Fréquence des gammapathies monoclonales chez les donneurs de sang

Incidence of Paraproteinaemia in Blood Donors

“…The data presented by Fine et al [4][5][6] from differ ent Blood Transfusion Centres in Franceand particularly the findings in people from the St-Nazaire area [6] -suggest that the incidence of paraproteinaemia could also be somehow related to the geographical origin of the population studied.…”

Incidence of gammopathies in long‐term plasmapheresis donors at Canadian Blood Services

“…Tichy and coworkers examined serum from 1683 plasma donors (aged 18‐60 years) from 1999 to 2003 and found Mc immunoglobulins in 10 (0.6%). Fine and coworkers found an incidence of Mc gammopathies of 0.14% in 36,015 blood donors, of which 86% were classified as asymptomatic and 14% as malignant. Fine and coworkers detected 20 cases of Mc gammopathies of 13,400 healthy adult blood donors (0.15%) and 26 cases of 13,914 blood donors (0.19%) .…”

“…In agreement with other reports, we found an increased incidence of gammopathies with increasing age. 7,11,14,[27][28][29][30][31] While there is no evidence that continued donation of plasma increases the potential risk of developing a Mc gammopathy in donors or in patients receiving plasma transfusions from such donors, 7,9,11,12 the permanent deferral of plasma donors with Mc gammopathies is nonetheless done as a precautionary measure.…”

“…[1][2][3][4][5][6] Only a limited number of studies have documented the number of monoclonal (Mc) gammopathies in plasmapheresis donors 7,8 or whole blood donors. [9][10][11][12] In those studies, the occurrence of Mc gammopathies ranged from 0.14% to 1.18% for plasma donors 7,8 and 0.14% to 1.3% for blood donors [9][10][11][12] with the occurrence increasing with donor age. While donor sex and/or age were documented in some of those studies, 7,8,11,12 the effect of donation history was not assessed to determine which additional ABBREVIATIONS: CBS 5 Canadian Blood Services; FT In light of a large database of collection and demographic information now available for review, we decided to examine the effects of donor age and sex, donation period, plasma donation frequency per year, and total number of plasma donations on the occurrence of Mc gammopathies or OGGAs.…”

“…Only a limited number of studies have documented the number of monoclonal (Mc) gammopathies in plasmapheresis donors or whole blood donors . In those studies, the occurrence of Mc gammopathies ranged from 0.14% to 1.18% for plasma donors and 0.14% to 1.3% for blood donors with the occurrence increasing with donor age. While donor sex and/or age were documented in some of those studies, the effect of donation history was not assessed to determine which additional factors, if any, were associated with the rate of Mc gammopathies or other gamma globulin abnormalities (OGGAs) observed over an extended period of collections.…”