Frequencies at three polymorphic sites of interleukin-10 gene promoter in Brazilian renal recipients

Plothow, Andrea; Benvenutti, Ricardo; Contieri, F.; Bicalho, Maria Gabriela Parenti

doi:10.1016/j.transproceed.2003.10.013

Cited by 10 publications

(2 citation statements)

References 14 publications

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“…Ethnic differences in the haplotype and genotype frequencies within the IL-10 promoter have been reported previously (8,18,25). The genotype frequencies of GG, GA, and AA observed in the Argentinean population were quite similar to the frequencies found in the Brazilian Caucasian population (23). However, as depicted in Table 2, these frequencies differed from those previously reported for other populations.…”

Section: Resultssupporting

confidence: 71%

Gender Susceptibility to Chronic Hepatitis C Virus Infection Associated with Interleukin 10 Promoter Polymorphism

Paladino

Fainboim

Theiler

et al. 2006

J Virol

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Elevated levels of interleukin 10 (IL-10) were previously described for chronically hepatitis C virus (HCV)-infected patients. We determined by a sequence-specific oligonucleotide probing technique the IL-10 promoter genotypes in 286 Argentinean HCV patients grouped according to disease outcome. The GG genotype (position ؊1082) is known to be associated with high IL-10 production, GA is considered an intermediate producer, and AA is associated with low IL-10 production. We found an increase in frequency of the GG genotype in female patients who do not eliminate the virus (RNA ؉ ). In these patients, the GG frequency was 0.19, versus 0.10 in controls (P ‫؍‬ 0.03). This association became more significant in those RNA ؉ female patients with elevated hepatic transaminases (GG frequency of 0.25; P ‫؍‬ 0.0013). Additionally, this genotype frequency was higher in noncirrhotic female patients than in controls (GG frequency for noncirrhotic female patients was 0.31; P ‫؍‬ 0.009). In RNA ؊ patients, the GA frequency was elevated compared with that in controls (GA frequency of 0.76 in RNA ؊ patients versus 0.48 in controls; P ‫؍‬ 0.01), that in all HCV patients (GA frequency of 0.43; P ‫؍‬ 0.001), and that in RNA ؉ patients (GA frequency of 0.40; P ‫؍‬ 0.0005). We conclude that a gender effect is observed with women carrying the GG high IL-10 producer genotype. The higher levels of IL-10 present in those individuals are associated with a higher risk of an inefficient clearance of the HCV and the development of a chronic HCV infection together with a lower risk of progression to cirrhosis in female patients.

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Section: Resultssupporting

confidence: 71%

Gender Susceptibility to Chronic Hepatitis C Virus Infection Associated with Interleukin 10 Promoter Polymorphism

Paladino

Fainboim

Theiler

et al. 2006

J Virol

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“…These genotypes are solely responsible for phenotype, independent of nucleotide variation at positions -819 and -592. Therefore, ATA/ATA, ACC/ATA, ATA/ACA, ACA/ACC and ACC/ACC were classified as low IL-10 production phenotypes; GCC/ACC, GCC/ATA, ATA/GTC, ACC/GCA, ACA/GCC and GTA/ACC were classified as intermediate IL-10 production phenotypes; and GCA/GCC, GTA/GTA, GTA/GCC and GCC/GCC were classified as high IL-10 production phenotypes (40). Low IL-10 production causes an excess of inflammatory cytokines in the periodontal lesions in the chronic form of this disease.…”

Section: Discussionmentioning

confidence: 99%

Effect of ancestry on i interleukin-10 i haplotypes in chronic periodontitis

et al. 2017

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Chronic periodontitis is caused by an inflammatory reaction of the periodontal tissues and alveolar bone. This inflammation is caused by periodontopathic bacteria located in the subgingival biofilm, resulting in inflammatory reactions that may lead to loss of attachment. This tissue destruction is a consequence of host immune and inflammatory responses to specific periodontal pathogens and their metabolic products. Cytokines modulate the immune response, altering its efficiency in the competition against pathogens and increasing periodontal susceptibility. This study investigated genetic polymorphisms in Interleukin 10 (A-1082G, C-819T and C-592A) in 205 individuals from an admixed Brazilian population. A significantly increased risk of developing chronic periodontitis was observed in individuals with low IL-10 production and Amerindian ancestry. These results suggest that the polymorphisms A-1082G, C-819T, and C-592A, which are associated with ancestry, are involved in the susceptibility to the development of chronic periodontitis in an admixed northern Brazilian population.

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Correlation between polymorphisms at interleukin‐6 but not at interleukin‐10 promoter and the risk of human T lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis in Brazilian individuals

Gadelha¹,

Alcântara²,

Costa³

et al. 2008

Journal of Medical Virology

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HTLV-1 is the etiologic agent of ATL and HAM/TSP. The majority of HTLV-1-infected individuals remain asymptomatic, indicating that the infection alone is not sufficient to cause the diseases. It has been reported that cytokine gene polymorphisms, including polymorphisms at IL-6 and IL-10 gene, might be important. We analyzed SNP in the promoter region of the IL-6: -174, -572, -597, and -634 positions, and IL-10: -592 position to evaluate the role of these polymorphisms in the HAM/TSP pathogenesis in 133 HTLV-1 infected individuals and in 100 healthy individuals from Salvador, Bahia, Brazil. The -634C allele frequencies were higher among HAM/TSP patients (21.2%) than among oligosymptomatic (6.5%; P = 0.038) and asymptomatic (9.5%; P = 0.025) subjects. Similarly, the -174G allele frequencies were higher in HAM/TSP patients than in oligosymptomatic patients (P = 0.02). Moreover, the -634GC/-174GG genotype combination was identified at a higher frequency (38.5%) in the HAM/TSP patients than in subjects with other clinical status (8.7%; P = 0.016 for oligosymptomatic and 15.5%, P = 0.012 for asymptomatic patients). However, the multivariate logistic regression including the genotypes of the three studied loci showed that only -634 C IL-6 carriers remain as significant and independent TSP/HAM predictor (odds ratio [OR] = 5.31; 95% [CI] = 1.60-17.56; P = 0.006). We suggest that -634 G C in IL-6 could contribute to HAM/TSP development and that identification of the collective influence of several cytokine polymorphisms, their prevalence, and their interaction could help to better understand this disease.

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Frequencies at three polymorphic sites of interleukin-10 gene promoter in Brazilian renal recipients

Cited by 10 publications

References 14 publications

Gender Susceptibility to Chronic Hepatitis C Virus Infection Associated with Interleukin 10 Promoter Polymorphism

Gender Susceptibility to Chronic Hepatitis C Virus Infection Associated with Interleukin 10 Promoter Polymorphism

Effect of ancestry on i interleukin-10 i haplotypes in chronic periodontitis

Correlation between polymorphisms at interleukin‐6 but not at interleukin‐10 promoter and the risk of human T lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis in Brazilian individuals

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