“…Further-more, a novel apo E5 derived from E3 by a Glu~Lys substitution at position 13 [E5(Gluls~Lys)] and another novel apo E5 derived from E4 by a Pro--,Arg substitution at position 84 [E5(Proa4~Arg, CySll~--,Arg)] were discovered in two FrenchCanadian subjects (Mailly et al, 1991) and in a subject of European descent (Wardell et al, 1991), respectively; On the other hand, Apo E7 is derived from E3 by a Glu~Lys substitution at positions 244 and 245 [E7(Gluz44,245---,Lys)] (Maeda et al, 1989b;Tajima et al, 1989). Thus far, apo E7 has been detected only among Japanese (Yamamura et al, 1984a, b;Tsuchiya et al, 1985). As for apo E5 and E7, there are no reports regarding their frequencies and relations with plasma lipid levels in general populations.…”