Frequency and clinical correlates of radiographic patterns of bronchopulmonary dysplasia in very low birth weight infants by term age

Hyödynmaa, E; Korhonen, Päivi; Ahonen, Sirkku; Luukkaala, Tiina; Tammela, Outi

doi:10.1007/s00431-011-1486-6

Cited by 14 publications

(21 citation statements)

References 26 publications

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“…84 Nine studies defined CA using a microbiological definition. 28,29,47,53,58,64,131,135,152 Finally, 16 studies 102,104,105,108,113,120,123,128,129,130,139,141,148,155,160,170 did not define CA and, for the purposes of analysis, were considered to evaluate clinical CA.…”

Section: Resultsmentioning

confidence: 99%

Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

et al. 2019

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Key PointsQuestionIs chorioamnionitis a risk factor for developing bronchopulmonary dysplasia in preterm infants?FindingsThis systematic review, meta-analysis, and metaregression found that chorioamnionitis was associated with an increased risk of bronchopulmonary dysplasia in preterm infants but also found significant differences in baseline characteristics between infants with and infants without chorioamnionitis. A multivariate metaregression model combining the difference in gestational age and the odds of respiratory distress syndrome was associated with 64% of the variance in the association between chorioamnionitis and bronchopulmonary dysplasia.MeaningExposure to chorioamnionitis is associated with a higher risk of developing bronchopulmonary dysplasia in preterm infants, but this association may be modulated by gestational age and risk of respiratory distress syndrome.

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Section: Resultsmentioning

confidence: 99%

Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

et al. 2019

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“…CR has demonstrated its capability to predict the evolution of BPD in preterm infants at high risk. Hyödynmaa et al 97 showed that most (89.5%) of the patients who would develop moderate‐to‐severe BPD at 36 weeks PMA had one of the two radiological patterns of leaky lung syndrome (LLS) with hazy/opaque lungs, or cystic BPD (cBPD) with bubbly lung changes. Oxygen demand at discharge is an independent risk factor for cBPD (odds ratio OR 3) 98 .…”

Section: Chest Radiographymentioning

confidence: 99%

Lung growth and pulmonary function after prematurity and bronchopulmonary dysplasia

Moschino

Bonadies

Baraldi

2021

Pediatric Pulmonology

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Bronchopulmonary dysplasia (BPD) still carries a heavy burden of morbidity and mortality in survivors of extreme prematurity. The disease is characterized by simplification of the alveolar structure, involving a smaller number of enlarged alveoli due to decreased septation and a dysmorphic pulmonary microvessel growth. These changes lead to persistent abnormalities mainly affecting the smaller airways, lung parenchyma, and pulmonary vasculature, which can be assessed with lung function tests and imaging techniques. Several longitudinal lung function studies have demonstrated that most preterm‐born subjects with BPD embark on a low lung function trajectory, never achieving their full airway growth potential. They are consequently at higher risk of developing a chronic obstructive pulmonary disease‐like phenotype later in life. Studies based on computer tomography and magnetic resonance imaging, have also shown that in these patients there is a persistence of lung abnormalities like emphysematous areas, bronchial wall thickening, interstitial opacities, and mosaic lung attenuation also in adult age. This review aims to outline the current knowledge of pulmonary and vascular growth in survivors of BPD and the evidence of their lung function and imaging up to adulthood.

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“…In our study, we focused on the interstitial changes alone in evaluating chest radiographs. The interstitial changes on the day 7 chest radiographs were easily noticeable, and a high degree of agreement between observers was obtained [16]. Furthermore, interstitial changes on chest radiograph are less influenced by inflation status, which will be variable in the preterm infants.…”

Section: Discussionmentioning

confidence: 99%

“…Cystic changes on chest radiograph are also associated with BPD or death [11]. However, we did not evaluate cystic changes in this study because cystic changes on chest radiographs were more difficult to distinguish from other diseases, such as infection, sequelae of pulmonary hemorrhage, and pulmonary interstitial emphysema [16]. In addition, cystic changes on chest radiograph represent chronic pathological changes and appear later [17].…”

Section: Discussionmentioning

confidence: 99%

Interstitial pneumonia pattern on day 7 chest radiograph predicts bronchopulmonary dysplasia in preterm infants

Kim

Yun

et al. 2017

BMC Pediatr

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BackgroundEarly identification of infants at higher risk of developing bronchopulmonary dysplasia (BPD) may enable a targeted approach to reduce BPD. We aimed to evaluate the hypothesis that the interstitial pneumonia pattern on the day 7 chest radiograph predicts BPD or death before 36 weeks postmenstrual age (PMA).MethodsA retrospective cohort study was performed on 336 preterm infants (birth weight < 1500 g and gestational age < 32 postmenstrual weeks) who were admitted to a single tertiary academic center between January 2008 and December 2014. Day 7 chest radiographs were independently reviewed by two pediatric radiologists who were unaware of the clinical information regarding each individual infant.ResultsData from 304 infants who survived more than 7 days after birth were collected. The interstitial pneumonia pattern on the day 7 chest radiograph was independently associated with BPD or death before 36 weeks PMA (odds ratio [OR] 4.0, 95% confidence interval [CI] 1.1–14.4). The interstitial pneumonia pattern on the day 7 chest radiograph predicted BPD or death with a specificity of 98%. Histologic chorioamnionitis was a preceding factor that was independently associated with the interstitial pneumonia pattern on the day 7 chest radiograph (OR 3.7, 95% CI 1.3–10.3).ConclusionsThe interstitial pneumonia pattern on the day 7 chest radiograph has a high specificity for predicting BPD or death and can be utilized to select high-risk preterm infants who will benefit from potentially preventive interventions against BPD.Electronic supplementary materialThe online version of this article (doi:10.1186/s12887-017-0881-1) contains supplementary material, which is available to authorized users.

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Frequency and clinical correlates of radiographic patterns of bronchopulmonary dysplasia in very low birth weight infants by term age

Cited by 14 publications

References 26 publications

Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

Association of Chorioamnionitis With Bronchopulmonary Dysplasia Among Preterm Infants

Lung growth and pulmonary function after prematurity and bronchopulmonary dysplasia

Interstitial pneumonia pattern on day 7 chest radiograph predicts bronchopulmonary dysplasia in preterm infants

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