Frequency and circumstances of falls in people with inclusion body myositis: a questionnaire survey to explore falls management and physiotherapy provision

Hiscock, A.; Dewar, L.; Parton, M.; Machado, Pedro; Hanna, Michael G.; Ramdharry, Gita

doi:10.1016/j.physio.2013.06.002

Cited by 14 publications

(17 citation statements)

References 16 publications

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“…In a claims database, falls would be recorded only if they lead to healthcare resource usage. When surveyed with a questionnaire, >60% of people with sIBM typically report a history of falls, but only a fraction of patients report seeking care for falls or receiving falls management input . Hence, it is likely that the rates of falls were underreported in our population.…”

Section: Discussionmentioning

confidence: 99%

Burden of illness and healthcare resource use in United States patients with sporadic inclusion body myositis

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Burden of illness and healthcare resource use in United States patients with sporadic inclusion body myositis

et al. 2017

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“…IBM typically manifests as slowly progressive quadriceps muscle more than hip flexor weakness leading to falls or difficulty standing and next common is finger flexor weakness leading to loss of dexterity [11] [Figure 1]. Falls were reported by 98% of questionnaire respondents, with 60% (37/62) falling frequently [13]. In most cases weakness is markedly asymmetric by at least one MRC grade and preferentially affects in the hand non-dominant distal phalangeal flexors (Table 1).…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Despite falls being a common occurrence for people with IBM, falls guidelines are not being followed, and referral rates to physiotherapy need to improve. [13] A tailored 12-week home exercise program, five days a week for 12 weeks in combination with stationary biking or walks, was found to be safe in seven patients [75]. There was no strength deterioration, no change in serum CK, and no increase in muscle inflammation on biopsy.…”

Section: Exercisementioning

confidence: 99%

Inclusion Body Myositis

2014

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The idiopathic inflammatory myopathies (IIM) are a heterogenous group of rare disorders that share many similarities. In addition to sporadic inclusion body myositis (IBM), these include dematomyositis (DM), polymyositis (PM), and autoimmune necrotizing myopathy (NM). For discussion of later three disorders, the reader is referred to the IIM review in this issue. IBM is the most common IIM after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase (CK) is up to 15 times elevated in IBM and needle electromyograhy (EMG) mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibers often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology suggesting similarity with PM, it likely that IBM is has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy. We review the evolution of our knowledge in IBM with emphasis on recent developments in the field and discuss ongoing clinical trials.

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“…Recent studies have looked at the frequency and circumstances of falls (Hiscock et al, 2014), and have analysed the abnormal gait patterns in patients with IBM (Bernhardt et al, 2011, Davenport et al, 2015 finding that there is a good correlation between knee extensor strength and functional lower limb measures such as the 2-minute and 6-minute walk tests (Lowes et al, 2012, Alfano et al, 2014. A smaller group of patients present initially because of weakness of the long finger flexor muscles, which is usually more severe in the non-dominant hand, or bulbar weakness, with lower limb weakness occurring at a later stage.…”

Section: Patterns Of Muscle Involvementmentioning

confidence: 99%

Sporadic inclusion body myositis: A review of recent clinical advances and current approaches to diagnosis and treatment

Needham

Mastaglia

2016

Clinical Neurophysiology

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Sporadic inclusion body myositis is the most frequent acquired myopathy of middle and later life and is distinguished from other inflammatory myopathies by its selective pattern of muscle involvement and slowly progressive course, and by the combination of inflammatory and degenerative muscle pathology and multi-protein deposits in muscle tissue. This review summarises the findings of recent studies that provide a more complete picture of the clinical phenotype and natural history of the disease and its global prevalence and genetic predisposition. Current diagnostic criteria, including the role of electrophysiological and muscle imaging studies and the recently identified anti-5'-nucleotidase (anti-cN1A) antibody in diagnosis are also discussed as well as current trends in the treatment of the disease.

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Frequency and circumstances of falls in people with inclusion body myositis: a questionnaire survey to explore falls management and physiotherapy provision

Cited by 14 publications

References 16 publications

Burden of illness and healthcare resource use in United States patients with sporadic inclusion body myositis

Burden of illness and healthcare resource use in United States patients with sporadic inclusion body myositis

Inclusion Body Myositis

Sporadic inclusion body myositis: A review of recent clinical advances and current approaches to diagnosis and treatment

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