Frequency Analysis of Medicinal Prescripts at Pharmacotherapy of Bronchial Asthma in Children

Abstract

Today, bronchial asthma is the most widespread childhood chronic respiratory disease in the world. To make managerial decisions in the health care system of Ukraine and to identify priority areas for the response to this disease, it is necessary to carry out a quantitative analysis of the appointment letters and the proportion of patients who received specific drugs for determining the main areas of therapy. Aim. Carrying out of frequency analysis of medical prescriptions at pharmacotherapy of bronchial asthma in children. Materials and methods. 574 medical cards of an indoor patient with the main diagnosis of "Bronchial asthma", received at the Kyiv City Children's Clinical Hospital №2. A retrospective frequency analysis of the prescribing of drugs for archival data of appointment letters was conducted. Results. The conducted analysis of patients by age and sex allowed to establish the correspondence of the obtained results with the results of previous scientific studies on gender differences in the prevalence of bronchial asthma in children. In 45.3 % of the children, the length of stay was 2-10 days, and in 37.3 % – 11–20 days, indicating a sufficiently long period of inpatient treatment. According to the letters of appointment in the medical records of the inpatient patient, the physicians carried out 1983 appointments, of which 1867 were medicated (94.2 %), and 116 were non-medicated methods (5.8 %). The medical appointments of doctors included 1763 medicines. Of these, 94.4 % are medicines belonging to 11 groups according to ATC classification, 1.5 % – solutions for washing, irrigation, treatment, 0.3 % - dietary supplements, 0.1 % – homeopathic preparations, 3.7 % – other. The data that was obtained when calculating the intensity of the target varies in the range of 0.0006 to 0.07. The highest rates had only 2 drugs – Ventolin nebuli and Pulmicort, which were available in 22.3 % and 23.0 % of the patient's medical cards respectively, that is, every fifth patient. It was found that the ratio of drugs of domestic and foreign manufacture is 34.2 % (20 pharmaceutical companies) and 65.8 % (25 producing countries), respectively. Conclusions. The received data of the conducted analysis of prescriptions of medicinal products allow establishing a significant nomenclature of medical appointments for children with bronchial asthma. The promising direction for domestic pharmaceutical companies in the production of drugs for the treatment of the examined nosology was revealed. At the same time, the frequency analysis of the nomenclature of drugs can be used in the selection of drugs for reimbursement programs and medical insurance after further pharmacoeconomic studies.