky: Z 88 pacientů s PE byla u 11 (12,5 %) jedinců stanovena vysoce riziková forma PE, u 24 (27,3 %) PE s vyšším středním rizikem, u 19 (21,6 %) PE s nižším středním rizikem a u 34 (38,6 %) pacientů nízkoriziková forma PE. Jedenáct (10,2 %) pacientů zemřelo v průběhu hospitalizace, z toho 6 z 9 (66,6 %) s vysoce rizikovou formou PE a 3 z 24 (12,5 %) s vyšším středním rizikem PE. cTnT (odds ratio [OR] 4

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“…Stroke represents the largest proportion of papers published, including those on pathophysiology , acute stroke management and the outcome of patients who have suffered stroke . Stroke is a worldwide problem, but its prevalence varies and may reflect both the genetic and environmental contributions to stroke, both in turn reflecting the known risk factors for stroke.…”

mentioning

confidence: 99%

Advances and insights into neurological practice 2016−17

Schapira¹

2017

Euro J of Neurology

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Frequency and predictors of acute ischaemic lesions on brain magnetic resonance imaging in young patients with a clinical diagnosis of transient ischaemic attack

Cited by 13 publications

References 26 publications

Dysphasia and platelet count associated with diffusion-weighted images lesions in patients with a clinical diagnosis of transient ischemic attack

Dysphasia and platelet count associated with diffusion-weighted images lesions in patients with a clinical diagnosis of transient ischemic attack

Role of echocardiography and cardiac biomarkers in prediction of in-hospital mortality and long-term risk of brain infarction in pulmonary embolism patients

Advances and insights into neurological practice 2016−17

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