Frequency and factors affecting the development of acute kidney injury following open heart surgery

Özçelik, Zerrin; Aşkar, Fatma Zekiye

doi:10.28982/josam.642118

Cited by 2 publications

(4 citation statements)

References 31 publications

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“…Off-pump coronary artery bypass grafting, which eschews CPB, holds promise for minimizing perioperative complications [9,10]. One of the most notable complications that arises post-cardiac surgery is AKI, which has profound implications on patient outcomes and healthcare costs [14][15][16][17]. Given the multi-faceted nature of the pathogenesis of AKI, OPCABG might be a potential mitigating solution given that it can possibly counteract certain instigating factors such as systemic inflammation [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…However, the actual impact of OPCABG on postoperative AKI remains a topic of ongoing debate: while some studies have suggested a reduced risk of AKI with offpump techniques, others have found no significant differences [9][10][11][12][13]. A better understanding of this relationship is crucial given that AKI is associated with prolonged hospitalization stays, increased healthcare costs, and elevated long-term morbidity and mortality rates [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Renal implications of off-pump coronary artery bypass grafting: A retrospective cohort study analyzing postoperative creatinine levels

Darcin,

Karakaya

2023

J Surg Med

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Background/Aim: Coronary artery disease is a significant health concern worldwide. While coronary artery bypass grafting is a gold standard of treatment, acute kidney injury (AKI) is a possible postoperative complication of concern. Off-pump coronary artery bypass grafting (OPCABG) aims to curtail perioperative complications; however, its impact on postoperative AKI is debated. This retrospective study aims to inform patient care by identifying potential effects of OPCABG on AKI utilizing postoperative creatinine alterations. Methods: This retrospective study was conducted at Koç University Hospital in Istanbul, Turkey. We reviewed the records of patients who underwent OPCABG between June 2018 and June 2019. Patients with incomplete records or individuals who had undergone renal replacement therapy prior to surgery were excluded. The primary metric was serum creatinine levels, which were assessed preoperatively and up to 7 days postoperatively. Preoperative creatinine levels were compared with postoperative levels using the Wilcoxon signed-rank test. Acute kidney injury was defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Results: Seventy-two patients satisfied the inclusionary criteria. A significant increase in creatinine was observed on postoperative Day 1 (P<0.001); creatinine levels fell below baseline by postoperative Day 4 and 5. We note that the incidence of AKI was low; there were no instances of Stage 2 or higher AKI during the observation period. Conclusion: Our data suggest that OPCABG may result in a transient increase in creatinine post-surgery. Creatinine levels normalize over time, implicating the renal safety of OPCABG. Despite these promising findings, additional comprehensive studies are essential to validate these observations and assess long-term renal outcomes after OPCABG.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Renal implications of off-pump coronary artery bypass grafting: A retrospective cohort study analyzing postoperative creatinine levels

Darcin,

Karakaya

2023

J Surg Med

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“…Development of kidney failure after coronary artery bypass graft (CABG) surgery is one of the significant causes of morbidity and mortality [1]. Cardiac surgery-associated acute kidney injury (CSA-AKI) affects approximately 30% of the cases who undergo cardiac surgery.…”

Section: Introductionmentioning

confidence: 99%

“…To prevent CSA-AKI formation, studies are carried out on modifiable risk factors. Operation time and cross-clamp duration have special significance [1]. The relationship between an increase in earlyterm CyC levels and AKI development has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

The role of serum cystatin C level in detection of early onset kidney injury after coronary artery bypass surgery

Tercan¹,

Patmano²,

Tanrıverdi³

et al. 2020

Journal of Surgery and Medicine

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ACTRN12619000061134). All procedures in this study involving human participants were performed in accordance with the 1964 Helsinki Declaration and its later amendments. Etik Kurul Onayı: Çalışma protokolü Harran Üniversitesi Etik Kurulu (tarih: 07.06.2018 no: 06), tarafından onaylanmıştır (ACTRN Trial ID: ACTRN12619000061134). İnsan katılımcıların katıldığı çalışmalardaki tüm prosedürler, 1964 Helsinki Deklarasyonu ve daha sonra yapılan değişiklikler uyarınca gerçekleştirilmiştir.

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Frequency and factors affecting the development of acute kidney injury following open heart surgery

Abstract: How to cite/Atıf için: Özçelik Z, Askar FZ. Frequency and factors affecting the development of acute kidney injury following open heart surgery.

Cited by 2 publications

References 31 publications

Renal implications of off-pump coronary artery bypass grafting: A retrospective cohort study analyzing postoperative creatinine levels

Renal implications of off-pump coronary artery bypass grafting: A retrospective cohort study analyzing postoperative creatinine levels

The role of serum cystatin C level in detection of early onset kidney injury after coronary artery bypass surgery

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