Frequency- and phase-sensitive magnetomotive ultrasound imaging of superparamagnetic iron oxide nanoparticles

Evertsson, Maria; Cinthio, Magnus; Fredriksson, Sarah; Olsson, Fredrik; Persson, Henry; Jansson, Tomas

doi:10.1109/tuffc.2013.2591

Cited by 53 publications

(67 citation statements)

References 21 publications

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“…The color bar was adjusted to accommodate displacements up to 0.8 μm, while pixels showing a larger displacement were set to 0.8 μm (white). As expected and seen previously, higher voltages resulted in larger magnetomotive displacement [4,5].…”

Section: Resultssupporting

confidence: 88%

“…the displacement at the precise frequency and phase (± 0.35 radians) of the NPs, was calculated using our previously developed algorithm [4]. For each animal this was done for all voltages (5-60 V, in steps of 5 V) and for six different cross sections.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously developed a motion artefact robust algorithm which is able to detect this movement [4] and most recently we have proven it to successfully image SPIO-laden sentinel lymph nodes (SLN) in rats in situ [5]. The SLN is the first lymph node which drains a primary tumor region, and it is of special therapeutic interest, particularly in cases of breast cancer and malignant melanoma.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vivo magnetomotive ultrasound imaging of rat lymph nodes - a pilot study

Evertsson

Cinthio

Kjellman³

et al. 2015

2015 IEEE International Ultrasonics Symposium (IUS)

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The drive to gain a better understanding of how diseases arise and how to provide ever-earlier detection are some of the key factors for the development of molecular imaging. Compared to other imaging modalities ultrasound has not received the same attention for molecular imaging mainly due to its limited contrast resolution, together with contrast agents confined to the intravascular space. To overcome these issues, new nano-sized contrast agents and new ultrasound imaging techniques e.g. photo acoustic imaging, have been developed. Another such imaging technique under development is magnetomotive ultrasound imaging (MMUS). We have previously developed a frequency and phase tracking algorithm which is able to detect superparamagnetic iron oxide nanoparticles (SPIO NPs) using MMUS, where our suggested first clinical application is to detect sentinel lymph nodes (SLNs) in breast cancer surgery. Recently we have shown detection of SPIO laden rat SLNs in situ.Here we present the feasibility of in vivo detection of SLNs in rats. The algorithm clearly pinpoints the NP laden SLN, even in presence of significant artefactual tissue movement. The magnetomotive displacement increased when a higher voltage was applied on the coil creating the magnetic field (e.g. 56.6% increasing the voltage from 20V to 50V). An uneven concentration distribution of NPs in the SLN was found. The maximum magnetomotive displacement difference between two different cross sections in one SLN was 9.76 times. The study also showed that for a higher concentration of NPs a lower magnetic coil excitation voltage could be used in order to create a magnetomotive displacement of a certain magnitude. The result from this in vivo study shows that the method has potential for future clinical use.

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Section: Resultssupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vivo magnetomotive ultrasound imaging of rat lymph nodes - a pilot study

Evertsson

Cinthio

Kjellman³

et al. 2015

2015 IEEE International Ultrasonics Symposium (IUS)

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“…Evertsson et al used a high-frequency ultrasound scanner to evaluate the motion of superparamagnetic iron oxide nanoparticles, by developing an algorithm based on quadrature detection and phase gating at the frequency of interest [9], [10]. This algorithm could allow for providing .…”

Section: Introductionmentioning

confidence: 99%

Magnetic-based closed-loop control of paramagnetic microparticles using ultrasound feedback

Khalil

Ferreira

Eleuterio

et al. 2014

2014 IEEE International Conference on Robotics and Automation (ICRA)

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Controlling the motion of microrobots based on feedback provided using an imaging modality is essential to make them clinically viable. In this study, we demonstrate the wireless magnetic-based motion control of paramagnetic microparticles using ultrasound feedback. This control is accomplished by pulling the microparticles using the magnetic field gradients towards the reference position through feedback provided by an ultrasound system. First, position of the microparticles is determined using the ultrasound images. Second, calibration of the ultrasound-based tracking of microparticles is achieved and verified using a calibrated microscopic system. Third, the feedback provided by the ultrasound system is used in the implementation of a proportional-derivative magneticbased control system. This control system allows us to achieve point-to-point control of microparticles with an average position tracking error of 48±59 µm, whereas a control system based on a microscopic system achieves an average position tracking error of 21±26 µm. The positioning accuracy accomplished using our ultrasound magnetic-based control system demonstrates the ability to control microrobotic systems in situations where visual feedback cannot be provided via microscopic systems.

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“…superparamagnetic iron oxide nanoparticles (SPIOs), can be found in the literature [7], [8]. SPIOs have been originally used as MR CAs.…”

Section: Introductionmentioning

confidence: 99%

Magnetic control of self-propelled microjets under ultrasound image guidance

Sanchez

Magdanz

Schmidt

et al. 2014

5th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics

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This paper demonstrates closed-loop control of self-propelled microjets using feedback extracted from B-mode ultrasound images. Previous work on control of self-propelled microrobots has mainly employed video cameras equipped with microscopic lenses in order to obtain the required feedback. Nonetheless, in medical applications such as targeted drug delivery, the use of video cameras might be unsuitable for localizing microrobots that navigate within the human body. This issue is a major obstacle for transferring medical microrobotic technologies into the clinic. On that account, the first reported methods and results on control of self-propelled microjets using ultrasound equipment are provided herein. In order to exploit the microjets' self-propulsion mechanism, their motion is directed towards a predefined target by exerting magnetic torques to steer them. Binary image analysis techniques are used to estimate the microjet's position from the ultrasound images. Two air-cored coils are used to generate the steering torques within a plane. Coil currents are calculated using the estimated position error. Results show that our system employing ultrasound images allows control of microjets at an average velocity of 156±35.1 μm/s and with an average tracking error of 250.7±164.7 μm. As a reference, when microscopic image feedback is used in the setup, an average velocity and tracking error of 207±25.9 μm/s and 183.2±84.31 μm, respectively, are observed.

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Frequency- and phase-sensitive magnetomotive ultrasound imaging of superparamagnetic iron oxide nanoparticles

Cited by 53 publications

References 21 publications

In vivo magnetomotive ultrasound imaging of rat lymph nodes - a pilot study

In vivo magnetomotive ultrasound imaging of rat lymph nodes - a pilot study

Magnetic-based closed-loop control of paramagnetic microparticles using ultrasound feedback

Magnetic control of self-propelled microjets under ultrasound image guidance

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