Frequency and characterization of potential drug interactions in dentistry—a cross-sectional study

Oliveira, Marcelo Lehnen Rodrigues de; Nery, Gabriela Oltramari; Torresan, Thalía Tessaro; Arcanjo, Rafaela Alves; Ferreira, Maria Beatriz Cardoso; Montagner, Francisco

doi:10.1007/s00784-022-04644-1

Cited by 3 publications

(6 citation statements)

References 27 publications

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“…As a result, a high percentage of interactions were identified, suggesting that dentists have a low awareness of DDI [10]. Similar findings were reported by de Oliveira et al [11] in the South of Brazil. Additionally, 25% of patients who were prescribed psychotropic drugs by dental practitioners in Minas Gerais, Brazil, might have experienced some DDI [12].…”

Section: Introductionsupporting

confidence: 69%

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A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication

Aguilar,

Cruz,

Martins

et al. 2024

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To assess the agreement among three different online drug-drug interaction (DDI) checkers for the detection of psychotropic drug interactions among dental patients in the state of Minas Gerais, Brazil. Material and Methods: Between January and December 2017, a cross-sectional study was conducted in Minas Gerais with data on pharmaceutical claims of psychotropic drugs prescribed by dental practitioners. Data from the Pharmaceutical Management System provided the drug dispensing history of the patients, allowing the identification of those on concomitant medication use. The occurrence of DDI was determined by entering the name of the drugs taken by each patient into Merative Micromedex ® , Medscape ® , and DrugBank. The degree of agreement among the three DDI online checkers was analyzed using the Fleiss' kappa test. Results: Overall, 797 dental patients were found to be taking some psychotropic medication with other drugs simultaneously. The number of patients with DDI varied according to Micromedex ® (n= 366), Medscape ® (n= 473), and DrugBank (n= 736). The agreement between the DDI checkers was poor (Fleiss' kappa: 0.165; p<0.001). Conclusion: The online DDI checkers assessed in this study showed variations in their ability to detect interactions and poor agreement among them.

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Section: Introductionsupporting

confidence: 69%

“…Despite interaction checkers, studies have reported a substantial frequency of DDI in patients under dental care [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication

Aguilar,

Cruz,

Martins

et al. 2024

Pesqui. Bras. Odontopediatria Clín. Integr.

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“…de Oliveira et al (2022) simulated drug interactions between the substances administered during dental care, drugs prescribed after the appointment, and, medication already used by the patients to manage chronic diseases. An amount of 359 interactions were reported, mostly graded as “monitor closely” (de Oliveira et al, 2022). These findings may suggest that dentists' ability to identify interactions is limited, consequently, patients are susceptible to adverse drug events.…”

Section: Discussionmentioning

confidence: 99%

“…The great combination of interacting drugs observed in this study was similar to that found in the south of Brazil. de Oliveira et al (2022) simulated drug interactions between the substances administered during dental care, drugs prescribed after the appointment, and, medication already used by the patients to manage chronic diseases. An amount of 359 interactions were reported, mostly graded as “monitor closely” (de Oliveira et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

High prevalence of potential psychotropic drugs interactions among Brazilian dental patients

et al. 2023

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ObjectiveTo determine the prevalence of potential drug–drug interactions involving psychotropics prescribed by dentists, and dispensed by the public healthcare system, as well as to describe the severity and level of evidence of those interactions in the state of Minas Gerais, Brazil.Materials and MethodsWe conducted data analysis from pharmaceutical claims in which dental patients received systemic psychotropics in 2017. Data from the Pharmaceutical Management System provided the drug dispensing history of the patients, allowing the identification of those on concomitant medication use. The outcome was the occurrence of potential drug–drug interactions, which were detected according to IBM Micromedex®. Independent variables were the patient's sex, age, and the number of drugs used. Descriptive statistics was performed using SPSS v. 26.ResultsOverall, 1480 individuals were prescribed psychotropic drugs. The prevalence of potential drug–drug interactions was 24.8% (n = 366). The total of 648 interactions was observed and, most of which were of major severity (n = 438, 67.6%). Most interactions occurred in female individuals (n = 235; 64.2%), with 46.0 (±17.3) years‐old, concurrently taking 3.7 (±1.9) drugs.ConclusionA substantial proportion of dental patients presented potential drug–drug interactions, mostly of major severity, which might be life‐threatening.

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“…One concerning issue related to drug usage is drug interactions. Oliveira et al, (2023) estimated that there were 359 interactions identified in a single Brazilian oral service, with most of them being classified as "monitor closely". This highlights the limited ability of dentists to recognize inappropriate drug combinations that endanger patients' safety.…”

Section: Health Care Professionalsmentioning

confidence: 99%

Promoting dental patient safety toward judicious medication usage: a review

Cruz,

Reis-Oliveira,

Garcez

et al. 2024

Braz. J. Hea. Rev.

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Objective: This critical review aimed to review strategies for health promotion and patient safety regarding the usage of drugs prescribed by dental practitioners. Methods: Manual searches were conducted on PubMed, Embase, and in the Cochrane database of systematic reviews using the keywords “dentistry”, “medication error”, “drug-related side effects and adverse reactions”, and “patient safety”. Publications by the World Health Organization, and the World Dental Federation were also searched to organize this review. Results: Several approaches have been identified to promote patient safety, including continuum education and training of practitioners, interdisciplinary work with clinical pharmacists, and electronic tools to aid practitioners in prescribing the adequate therapeutic regimen avoiding dosage errors and checking for potential drug interactions. Conclusion: Medication errors are common in dentistry, as such, it is fundamental that health professionals, patients, governments, and communities commit to advancing improvements and medication safety.

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Frequency and characterization of potential drug interactions in dentistry—a cross-sectional study

Cited by 3 publications

References 27 publications

A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication

A Comparative Analysis of Three Online Drug-Drug Interaction Checkers: A Short Communication

High prevalence of potential psychotropic drugs interactions among Brazilian dental patients

Promoting dental patient safety toward judicious medication usage: a review

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