Frequency and antimicrobial susceptibility of Shigella species isolated in Children Medical Center Hospital, Tehran, Iran, 2001-2006

Abstract

We declare no confl ict of interest. ABSTRACTAppropriate antimicrobial treatment of shigellosis depends on identifying its changing resistance pattern over time. We evaluated 15,255 stool culture submitted from July 2001 to June 2006 to the Laboratory of Children Medical Center Hospital. Specimen culture, bacterial identifi cation, and disk diffusion susceptibility testing were performed according to National Committee for Clinical Laboratory Standards guidelines. From 15,255 stool samples, 682 (4.5%) were positive for Shigella species. The most common species of Shigella were S. fl exneri (48%) and S. sonnei (45%); other results were S. dysenteriae (5%) and S. boydii (2%). The rate of Sensitivity to ceftriaxone (95%), ceftizoxime (94%), and nalidixic acid (84%) were among our isolates. Resistance to co-trimoxazole and ampicillin was 87% and 86%, respectively. S. fl exneri was more multiresistant than other species (47.9%). Our isolates are overall most sensitive to ceftriaxone, ceftazidime, and nalidixic acid (> 84%). They were most resistant to co-trimoxazole and ampicillin (> 86%). Because resistance varies according to specifi c location, continuous local monitoring of resistance patterns is necessary for the appropriate selection of empirical antimicrobial therapy.

<p>First investigation of the presence of <em>SPATE</em> genes in <em>Shigella</em> species isolated from children with diarrhea infection in Ahvaz, southwest Iran</p>

“…in their study was higher than our study (5.1% vs 2.27%) that may reflect the increasing hygiene levels in our region than that reported by Jomezadeh et al Nevertheless, the frequency rate of Shigella spp. in our study was higher than those reported in other reports,19,20 but was comparable to a previous study in Iran 17…”

“…The local epidemiology of Shigella spp. is changing over time 17. In our study, the prevalence rate of Shigella spp.…”

Genotypes and antimicrobial profiles of Shigella sonnei isolates from diarrheal patients circulating in Beijing between 2002 and 2007

“…Identifying and monitoring the local resistance patterns of S. sonnei can provide effective empiric treatment regimens. The resistance rates and single-and multidrug resistance of S. sonnei isolates in Beijing were higher than those reported in other developed and developing countries (Ozmert et al, 2011;Pourakbari et al, 2010;Talukder et al, 2006;Wong et al, 2010;Wu et al, 2009). Our study results revealed that drug resistance occurred in all antibiotics tested with S. sonnei.…”

Molecular analysis of integrons and antimicrobial resistance profile in Shigella spp. isolated from acute pediatric diarrhea patients

“…The results showed that the highest and lowest resistance to ampicillin and gentamicin/ciprofloxacin in S. flexneri were 85.7% (n=6/7) and 14.3% (n=1/7), respectively. Pourakbari et al reported that S. flexneri was more multiresistant than other species [ 14 ]. Results by Zhu et al [ 15 ] showed that resistance of S. sonnei to ampicillin and ciprofloxacin varied and was relatively infrequent, while antimicrobial resistance was common in S. flexneri .…”