Frequency and factors associated with sarcopenia prediction in adult and elderly patients hospitalized for COVID-19

Aguiar, Gisele Barbosa de; Dourado, Keila Fernandes; Andrade, Maria Izabel Siqueira de; Júnior, Ivanildo Ribeiro Domingos; Neto, João Araújo Barros; Vasconcelos, Sandra Mary Lima; Petribú, Marina de Moraes Vasconcelos; Santos, Cleusa Lapa; Moura, Mayana Wanessa Santos de; Aguiar, Claudiane Barbosa de; Campos, Maria Isabela Xavier; Santiago, Emerson Rogério Costa; Silva, José Hélio Luna da; Simões, Shirley Kelly dos Santos; Rodrigues, Anna Carolina de Melo; Filho, José Carlos Domingues de França; Souza, Natália Mayara; Santos, Thayná Menezes

doi:10.1016/j.exger.2022.111945

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…Aguiar et al 19 , in a study conducted in a northeastern state with adults and older individuals hospitalized with covid-19, demonstrated a higher probability of sarcopenia in older individuals who were non-exercisers, had hypertension, diabetes, and were admitted to an intensive care unit.…”

Section: Discussionmentioning

confidence: 99%

Association between the risk of sarcopenia and clinical complications of covid-19 in hospitalized older adults: a multicenter cohort study

Souza,

Queiroz,

Silva Júnior

et al. 2023

Rev. bras. geriatr. gerontol.

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Objective To investigate whether the risk of sarcopenia in older adults diagnosed with covid-19 is associated with the need for intensive care, mechanical ventilation, and mortality. Method A multicenter cohort study was conducted, including older adults (≥65 years) with laboratory-confirmed covid-19 diagnosis. Data related to sociodemographic, clinical, and nutritional characteristics were collected. The risk of sarcopenia was assessed using the Sarcopenia Risk Screening questionnaire. Outcome variables included the need for intensive care, mechanical ventilation, and mortality. Logistic regressions were performed to assess the association between clinical outcomes and the risk of sarcopenia, adjusting for the following variables: age, gender, family income, physical activity, hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease, and body mass index. Results The study included 264 older adults with covid-19, with an average age of 71.7 (±8.2) years. One hundred and forty-eight older adults (56.1%) were at risk of sarcopenia. Hypertension, diabetes, and cardiovascular disease were the most common comorbidities identified in older adults, at 75.4%, 45.5%, and 28.4%, respectively. The presence of sarcopenia risk in hospitalized older adults with covid-19 increased the odds of ICU admission by more than 2-fold (OR: 2.71 [1.57; 4.68], p<0.001), nearly 5-fold for mechanical ventilation (OR: 5.19 [2.75; 9.78], p<0.001), and over 3-fold for mortality (OR: 4.05 [2.05; 7.98], p<0.001). Conclusion In hospitalized older adults with covid-19, pre-existing risk of sarcopenia was a predictor of unfavorable clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Association between the risk of sarcopenia and clinical complications of covid-19 in hospitalized older adults: a multicenter cohort study

Souza,

Queiroz,

Silva Júnior

et al. 2023

Rev. bras. geriatr. gerontol.

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“…Aguiar et al 19 , em estudo realizado em um estado do nordeste com adultos e pessoas idosas hospitalizados com covid-19, mostraram uma maior probabilidade de sarcopenia em pessoas idosas, não praticantes de atividade física, hipertensos, diabéticos e internados em unidade de terapia intensiva.…”

Section: Discussionunclassified

Associação entre risco de sarcopenia e complicações clínicas da covid-19 em pessoas idosas hospitalizadas: estudo de coorte multicêntrico

Souza,

Queiroz,

Silva Júnior

et al. 2023

Rev. bras. geriatr. gerontol.

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Resumo Objetivo Verificar se o risco de sarcopenia em pessoas idosas diagnosticadas com covid-19 associa-se com demanda por cuidados intensivos, ventilação mecânica e óbito. Método Estudo multicêntrico do tipo coorte, que incluiu pessoas idosas (≥65 anos) com diagnóstico laboratorial confirmado de covid-19. Foram coletados dados relacionados às características sociodemográficas, clínicas e nutricionais. O risco de sarcopenia foi avaliado pelo questionário Sarcopenia Risk Screening. As variáveis de desfecho foram: necessidade de terapia intensiva, ventilação mecânica e óbito. Foram realizadas regressões logísticas para verificar a associação dos desfechos clínicos e o risco de sarcopenia, com as seguintes variáveis de ajuste: idade, sexo, renda familiar, atividade física, hipertensão, diabetes, doença cardiovascular doença pulmonar obstrutiva crônica e índice de massa corporal. Resultados Foram incluídas no estudo 264 pessoas idosas com covid-19, com média de idade de 71,7 (±8,2) anos. Cento e quarenta e oito pessoas idosas (56,1%) tinham risco de sarcopenia. Hipertensão, diabetes e doença cardiovascular foram as principais comorbidades identificadas nas pessoas idosas, respectivamente, 75,4%, 45,5% e 28,4%. O risco de sarcopenia nas pessoas idosas hospitalizadas com covid-19 aumentou em mais de 2 vezes as chances de internamento na UTI (OR: 2,71 [1,57;4,68], p<0,001), em cerca de 5 vezes as chances de ventilação mecânica (OR: 5,19 [2,75;9,78], p<0,001) e em mais de 3 vezes as chances de óbito (OR: 4,05 [2,05;7,98], p<0,001). Conclusão Em pessoas idosas hospitalizadas com covid-19, a pré-existência do risco de sarcopenia foi preditor de desfechos clínicos desfavoráveis.

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“…It is internationally known that our population is aging [ 9 ]. A specific phenomenon that comes with aging is the loss of muscle mass, muscle strength, and physical performance, known as sarcopenia [ 10 , 11 ], which is exacerbated by a pathological condition (i.e., COVID-19) or by physical inactivity as in the case of hospitalization with MV [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

A pulmonary rehabilitation program is an effective strategy to improve forced vital capacity, muscle strength, and functional exercise capacity similarly in adults and older people with post-severe COVID-19 who required mechanical ventilation

Muñoz-Cofré,

del Valle,

Marzuca-Nassr

et al. 2024

BMC Geriatr

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Background It is internationally known that our population is aging. At the same time, some patients with COVID-19, due to their symptoms, required mechanical ventilation (MV) and subsequent pulmonary rehabilitation (PR). This study aimed to compare the effects of a multimodal PR program “ADULT” versus “OLDER” people with COVID-19 who were on MV. Methods The intervention consisted of an 8-week hybrid PR program (2x week). Forced vital capacity (FVC) was measured at the beginning and end of PR, upper and lower limb strength was obtained through hand grip strength (HGS) and the sit-to-stand test (STST), respectively, and functional exercise capacity was measured with the 6-minute walking test (6MWT). Results The main results were an increase in the FVC in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.27), an increase in HGS in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.52), in the same way, the number of repetitions on the STST increased in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.55). Finally, the distance covered on the 6MWT increased in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.65). Conclusions The PR program is an effective strategy to improve FVC, muscle strength, and functional exercise capacity similarly in adults and older people with post severe COVID-19 who required MV.

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Frequency and factors associated with sarcopenia prediction in adult and elderly patients hospitalized for COVID-19

Cited by 5 publications

References 33 publications

Association between the risk of sarcopenia and clinical complications of covid-19 in hospitalized older adults: a multicenter cohort study

Association between the risk of sarcopenia and clinical complications of covid-19 in hospitalized older adults: a multicenter cohort study

Associação entre risco de sarcopenia e complicações clínicas da covid-19 em pessoas idosas hospitalizadas: estudo de coorte multicêntrico

A pulmonary rehabilitation program is an effective strategy to improve forced vital capacity, muscle strength, and functional exercise capacity similarly in adults and older people with post-severe COVID-19 who required mechanical ventilation

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