Frequency and characteristics of diabetes in 300 pre-liver transplant patients

Marselli, Lorella; Simone, Paolo De; Morganti, Riccardo; Coletti, L; Carrai, P; Catalano, G; Tincani, Giovanni; Ghinolfi, Davide; Occhipinti, Margherita; Filipponi, Franco; Marchetti, Piero

doi:10.1016/j.numecd.2016.02.015

Cited by 12 publications

(16 citation statements)

References 5 publications

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“…and 88.3% and 59.6% in this study by Grancini et al . In contrast, in the cohort described by Marselli et al., 59% of subjects had NGT, whereas only 41% had abnormal glucose regulation (16% with IFG and/or IGT and 35% with DM).…”

Section: Epidemiologycontrasting

confidence: 69%

“…; and 36.8% and 47.2% in this study by Grancini et al . At variance with these results, Marselli et al . reported that, of 208 consecutive cirrhotic patients with normal FPG or IFG, only 7.2% had IGT and 6.3% had DM.…”

Section: Epidemiologycontrasting

confidence: 56%

“…reported that, out of 36 cirrhotic subjects with FPG values in the DM range, 25 (69.4%) had a history of T2DM preceding cirrhosis onset, whereas only 11 (30.6%) met the criterion for hepatogenous diabetes. Moreover, of the 92 cirrhotic patients with DM identified by Marselli et al., 78 (84.8%) had known DM, whereas only 14 (15.2%) were diagnosed by FPG measurement at the time of this study. In contrast, patients with normal FPG (and HbA 1c ) levels and abnormal response to an OGTT likely represent those with hepatogenous diabetes.…”

Section: Epidemiologymentioning

confidence: 57%

“…showed a DM incidence of 35.3% after a 4‐year follow‐up in patients with deteriorating liver function vs 21.2% in the whole cohort. More recently, we reported that DM was present in 20.5% of Child‐Pugh Class A, 56.1% of Child‐Pugh Class B, and 61.2% of Child‐Pugh Class C patients, whereas Marselli et al . did not find significant differences in the prevalence of DM or pre‐DM across Child‐Pugh classes.…”

Section: Epidemiologymentioning

confidence: 63%

“…of 34.4%. In addition, three studies in cirrhotic patients on the waiting list for OLT (including two surveys from our group) reported prevalence values of 41.7%, 27.2%, and 30.7%, respectively, for overt DM, and 16.6%, 3.4%, and 10.3%, respectively, for IFG.…”

Section: Epidemiologymentioning

confidence: 80%

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Hepatogenous diabetes: Is it time to separate it from type 2 diabetes?

Orsi

Grancini

Menini

et al. 2016

Liver International

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By definition, hepatogenous diabetes is directly caused by loss of liver function, implying that it develops after cirrhosis onset. Therefore, it should be distinguished from type 2 diabetes developing before cirrhosis onset, in which specific causes of liver disease play a major role, in addition to traditional risk factors. Currently, although hepatogenous diabetes shows distinct pathophysiological and clinical features, it is not considered as an autonomous entity. Recent evidence suggests that the failing liver exerts an independent "toxic" effect on pancreatic islets resulting in β-cell dysfunction. Moreover, patients with hepatogenous diabetes usually present with normal fasting glucose and haemoglobin A levels and abnormal response to an oral glucose tolerance test, which is therefore required for diagnosis. This article discusses the need to separate hepatogenous diabetes from type 2 diabetes occurring in subjects with chronic liver disease and to identify individuals suffering from this condition for prognostic and therapeutic purposes.

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Section: Epidemiologycontrasting

confidence: 69%

Section: Epidemiologycontrasting

confidence: 56%

Section: Epidemiologymentioning

confidence: 57%

Section: Epidemiologymentioning

confidence: 63%