Frequency and duration of sensory flicker controls astrocyte and neuron specific transcriptional profiles in 5xFAD mice
Sara Bitarafan,
Alyssa F. Pybus,
Felix G. Rivera Moctezuma
et al.
Abstract:Background: Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease, yet we lack a comprehensive picture of the effects of this stimulation on multiple aspects of brain function. While most prior research has focused on gamma frequency sensory stimulation, we previously showed that exposing mice to visual flickering stimulation increased MAPK and NFκB signaling in the visual cortex in a manner dependent on duration and frequency … Show more
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