2011
DOI: 10.1590/s0103-507x2011000400013
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Frequência de insuficiência adrenal em crianças com sepse

Abstract: Objective: To determine the frequency of adrenal insufficiency in children diagnosed with sepsis that were staying in pediatric intensive care units and to establish the association between adrenal function and the use of vasoactive drugs, mechanical ventilation time and mortality.Methods: A cohort-designed study was conducted to assess the incidence of adrenal insufficiency in children aged 29 days to 12 years who were diagnosed with sepsis using the adrenocorticotropic hormone (ACTH) stimulation test.Results… Show more

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Cited by 3 publications
(3 citation statements)
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“…This also agrees with Arnildo et al . (2011), who described a state of adrenal exhaustion in chronic critical illness due to catecholamine receptor desensitization or down regulation and/or chronic secretion of cytokines and other substances that suppress the HPA axis.…”
Section: Discussionsupporting
confidence: 94%
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“…This also agrees with Arnildo et al . (2011), who described a state of adrenal exhaustion in chronic critical illness due to catecholamine receptor desensitization or down regulation and/or chronic secretion of cytokines and other substances that suppress the HPA axis.…”
Section: Discussionsupporting
confidence: 94%
“…Next, the entire axis is exhausted and peripheral cortisol resistance leads to the development of adrenal insufficiency. This also agrees with [14], who described a state of adrenal exhaustion in chronic critical illness due to catecholamine receptor desensitization or down regulation and/or chronic secretion of cytokines and other substances that suppress the HPA axis.…”
Section: Discussion Culture Proved Sepsissupporting
confidence: 92%
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