Frequency and correlates of anxiety and mood disorders among TB- and HIV-infected Zambians

Heuvel, Leigh van den; Chishinga, Nathaniel; Kinyanda, Eugene; Weiss, Helen A.; Patel, Vikram; Ayles, Helen; Harvey, Justin; Cloete, Karen J.; Seedat, Soraya

doi:10.1080/09540121.2013.793263

Cited by 46 publications

(31 citation statements)

References 34 publications

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“…In agreement with previous studies, those with less education and those who had trouble understanding written medical information were more likely to report moderate/ severe depressive symptoms, 10,28 which may be due to a lack of understanding of the diagnoses, treatment, and prognosis. Furthermore, our findings confirm that both internalized and external stigma, as measured by items related to shame, social isolation, and plans to disclose TB diagnosis, are important correlates of depressive symptoms in TB-HIV patients.…”

Section: Discussionsupporting

confidence: 90%

Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho

Hayes‐Larson

Hirsch‐Moverman

Saito

et al. 2017

int j tuberc lung dis

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SUMMARY SETTING Limited data exist on the prevalence and correlates, including stigma, of mental health conditions, including depressive symptoms and alcohol use, among patients co-infected with tuberculosis (TB) and the human immunodeficiency virus (HIV) in sub-Saharan Africa, despite their negative impact on health outcomes. OBJECTIVE To assess the prevalence and correlates of depressive symptoms and hazardous/harmful alcohol use among TB-HIV patients in the Start TB patients on ART and Retain on Treatment (START) study. DESIGN START, a mixed-methods cluster-randomized trial, evaluated a combination intervention package vs. standard of care (SOC) to improve treatment outcomes in TB-HIV co-infected patients in Lesotho. Moderate/ severe depressive symptoms and hazardous/harmful alcohol use were measured using baseline questionnaire data collected from April 2013 to March 2015. Demographic, psychosocial, and TB- and HIV-related knowledge and attitudes, including stigma, were assessed for association with both conditions using generalized linear mixed models. RESULTS Among 371 participants, 29.8% reported moderate/severe depressive symptoms, and 24.7% reported hazardous/harmful alcohol use; 7% reported both. Depressive symptoms were significantly associated with less education, more difficulty understanding written medical information, non-disclosure of TB, greater TB stigma, and the SOC study arm. Hazardous/harmful alcohol use was significantly associated with male sex, as well as greater TB and external HIV stigma. CONCLUSION Prevalence of depressive symptoms and hazardous/harmful alcohol use were high, suggesting a need for routine screening for, and treatment of, mental health disorders in TB-HIV patients.

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Section: Discussionsupporting

confidence: 90%

Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho

Hayes‐Larson

Hirsch‐Moverman

Saito

et al. 2017

int j tuberc lung dis

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“…We also did not find significant association between HIV co-infection and presence of psychiatric illness. This is consistent with the findings of 29 Deribew A (2010) and 27 van den Heuvel (2013).…”

Section: Discussionsupporting

confidence: 93%

“…Anxiety disorders were the next common morbiditypresent in about 23.5% (n=25) patients. The prevalence of anxiety disorders in our study conforms with the finding by 27 van den Heuvel, 2013, who observed a prevalence of 30.8% for any anxiety disorder. An Indian study published in 2016 reports a prevalence of 39% for anxiety disorders in patients with tuberculosis 5 (Kumar K, 2016).…”

Section: Discussionsupporting

confidence: 92%

Psychiatric Morbidity in People With Tuberculosis: A Cross Sectional Study

P.P¹,

Malaiappan²,

Malaiarasan³

2018

jebmh

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BACKGROUND Tuberculosis ranks alongside Human Immunodeficiency Virus as a leading cause of death worldwide. 1,2 Psychiatric disorders in chronic medical illnesses have been found to be associated with poor compliance in previous studies. Poor compliance in tuberculosis can have drastic consequences including emergence of drug resistance. 1,2,3,4,5 In this study, we have attempted to study the prevalence of psychiatric disorders in tuberculosis at a tertiary care centre in Chennai. The objectives of the study were-1. To assess the prevalence of psychiatric illnesses in people undergoing treatment for tuberculosis. 2. To assess the association between psychiatric comorbidity and different socio-demographic factors (age, gender, education) and tuberculosis disease related factors. 3. To assess the relationship between psychiatric comorbidity and negative behavioural factors like history of defaulting. MATERIALS AND METHODS Ours is a cross sectional study conducted at the Department of Thoracic Medicine in Government Kilpauk Medical College, Chennai. A total of 106 patients were interviewed and examined. RESULTS We observed that 63.12% of the patients had at least one psychiatric illness. About 62.6% had depressive disorder. Anxiety disorders were found in 23.5%. We also found significant relationships between the following: male gender and presence of psychiatric illnesses, joint family and presence of psychiatric illnesses, dyspnoea grade 3 or more and presence of psychiatric illnesses, dyspnoea grade 3 or more and severity of depression. CONCLUSION The high prevalence of psychiatric disorders in people with tuberculosis warrants specific screening and management.

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“…Mental health problems such as anxiety and depression in patients infected with HIV is well documented34. In a study35 that evaluated 649 adult patients with HIV, TB or both, the frequency of any anxiety disorder was 30.8%, and the rates of generalized anxiety disorder were highest for the HIV group. Previous default from TB treatment was also statistically associated with symptoms of anxiety in our study.…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life, Depression and Anxiety in Hospitalized Patients with Tuberculosis

2017

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BackgroundMuch of the attention of tuberculosis (TB) programs is focused on outcomes of microbiological cure and mortality, and health related quality of life (HRQL) is undervalued. Also, TB patients have a significantly higher risk of developing depression and anxiety compared with those in the general population. We intend to evaluate the HRQL and the prevalence of symptoms of depression and anxiety in hospitalized patients with TB.MethodsCross-sectional study in a tertiary care hospital in Brazil. Adult patients with pulmonary TB that were hospitalized during the study period were identified and invited to participate. HRQL was measured using the Medical Outcomes Study Short Form-36 (SF-36) version 2. Hospital Anxiety and Depression Scale (HADS) was used to record symptoms of anxiety and depression.ResultsEighty-six patients were included in the analysis. The mean age of all patients was 44.6±15.4 years, 69.8% were male, and 53.5% were white. Thirty-two patients (37.2%) were human immunodeficiency virus positive. Twenty-seven patients (31.4%) met study criteria for depression (HADS depression score ≥11) and 33 (38.4%) had anxiety (HADS anxiety score ≥11). Scores on all domains of SF-36 were significantly lower than the Brazilian norm scores (p<0.001).ConclusionThe present study shows that TB patients may have a poor HRQL. Additionally, we found a possible high prevalence of depression and anxiety in this population. Health care workers should be aware of these psychological disorders to enable a better management of these patients. The treatment of these comorbidities may be associated with better TB outcomes.

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Frequency and correlates of anxiety and mood disorders among TB- and HIV-infected Zambians

Cited by 46 publications

References 34 publications

Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho

Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho

Psychiatric Morbidity in People With Tuberculosis: A Cross Sectional Study

Health-Related Quality of Life, Depression and Anxiety in Hospitalized Patients with Tuberculosis

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